"Context effects in a negative externality experiment"

This study investigates the degree to which framing and context influence observed rates of free-riding behavior in a negative externality laboratory experiment. Building on the work of Andreoni (1995a) and Messer et al. (2007) we frame the decision not to contribute to a public fund as generating a negative externality on other group members. The experimental treatments involving 252 subjects vary communication, voting, and the status quo of the initial endowment. Results indicate that allowing groups the opportunity to communicate and vote significantly reduces rates of free-riding, and this effect is especially pronounced when initial endowments are placed in the private as opposed to the public fund.Negative externality; voluntary contribution mechanism; cheap talk; voting; status quo bias; experimental economics

Creating topological interfaces and detecting chiral edge modes in a 2D optical lattice

We propose and analyze a general scheme to create chiral topological edge modes within the bulk of two-dimensional engineered quantum systems. Our method is based on the implementation of topological interfaces, designed within the bulk of the system, where topologically-protected edge modes localize and freely propagate in a unidirectional manner. This scheme is illustrated through an optical-lattice realization of the Haldane model for cold atoms, where an additional spatially-varying lattice potential induces distinct topological phases in separated regions of space. We present two realistic experimental configurations, which lead to linear and radial-symmetric topological interfaces, which both allows one to significantly reduce the effects of external confinement on topological edge properties. Furthermore, the versatility of our method opens the possibility of tuning the position, the localization length and the chirality of the edge modes, through simple adjustments of the lattice potentials. In order to demonstrate the unique detectability offered by engineered interfaces, we numerically investigate the time-evolution of wave packets, indicating how topological transport unambiguously manifests itself within the lattice. Finally, we analyze the effects of disorder on the dynamics of chiral and non-chiral states present in the system. Interestingly, engineered disorder is shown to provide a powerful tool for the detection of topological edge modes in cold-atom setups.Comment: 18 pages, 21 figure

Universality of Long-Range Correlations in Expansion-Randomization Systems

We study the stochastic dynamics of sequences evolving by single site mutations, segmental duplications, deletions, and random insertions. These processes are relevant for the evolution of genomic DNA. They define a universality class of non-equilibrium 1D expansion-randomization systems with generic stationary long-range correlations in a regime of growing sequence length. We obtain explicitly the two-point correlation function of the sequence composition and the distribution function of the composition bias in sequences of finite length. The characteristic exponent $\chi$ of these quantities is determined by the ratio of two effective rates, which are explicitly calculated for several specific sequence evolution dynamics of the universality class. Depending on the value of $\chi$, we find two different scaling regimes, which are distinguished by the detectability of the initial composition bias. All analytic results are accurately verified by numerical simulations. We also discuss the non-stationary build-up and decay of correlations, as well as more complex evolutionary scenarios, where the rates of the processes vary in time. Our findings provide a possible example for the emergence of universality in molecular biology.Comment: 23 pages, 15 figure

A Solvable Sequence Evolution Model and Genomic Correlations

We study a minimal model for genome evolution whose elementary processes are single site mutation, duplication and deletion of sequence regions and insertion of random segments. These processes are found to generate long-range correlations in the composition of letters as long as the sequence length is growing, i.e., the combined rates of duplications and insertions are higher than the deletion rate. For constant sequence length, on the other hand, all initial correlations decay exponentially. These results are obtained analytically and by simulations. They are compared with the long-range correlations observed in genomic DNA, and the implications for genome evolution are discussed.Comment: 4 pages, 4 figure

