Valorization of two biological materials in the treatment of tannery effluents by filtration

The present study aims at the valorization of two natural materials such as marine sand and wood sawdust in the treatment of tannery effluents taken directly from an industrial unit located in the Dokkarat, district of Fez. The technique used is that of column filtration. Physicochemical characterization such as COD,,  Cr, etc. as well as microbiological analysis such as total germs (TG), Total Coliforms (TC), Faecal Coliforms (FC), etc. of the effluent, before and after filtration by the two supports used, were performed. The two filtering materials were previously characterized by DRX, IR-FTIR and SEM-EDX. The results obtained show that the latter two are effective in the treatment of the effluent, especially with the wood sawdust filter. Indeed, the removal rate (RR) of COD,, SS, EC,  and Cr is in the order of 90.79%, 86.04%, 83.3%, 80%, 96.7% and 84.07% for the sawdust filter, while for the marine sand filter these values are of 81.5%, 79.9%, 79.2%, 66.6%, 94.4% and 56.15%, respectively

Morphometry, Oil Yield and Fatty Acid Profile of Cannabis Achenes from the Chefchaouen Region

The achenes evaluated had average dimensions of 4. 242 ± 0. 329 mm long, 3. 38 ± 0. 294 mm wide, 2.75 ± 0. 227 mm thick. They contained an average moisture of 7. 614 ± 1. 623 and an average mass of 0.01808 ± 0. 0038 g. No significant differences in the yields of the oil obtained by hexane and press extraction (p-value>0. 05), they varied respectively from 31. 36 % ± 0. 05 to 36. 86 % ± 1. 79 and 21. 47% ± 2. 45 to 25. 04 % ± 0. 46. Among the fatty acids in the mechanically extracted vegetable oil from the five achene varieties, the order of abundance of the identified components was the same. The linoleic acids they account for more than 86 % of the total α-predominant fatty acids are linoleic and fatty acids. PUFA/SFA ratio ranged from 5. 5 ± 1. 58 to 8. 96 ± 0. 23. The n-6/n-3 ratio varied from 1. 53 ± 0. 02 to 1. 78 ± 0. 0. The quotients recorded in our study are likely to be of nutritional interest since a ratio between 1/1 and 2/1 is considered ideal

Deciphering the SARS-CoV-2 Delta Variant: Antiviral Compound Efficacy by Molecular Docking, ADMET, and Dynamics Studies

This research was conducted to discover potential antiviral compounds effective against the Delta variant of SARS-CoV-2 through computational screening methods. Our investigation encompassed nine established antiviral medications—Ritonavir, Remdesivir, Lopinavir, Ivermectin, Favipiravir, Ribavirin, Clofoctol, Chlorpromazine, and Artemisinin—and a flavone derivative, 2-(4-((6-hydroxyhexyl)oxy)phenyl)-4H-chroman-4-one (4c). These compounds were evaluated for their binding affinity to the Delta variant’s spike protein and their stability within the complex. We also examined their ADMET profiles and pharmacokinetic properties. he study found that all compounds exhibited strong binding to key amino acid residues within the spike protein’s active site, potentially inhibiting the enzyme’s function. Binding energy values ranged from -3.966 to -6.392 kcal/mol for the for the known drugs, with the flavone derivative exhibiting the highest binding affinity of -7.895 kcal/mol and an optimal ADMET profile. Molecular dynamics simulations further confirmed the stability of the 4c-spike protein complex. Our results indicate that the flavone derivative 4c is a promising lead for the development of novel antiviral therapies targeting the Delta variant of SARS-CoV-2

In silico evaluation of antiviral activity of flavone derivatives and commercial drugs against SARS-CoV-2 main protease (3CLpro).

In this paper the in silco evaluation of the antiviaral activity against the current spread of severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) of several anti-viral components such as Chloroquine, Simeprevir, Lopinavir and a series of five natural and synthesized flavone derivative was investigated.Results of the molecular docking revealed that among of the five flavones studied and Chloroquine, Simeprevir and Lopinavir, three compounds correlate with a high affinity for the same binding sites with the major protein 3-chymotrypsin-like protease (3CLpro) and a small negative binding energy compared with the control N3 molecule in protein 6LU7 and the control WK1 molecule in protein 2OP9. This may disrupt the 3CLpro main protease function and efficiency

Functional and Behavior Models for the Supervision of an Intelligent and Autonomous System

The graphical approaches often have different backgrounds and view a system or an algebraic model from different perspectives in order to facilitate the communication and the understanding. These graphical approaches satisfy the modeling needs and give a clear and easily understandable overview of the behavioral and functional models and make easier to see what the process is, which vulnerabilities and asset that are involved and how the system works. The main goal of this paper is to develop and implement a methodology which combines the functional analysis and the bond graph (BG) tool for intelligent and autonomous systems. As a result, a supervisory interface is obtained, given under a finite automaton, displaying to the operators the possibilities the system has to achieve or not, its objectives. Each operating mode, corresponding to a vertex of the automaton, is associated with a set of services from a functional point-of-view and is defined accurately by a behavioral BG model. Furthermore, the service availability (associated to the BG elements) and the conditions for switching from one mode to another one are analyzed by fault detection and isolation algorithms generated on the basis of the structural and causal properties of the BG tool. Moreover, when a fault is not completely isolable some results can nevertheless be expressed in terms of available or unavailable services

