Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias.

BackgroundSotalol is a commonly used antiarrhythmic drug that may alter ventricular function.ObjectiveTo determine the effect of sotalol on echocardiographic indices of ventricular systolic function in dogs with ventricular arrhythmias.AnimalsThirty-five client-owned dogs with ventricular arrhythmias.MethodsDogs with ventricular arrhythmias (n = 27) had an echocardiogram and 5-minute ECG performed at baseline and 2-4 hours post-sotalol (2-2.5 mg/kg PO once). Eight additional dogs underwent the same protocol but did not receive sotalol (within-day variability controls). Left ventricular (LV) internal dimension at end-systole normalized to bodyweight (LVIDs_N), LV ejection fraction (LV EF), LV shortening area, LV fractional shortening, tricuspid annular plane systolic excursion (TAPSE), and right ventricular systolic myocardial velocity were evaluated as indices of systolic function.ResultsAll indices except TAPSE had mild decreases in systolic function post-sotalol (all P ≤ .0007) compared with baseline but only the percent change in LVIDs_N and LV EF were significantly (P ≤ .0079) different from the percent change of the same indices in control dogs. Sinus heart rate, ventricular premature complexes/5-minutes, and arrhythmia grade also were decreased post-sotalol (all P ≤ .01) compared with baseline when assessed by a 5-minutes ECG. No dog experienced an adverse event post-sotalol, including dogs with systolic dysfunction or atrial enlargement.Conclusions and clinical importanceA single dose of sotalol may cause a mild decrease in LV systolic function in dogs with ventricular arrhythmias. Sotalol appears to be well tolerated, even in dogs with atrial enlargement or systolic dysfunction

Upscaling of the dynamics of dislocation walls

We perform the discrete-to-continuum limit passage for a microscopic model describing the time evolution of dislocations in a one dimensional setting. This answers the related open question raised by Geers et al. in [GPPS13]. The proof of the upscaling procedure (i.e. the discrete-to-continuum passage) relies on the gradient flow structure of both the discrete and continuous energies of dislocations set in a suitable evolutionary variational inequality framework. Moreover, the convexity and $\Gamma$-convergence of the respective energies are properties of paramount importance for our arguments

Regularity of the minimiser of one-dimensional interaction energies

We consider both the minimisation of a class of nonlocal interaction energies over non-negative measures with unit mass and a class of singular integral equations of the first kind of Fredholm type. Our setting covers applications to dislocation pile-ups, contact problems, fracture mechanics and random matrix theory. Our main result shows that both the minimisation problems and the related singular integral equations have the same unique solution, which provides new regularity results on the minimiser of the energy and new positivity results on the solutions to singular integral equations.Comment: 46 page

Use of Maternal Health Care in Tajikstan: A Bargaining Framework

Post-socialist economic declines have included declines in women's use of maternal health care. This paper examines the use of maternal health care in Tajikistan, where such declines have occurred. The findings support previous evidence that women's use of services depends on women's education, household income, and proximity of services. Previous models have not specified who makes the care decision. Using education as a proxy for preferences, the findings show that women share decisionmaking with their spouse and the eldest female in the household. However, the data provides limited evidence that traditional proxies for bargaining power affect outcomes. The authors conclude that measures of bargaining power require tailoring to local conditions. Surveys evaluating the value of women's assets and their services in the home, as well as questions about decision-making, will allow researchers to more effectively measure bargaining power across contexts. The paper concludes with policy recommendations.

Upscaling of dislocation walls in finite domains

We wish to understand the macroscopic plastic behaviour of metals by upscaling the micro-mechanics of dislocations. We consider a highly simplified dislocation network, which allows our microscopic model to be a one dimensional particle system, in which the interactions between the particles (dislocation walls) are singular and non-local. As a first step towards treating realistic geometries, we focus on finite-size effects rather than considering an infinite domain as typically discussed in the literature. We derive effective equations for the dislocation density by means of \Gamma-convergence on the space of probability measures. Our analysis yields a classification of macroscopic models, in which the size of the domain plays a key role

Estimating gender differences in access to jobs: females trapped at the bottom of the ladder

In this paper, we propose a job assignment model allowing for a gender difference in access to jobs. Males and females compete for the same job positions. They are primarily interested in the best-paid jobs. A structural relationship of the model can be used to empirically recover the probability ratio of females and males getting a given job position. As this ratio is allowed to vary with the rank of jobs in the wage distribution of positions, barriers in females' access to high-paid jobs can be detected and quantiffed. We estimate the gender relative probability of getting any given job position for full-time executives aged 40-45 in the private sector. This is done using an exhaustive French administrative dataset on wage bills. Our results show that the access to any job position is lower for females than for males. Also, females' access decreases with the rank of job positions in the wage distribution, which is consistent with females being faced with more barriers to high-paid jobs than to low-paid jobs. At the bottom of the wage distribution, the probability of females getting a job is 12% lower than the probability of males. The difference in probability is far larger at the top of the wage distribution and climbs to 50%.gender ; discrimination ; wages ; quantiles ; job assignment model ; glass ceiling

Dynamics of screw dislocations: a generalised minimising-movements scheme approach

The gradient flow structure of the model introduced in [CG99] for the dynamics of screw dislocations is investigated by means of a generalised minimising-movements scheme approach. The assumption of a finite number of available glide directions, together with the "maximal dissipation criterion" that governs the equations of motion, results into solving a differential inclusion rather than an ODE. This paper addresses how the model in [CG99] is connected to a time-discrete evolution scheme which explicitly confines dislocations to move each time step along a single glide direction. It is proved that the time-continuous model in [CG99] is the limit of these time-discrete minimising-movement schemes when the time step converges to 0. The study presented here is a first step towards a generalisation of the setting in [AGS08, Chap. 2 and 3] that allows for dissipations which cannot be described by a metric.Comment: 17 pages, 2 figures http://cvgmt.sns.it/paper/2781

Child-related career interruptions and the gender wage gap in France

In this paper, we investigate the extent of the effects of children and child-related time out of the labor market on the gender wage gap in France, with special attention to its impact on the accumulation and composition of human capital. Measuring this impact requires detailed information on the individuals‟ activity history that is rarely available. The French survey "Families and Employers" (Ined, 2005) provides this information. We first look at men's and women's wage determinants, including the penalties associated with unemployment and time out of the labor market. We find that having controlled for the jobs' characteristics and selection into employment, there is a penalty attached to child-related time out of the labor market, which affects only women. We do not find any direct negative impact of children on women's current hourly wage at the mean. Then for a sub-sample of men and women aged from 39 to 49, we use a decomposition of the gender wage gap into an "interruption" wage gap between women and a gender wage gap between women who have never taken child-related time out and men; we find that the wage gap between men and women who have never interrupted their participation in the labor force is essentially "unexplained", while the wage gap between women who have had child-related interruptions and women who have not is essentially "explained".Wages, Human capital, Children, Family pay gap, Statistical discrimination, Wage gap decomposition