37 research outputs found
Isolated granulocytic sarcoma of the pancreas: A tricky diagnostic for primary pancreatic extramedullary acute myeloid leukemia
We report two clinical cases of primary granulocytic sarcoma of the pancreas that were diagnosed on the surgical specimen. Atypical clinical and morphological presentations may have lead to pretherapeutic biopsies of the pancreatic mass in order to indicate primary chemotherapy. Literature review of this rare clinical presentation may help physicians to anticipate diagnostic and therapeutic strategies
Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouracil-oxaliplatin-folinic acid (FOLFOX) for resectable esophageal and junctional cancer: the PROTECT-1402, randomized phase 2 trial.
BACKGROUND: Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one of the most commonly used chemotherapy regimens in this setting is a combination of a fluoropyrimidin and of a platinum analogue. Due to the promising results of the recent CROSS trial, another regimen combining paclitaxel and carboplatin is also widely used by European and American centers. No clinical study has shown the superiority of one treatment over the other. The objective of this Phase II study is to clarify clinical practice by comparing these two chemotherapy treatments. Our aim is to evaluate, in operable esophageal and gastro-esophageal junctional cancer, the complete resection rate and severe postoperative morbidity rate associated with these two neoadjuvant chemotherapeutic regimens (carboplatin-paclitaxel or fluorouracil-oxaliplatin-folinic acid) when each is combined with the radiation regime utilized in the CROSS trial.
METHODS/DESIGN: PROTECT is a prospective, randomized, multicenter, open arms, phase II trial. Eligible patients will have a histologically confirmed adenocarcinoma or squamous cell carcinoma and be treated with neoadjuvant radiochemotherapy followed by surgery for stage IIB or stage III resectable esophageal cancer. A total of 106 patients will be randomized to receive either 3 cycles of FOLFOX combined to concurrent radiotherapy (41.4 Grays) or carboplatin and paclitaxel with the same radiation regimen, using a 1:1 allocation ratio.
DISCUSSION: This ongoing trial offers the unique opportunity to compare two standards of chemotherapy delivered with a common regimen of preoperative radiation, in the setting of operable locally advanced esophageal or gastro-esophageal junctional tumors.
TRIAL REGISTRATION: NCT02359968 (ClinicalTrials.gov) (registration date: 9 FEB 2015), EudraCT: 2014-000649-62 (registration date: 10 FEB 2014)
Les hétérologies du savoir (Roland Barthes, Pascal Quignard)
The thing one observes moving from Roland Barthes to Pascal Quignard is the search for a sort of heterology of knowledge; the emphasis of an âotherâ discourse on knowledge or rather the spectacular display of a heterodox form for the writing of knowledge. This takes place by means of the intertwinement of both narrative and argumentative registers, as well as by the choice of a more fragmented rather than dissertational form, by a sort of openness to enunciation games but also by the incorporation of short fictional excerpts within the margins of such prose of ideas and finally by pondering the figural dimension deeply operating the writing of the theoretical text. The comparison initiated herewith between these two generations of writers has led us to put forward a genealogical approach of such âheterologicalâ restoration of knowledge by literature. The question was outlined as follows: what does the insistence of the use by the literary of a scholar discourse literalization tell us, in its own way, concerning the very idea literature projects of itself? Underlying all the annexations of scholarly disciplines within the field of literature â indeed exclusively conducted from literature's point of view, in an almost unanimous indifference towards âscienceâ whose emancipation no longer needs to be claimed â one asks whether there would not be a complete symbolic turnaround strategy of both the power and the figure of the