Crossovers from parity conserving to directed percolation universality

The crossover behavior of various models exhibiting phase transition to absorbing phase with parity conserving class has been investigated by numerical simulations and cluster mean-field method. In case of models exhibiting Z_2 symmetric absorbing phases (the NEKIMCA and Grassberger's A stochastic cellular automaton) the introduction of an external symmetry breaking field causes a crossover to kink parity conserving models characterized by dynamical scaling of the directed percolation (DP) and the crossover exponent: 1/\phi ~ 0.53(2). In case an even offspringed branching and annihilating random walk model (dual to NEKIMCA) the introduction of spontaneous particle decay destroys the parity conservation and results in a crossover to the DP class characterized by the crossover exponent: 1/\phi\simeq 0.205(5). The two different kinds of crossover operators can't be mapped onto each other and the resulting models show a diversity within the DP universality class in one dimension. These 'sub-classes' differ in cluster scaling exponents.Comment: 6 pages, 6 figures, accepted version in PR

A Finite Difference Representation of Neutrino Radiation Hydrodynamics in Spherically Symmetric General Relativistic Space-Time

We present an implicit finite difference representation for general relativistic radiation hydrodynamics in spherical symmetry. Our code, Agile-Boltztran, solves the Boltzmann transport equation for the angular and spectral neutrino distribution functions in self-consistent simulations of stellar core collapse and postbounce evolution. It implements a dynamically adaptive grid in comoving coordinates. Most macroscopically interesting physical quantities are defined by expectation values of the distribution function. We optimize the finite differencing of the microscopic transport equation for a consistent evolution of important expectation values. We test our code in simulations launched from progenitor stars with 13 solar masses and 40 solar masses. ~0.5 s after core collapse and bounce, the protoneutron star in the latter case reaches its maximum mass and collapses further to form a black hole. When the hydrostatic gravitational contraction sets in, we find a transient increase in electron flavor neutrino luminosities due to a change in the accretion rate. The muon- and tauon-neutrino luminosities and rms energies, however, continue to rise because previously shock-heated material with a non-degenerate electron gas starts to replace the cool degenerate material at their production site. We demonstrate this by supplementing the concept of neutrinospheres with a more detailed statistical description of the origin of escaping neutrinos. We compare the evolution of the 13 solar mass progenitor star to simulations with the MGFLD approximation, based on a recently developed flux limiter. We find similar results in the postbounce phase and validate this MGFLD approach for the spherically symmetric case with standard input physics.Comment: reformatted to 63 pages, 24 figures, to be published in ApJ

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of Rho-GTPases, Hippo-YAP/TAZ, or B lymphoma Mo-MLV insertion region 1 homolog (BMI1). Expression of ROR1 also enhanced the capacity of breast cancer cells to invade Matrigel, form spheroids, engraft in Rag2-/-[Formula: see text] mice, or survive treatment with paclitaxel. Treatment of mice bearing breast cancer patient-derived xenografts (PDXs) with the humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness, reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1, and impaired the capacity of breast cancer PDXs to metastasize or reengraft Rag2-/-[Formula: see text] mice. Finally, treatment of PDX-bearing mice with cirmtuzumab and paclitaxel was more effective than treatment with either alone in eradicating breast cancer PDXs. These results indicate that targeting ROR1 may improve the response to chemotherapy of patients with breast cancer

The Neutrino Signal in Stellar Core Collapse and Postbounce Evolution

General relativistic multi-group and multi-flavor Boltzmann neutrino transport in spherical symmetry adds a new level of detail to the numerical bridge between microscopic nuclear and weak interaction physics and the macroscopic evolution of the astrophysical object. Although no supernova explosions are obtained, we investigate the neutrino luminosities in various phases of the postbounce evolution for a wide range of progenitor stars between 13 and 40 solar masses. The signal probes the dynamics of material layered in and around the protoneutron star and is, within narrow limits, sensitive to improvements in the weak interaction physics. Only changes that dramatically exceed physical limitations allow experiments with exploding models. We discuss the differences in the neutrino signal and find the electron fraction in the innermost ejecta to exceed 0.5 as a consequence of thermal balance and weak equilibrium at the masscut.Comment: 8 pages, 4 figures. Proceedings of the Nuclear Physics in Astrophysics Conference, Debrecen, Hungary, 2002, to appear in Nuc. Phys. A. Color figures added and reference actualize