Assessing framing assumptions in quantitative health impact assessments: a housing intervention example.

Health impact assessment (HIA) is often used to determine ex ante the health impact of an environmental policy or an environmental intervention. Underpinning any HIA is the framing assumption, which defines the causal pathways mapping environmental exposures to health outcomes. The sensitivity of the HIA to the framing assumptions is often ignored. A novel method based on fuzzy cognitive map (FCM) is developed to quantify the framing assumptions in the assessment stage of a HIA, and is then applied to a housing intervention (tightening insulation) as a case-study. Framing assumptions of the case-study were identified through a literature search of Ovid Medline (1948-2011). The FCM approach was used to identify the key variables that have the most influence in a HIA. Changes in air-tightness, ventilation, indoor air quality and mould/humidity have been identified as having the most influence on health. The FCM approach is widely applicable and can be used to inform the formulation of the framing assumptions in any quantitative HIA of environmental interventions. We argue that it is necessary to explore and quantify framing assumptions prior to conducting a detailed quantitative HIA during the assessment stage

Area Littlewood-Paley functions associated with Hermite and Laguerre operators

In this paper we study Lp-boundedness properties for area Littlewood-Paley functions associated with heat semigroups for Hermite and Laguerre operator

'Getting out of the closet': Scientific authorship of literary fiction and knowledge transfer

Some scientists write literary fiction books in their spare time. If these books contain scientific knowledge, literary fiction becomes a mechanism of knowledge transfer. In this case, we could conceptualize literary fiction as non-formal knowledge transfer. We model knowledge transfer via literary fiction as a function of the type of scientist (academic or non-academic) and his/her scientific field. Academic scientists are those employed in academia and public research organizations whereas non-academic scientists are those with a scientific background employed in other sectors. We also distinguish between direct knowledge transfer (the book includes the scientist's research topics), indirect knowledge transfer (scientific authors talk about their research with cultural agents) and reverse knowledge transfer (cultural agents give scientists ideas for future research). Through mixed-methods research and a sample from Spain, we find that scientific authorship accounts for a considerable percentage of all literary fiction authorship. Academic scientists do not transfer knowledge directly so often as non-academic scientists, but the former engage into indirect and reverse transfer knowledge more often than the latter. Scientists from History stand out in direct knowledge transfer. We draw propositions about the role of the academic logic and scientific field on knowledge transfer via literary fiction. We advance some tentative conclusions regarding the consideration of scientific authorship of literary fiction as a valuable knowledge transfer mechanism.Comment: Paper published in Journal of Technology Transfe

A Consistent Spectral Model of WR 136 and its Associated Bubble NGC 6888

We analyse whether a stellar atmosphere model computed with the code CMFGEN provides an optimal description of the stellar observations of WR 136 and simultaneously reproduces the nebular observations of NGC 6888, such as the ionization degree, which is modelled with the pyCloudy code. All the observational material available (far and near UV and optical spectra) were used to constrain such models. We found that even when the stellar luminosity and the mass-loss rate were well constrained, the stellar temperature T_* at tau = 20, can be in a range between 70 000 and 110 000 K. When using the nebula as an additional restriction we found that the stellar models with T_* \sim 70 000 K represent the best solution for both, the star and the nebula. Results from the photoionization model show that if we consider a chemically homogeneous nebula, the observed N^+/O^+ ratios found in different nebular zones can be reproduced, therefore it is not necessary to assume a chemical inhomogeneous nebula. Our work shows the importance of calculating coherent models including stellar and nebular constraints. This allowed us to determine, in a consistent way, all the physical parameters of both the star and its associated nebula. The chemical abundances derived are 12 + log(N/H) = 9.95, 12 + log(C/H) = 7.84 and 12 + log(O/H) = 8.76 for the star and 12 + log(N/H) = 8.40, 12 + log(C/H) = 8.86 and 12 + log(O/H) = 8.20. Thus the star and the nebula are largely N- and C- enriched and O-depleted.Comment: 17 pages, 8 figures, 8 tables; MNRAS accepte

Connection between type B (or C) and F factorizations and construction of algebras

In a recent paper (Del Sol Mesa A and Quesne C 2000 J. Phys. A: Math. Gen. 33 4059), we started a systematic study of the connections among different factorization types, suggested by Infeld and Hull, and of their consequences for the construction of algebras. We devised a general procedure for constructing satellite algebras for all the Hamiltonians admitting a type E factorization by using the relationship between type A and E factorizations. Here we complete our analysis by showing that for Hamiltonians admitting a type F factorization, a similar method, starting from either type B or type C ones, leads to other types of algebras. We therefore conclude that the existence of satellite algebras is a characteristic property of type E factorizable Hamiltonians. Our results are illustrated with the detailed discussion of the Coulomb problem.Comment: minor changes, 1 additional reference, final form to be published in JP

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.

BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation. I-R injury can induce lung dysfunction whether the I-R occurs in the lung or in a remote organ. Recently, evidence has emerged that receptors and pathways of the innate immune system are involved in recognizing sterile inflammation and overlap considerably with those involved in the recognition of and response to pathogens.MethodsThe authors used a mouse surgical model of transient unilateral left pulmonary artery occlusion without bronchial involvement to create ventilated lung I-R injury. In addition, they mimicked nutritional I-R injury in vitro by transiently depriving cells of all nutrients.ResultsCompared with sham-operated mice, mice subjected to ventilated lung I-R injury had up-regulated lung expression of inflammatory mediator messenger RNA for interleukin-1β, interleukin-6, and chemokine (C-X-C motif) ligand-1 and -2, paralleled by histologic evidence of lung neutrophil recruitment and increased plasma concentrations of interleukin-1β, interleukin-6, and high-mobility group protein B1 proteins. This inflammatory response to I-R required toll-like receptor-4 (TLR4). In addition, the authors demonstrated in vitro cooperativity and cross-talk between human macrophages and endothelial cells, resulting in augmented inflammatory responses to I-R. Remarkably, the authors found that selective depletion of alveolar macrophages rendered mice resistant to ventilated lung I-R injury.ConclusionsThe data reveal that alveolar macrophages and the pattern recognition receptor toll-like receptor-4 are involved in the generation of the early inflammatory response to lung I-R injury

The orientation of galaxy pairs with filamentary structures: dependence on morphology

Aims. With the aim of performing an analysis of the orientations of galaxy pair systems with respect to the underlying large-scale structure, we study the alignment between the axis connecting the pair galaxies and the host cosmic filament where the pair resides. In addition, we analyze the dependence of the amplitude of the alignment on the morphology of pair members as well as filament properties. Methods. We build a galaxy pair catalog requiring r_p < 100\kpc and \Delta V < 500 \kms within redshift $z<0.1$ from the Sloan Digital Sky Survey (SDSS). We divided the galaxy pair catalog taking into account the morphological classification by defining three pair categories composed by elliptical-elliptical (E-E), elliptical-spiral (E-S) and spiral-spiral (S-S) galaxies. We use a previously defined catalog of filaments obtained from SDSS and we select pairs located closer than 1\mpc from the filament spine, which are considered as members of filaments. For these pairs, we calculate the relative angle between the axis connecting each galaxy, and the direction defined by the spine of the parent filament. Results. We find a statistically significant alignment signal between the pair axes and the spine of the host filaments consistent with a relative excess of $\sim$ 15\% aligned pairs. We obtain that pairs composed by elliptical galaxies exhibit a stronger alignment, showing a higher alignment signal for pairs closer than 200 \kpc to the filament spine. In addition, we find that the aligned pairs are associated with luminous host filaments populated with a high fraction of elliptical galaxies. The findings of this work show that large scale structures play a fundamental role in driving galactic anisotropic accretion as induced by galaxy pairs exhibiting a preferred alignment along the filament direction.Comment: 8 pages, 6 figures. Accepted for publication in A&

Polarization Properties of Extragalactic Radio Sources and Their Contribution to Microwave Polarization Fluctuations

We investigate the statistical properties of the polarized emission of extragalactic radio sources and estimate their contribution to the power spectrum of polarization fluctuations in the microwave region. The basic ingredients of our analysis are the NVSS polarization data, the multifrequency study of polarization properties of the B3-VLA sample (Mack et al. 2002) which has allowed us to quantify Faraday depolarization effects, and the 15 GHz survey by Taylor et al. (2001), which has provided strong constraints on the high-frequency spectral indices of sources. The polarization degree of both steep- and flat-spectrum at 1.4 GHz is found to be anti-correlated with the flux density. The median polarization degree at 1.4 GHz of both steep- and flat-spectrum sources brighter than $S(1.4 \hbox{GHz})=80$mJy is $\simeq 2.2$. The data by Mack et al. (2002) indicate a substantial mean Faraday depolarization at 1.4 GHz for steep spectrum sources, while the depolarization is undetermined for most flat/inverted-spectrum sources. Exploiting this complex of information we have estimated the power spectrum of polarization fluctuations due to extragalactic radio sources at microwave frequencies. We confirm that extragalactic sources are expected to be the main contaminant of Cosmic Microwave Background (CMB) polarization maps on small angular scales. At frequencies $< 30$GHz the amplitude of their power spectrum is expected to be comparable to that of the $E$-mode of the CMB. At higher frequencies, however, the CMB dominates.Comment: 10 pages, A&A in pres