literary. We do not aim at contributing to the history of literature â whose plan, often too wide, ends by essentializing the precise object it seeks to historicize â but rather to participating in the history of an idea of literature itself; and herewith, in a more strict manner, attempting to enlighten the history of the idea that recent literature has (once again) sought sovereignty within the order of discourse.De Roland Barthes Ă Pascal Quignard, ce que lâon observe câest la recherche dâune hĂ©tĂ©rologie du savoir ; lâaccentuation dâun discours « autre » sur le savoir ou plutĂŽt la spectacularisation dâune forme hĂ©tĂ©rodoxe de lâĂ©criture du savoir. Cela passe par le mĂ©lange des registres narratifs et argumentatifs, par le choix dâune forme plus fragmentaire que dissertative, par lâouverture aux jeux Ă©nonciatifs comme par lâaccueil de courts passages fictionnels dans les marges de la prose dâidĂ©es, par le souci enfin de la dimension figurale qui travaille en profondeur lâĂ©criture du texte thĂ©orique. En engageant une comparaison entre ces deux gĂ©nĂ©rations dâĂ©crivains, nous avons tentĂ© une approche gĂ©nĂ©alogique de cette ressaisie « hĂ©tĂ©rologique » des savoirs par la littĂ©rature. La question a Ă©tĂ© la suivante : quâest-ce que lâinsistance de la littĂ©rarisation du discours savant par les littĂ©raires nous dit, en retour, de lâidĂ©e que la littĂ©rature se fait dâelle-mĂȘme ? DerriĂšre toutes ces annexions des disciplines savantes dans le domaine de la littĂ©rature â dâailleurs exclusivement menĂ©es depuis la littĂ©rature, dans une indiffĂ©rence quasi unanime de la « science » dont lâĂ©mancipation nâa plus Ă ĂȘtre revendiquĂ©e â nây-a-t-il pas toute une stratĂ©gie de redressement symbolique du pouvoir et de la figure du littĂ©raire ? Il ne sâagit pas ici dâune contribution Ă lâhistoire de la littĂ©rature â dont le plan, souvent trop vaste, finit par essentialiser lâobjet quâelle se propose prĂ©cisĂ©ment dâhistoriciser â, mais plutĂŽt dâune participation Ă lâhistoire de lâidĂ©e de littĂ©rature ; et Ă lâintĂ©rieur de celle-ci, de façon plus resserrĂ©e encore, la tentative dâĂ©clairer lâhistoire de lâidĂ©e selon laquelle la littĂ©rature rĂ©cente sâest voulue (de nouveau) souveraine dans lâordre des discours
Monts jumeaux
International audienceĂric Marty publie un court rĂ©cit dans lequel le texte et lâimage dialoguent et se redoublent sans jamais se recouvrir complĂštement. Les photographies de Jean-Jacques Gonzales, beaux clichĂ©s en noir et blanc reprĂ©sentant des chemins de pierre ouverts sur un pur espace, esquissent un dĂ©sert insituable qui sert ici de cadre Ă la fiction de lâĂ©crivain
LâĆuvre entĂȘtĂ©e: (Ă propos de : Pascal Quignard, "Lâenfant dâIngolstadt")
International audienc
Une langue en flammes: (Ă propos de La vie nâest pas une biographie de Pascal Quignard)
International audienceOuvrir La vie nâest pas une biographie, nouvel opus de Pascal Quignard, câest Ă©prouver lâĂ©trange sensation dâĂȘtre immĂ©diatement plongĂ©s dans la mĂȘme Ă©criture, au milieu dâune sĂ©quence qui a dĂ©jĂ commencĂ© depuis longtemps et qui, pourtant, sans cesse recommence. Câest une nouvelle fois la chance de se retrouver face Ă lâune de ces rares Ćuvres qui se laissent contempler Ă marĂ©e haute
The Heterologies of Knowledge (Roland Barthes, Pascal Quignard)
De Roland Barthes Ă Pascal Quignard, ce que lâon observe câest la recherche dâune hĂ©tĂ©rologie du savoir ; lâaccentuation dâun discours « autre » sur le savoir ou plutĂŽt la spectacularisation dâune forme hĂ©tĂ©rodoxe de lâĂ©criture du savoir. Cela passe par le mĂ©lange des registres narratifs et argumentatifs, par le choix dâune forme plus fragmentaire que dissertative, par lâouverture aux jeux Ă©nonciatifs comme par lâaccueil de courts passages fictionnels dans les marges de la prose dâidĂ©es, par le souci enfin de la dimension figurale qui travaille en profondeur lâĂ©criture du texte thĂ©orique. En engageant une comparaison entre ces deux gĂ©nĂ©rations dâĂ©crivains, nous avons tentĂ© une approche gĂ©nĂ©alogique de cette ressaisie « hĂ©tĂ©rologique » des savoirs par la littĂ©rature. La question a Ă©tĂ© la suivante : quâest-ce que lâinsistance de la littĂ©rarisation du discours savant par les littĂ©raires nous dit, en retour, de lâidĂ©e que la littĂ©rature se fait dâelle-mĂȘme ? DerriĂšre toutes ces annexions des disciplines savantes dans le domaine de la littĂ©rature â dâailleurs exclusivement menĂ©es depuis la littĂ©rature, dans une indiffĂ©rence quasi unanime de la « science » dont lâĂ©mancipation nâa plus Ă ĂȘtre revendiquĂ©e â nây-a-t-il pas toute une stratĂ©gie de redressement symbolique du pouvoir et de la figure du littĂ©raire ? Il ne sâagit pas ici dâune contribution Ă lâhistoire de la littĂ©rature â dont le plan, souvent trop vaste, finit par essentialiser lâobjet quâelle se propose prĂ©cisĂ©ment dâhistoriciser â, mais plutĂŽt dâune participation Ă lâhistoire de lâidĂ©e de littĂ©rature ; et Ă lâintĂ©rieur de celle-ci, de façon plus resserrĂ©e encore, la tentative dâĂ©clairer lâhistoire de lâidĂ©e selon laquelle la littĂ©rature rĂ©cente sâest voulue (de nouveau) souveraine dans lâordre des discours.The thing one observes moving from Roland Barthes to Pascal Quignard is the search for a sort of heterology of knowledge; the emphasis of an âotherâ discourse on knowledge or rather the spectacular display of a heterodox form for the writing of knowledge. This takes place by means of the intertwinement of both narrative and argumentative registers, as well as by the choice of a more fragmented rather than dissertational form, by a sort of openness to enunciation games but also by the incorporation of short fictional excerpts within the margins of such prose of ideas and finally by pondering the figural dimension deeply operating the writing of the theoretical text. The comparison initiated herewith between these two generations of writers has led us to put forward a genealogical approach of such âheterologicalâ restoration of knowledge by literature. The question was outlined as follows: what does the insistence of the use by the literary of a scholar discourse literalization tell us, in its own way, concerning the very idea literature projects of itself? Underlying all the annexations of scholarly disciplines within the field of literature â indeed exclusively conducted from literature's point of view, in an almost unanimous indifference towards âscienceâ whose emancipation no longer needs to be claimed â one asks whether there would not be a complete symbolic turnaround strategy of both the power and the figure of the literary. We do not aim at contributing to the history of literature â whose plan, often too wide, ends by essentializing the precise object it seeks to historicize â but rather to participating in the history of an idea of literature itself; and herewith, in a more strict manner, attempting to enlighten the history of the idea that recent literature has (once again) sought sovereignty within the order of discourse
L'origine de la danse: (Ă propos de "L'Origine de la danse" de Pascal Quignard)
International audienceNote de lectur
Pourquoi le XXe siÚcle a-t-il pris le sexe au sérieux ?: A propos du "Sexe des Modernes" (Eric Marty)
International audienceDans "Le sexe des Modernes", Ăric Marty dĂ©mĂȘle les racines intellectuelles qui sont Ă lâorigine de lâexpansion du concept de « genre » dans lâunivers culturel de la fin du XXe siĂšcle. Ă cheval entre lâEurope et les Ătats-Unis, cette enquĂȘte constitue la premiĂšre cartographie complĂšte des territoires thĂ©oriques sur lesquels a germĂ© une pensĂ©e du sexe qui brouille lâordre classique des reprĂ©sentations
Pourquoi le XXe siÚcle a-t-il pris le sexe au sérieux ?: A propos du "Sexe des Modernes" (Eric Marty)
International audienceDans "Le sexe des Modernes", Ăric Marty dĂ©mĂȘle les racines intellectuelles qui sont Ă lâorigine de lâexpansion du concept de « genre » dans lâunivers culturel de la fin du XXe siĂšcle. Ă cheval entre lâEurope et les Ătats-Unis, cette enquĂȘte constitue la premiĂšre cartographie complĂšte des territoires thĂ©oriques sur lesquels a germĂ© une pensĂ©e du sexe qui brouille lâordre classique des reprĂ©sentations