Potential inhibition of ALDH by argan oil compounds, computational approach by docking, ADMET and molecular dynamics

Actuellement, les choix pour traiter l'alcoolisme sont limités, le disulfirame étant la principale option, malgré son lien notable avec les effets indésirables (Chick et al., 1992 ; Ho et al., 2007 ; Hughes et Cook, 1997 ; Kleczkowska et al., 2021) . Ainsi, l'objectif principal de cette étude est d'explorer des voies de traitement alternatives. Pour atteindre cet objectif, nous avons examiné l'impact de l'huile d'argan et de composés spécifiques, reconnus pour leur présence importante dans l'huile, sur le métabolisme de l'alcool. Cette exploration impliquait d'évaluer l'affinité et la stabilité de ces molécules avec l'ALDH, une enzyme cruciale dans le métabolisme de l'alcool, en utilisant des outils informatiques tels que "AutoDock Vina, ( Morris et al., 2008) ", "Desmond" et des logiciels similaires (Daina et al. , 2017 ; Pires et al., 2015) et en examinant l'influence de l'huile d'argan sur les changements temporels du taux d'alcoolémie en utilisant un kit de mesure du taux d'alcoolémie. Les résultats des deux segments étaient encourageants, car l'affinité collective des molécules avec l'ALDH dépassait celle de la molécule de référence « disulfirame ». Notamment, l'alpha-tocophérol et le spinastérol ont présenté une stabilité supérieure. En phase pratique, l'huile d'argan, associée à ces molécules, a réduit significativement le taux d'alcoolémie par rapport au groupe témoin. Il reste encore à accomplir une utilisation plus complète de ces résultats pour mieux comprendre les mécanismes qui sous-tendent les effets positifs du pétrole. Cela pourrait normalement ouvrir la voie à de futures recherches visant à explorer l'huile comme traitement viable contre l'alcoolisme

Modelos de endemicidad a lo largo de un gradiente altitudinal en Sierra Nevada (España) y Lefka Ori (Creta, Grecia)

Aim: High mountains in the Mediterranean region of Europe are particularly rich in endemic vascular plants. We aimed to compare the altitudinal patterns of vascular plant species richness and the proportion of endemic species in two Mediterranean region: Lefka Ori on the island of Crete (Greece) and Sierra Nevada on the Iberian peninsula. Location: Sierra Nevada, Granada (Spain); Lefka Ori, Crete (Greece). Methods: Data from standardised permanent plots settings on summit sites (comprising eight plot sectors, covering the upeermost 10 altitudinal metres) of different elevations were used (GLORIA Multi-Summit approach; www.gloria.ac.at). Species numbers, rates of endemic species, and soils temperature were compared by means of ANCOVA and linear regression. Results: The two regions, though climatically similar, showed strikingly different patterns: In Sierra Nevada, the proportion of endemic vascular plants (species restricted to Sierra Nevada) showed a stepwise increase from the lowest to the highest summit. In contrast, the proportion of endemic species restricted to Crete was not significantly different between the four summits in Lefka Ori. In both regions the observed trends were largely consistent with the altitudinal distribution of the endemic species obtained from standard floras. Main conclusions: The geographic positions of the two regions, i.e. island versus mainland and the higher elevation of Sierra Nevada are suggested to be the primary causes of the observed differences. The high degree of endemism in the cold environments of Mediterranean mountains’ upper bioclimatic zones indicates a pronounced vulnerability to the impacts of climate change. A continued and intensified species monitoring in the mountains around the Mediterranean basin, therefore, should be considered as a priority research task.Objetivo: Las zonas de alta montaña en la región mediterránea europea son particularmente ricas en plantas vasculares endémicas. Nuestro objetivo es comparar los modelos altitudinales para la riqueza de plantas vasculares y la proporción de endemismos en dos regiones mediterráneas: Lefka Ori en la isla de Creta (Grecia) y Sierra Nevada en la Península Ibérica. Localización: Sierra Nevada, Granada (España); Lefka Ori, Creta (Grecia). Método: Los datos proceden de un muestreo estandarizado en varias cimas situadas a diferentes altitudes (GLORIA Multi-Summit approach; www.gloria.ac.at). El número de especies, tasas de endemicidad, y temperatura del suelo se compararon por medio de ANCOVA y regresión lineal. Resultados: Las dos regiones objeto de análisis, aunque similares climáticamente, muestran patrones llamativamente diferentes: en Sierra Nevada, la proporción de plantas vasculares endémicas (especies restringidas a Sierra Nevada) muestra un incremento gradual desde la cima más baja a la más alta. En contraste, la proporción de endemismos restringidos a Creta no fue significativamente diferente entre las cuatro cimas de Lefka Ori. Las tendencias observadas en ambas regiones fueron en gran parte consistentes con la distribución de las especies endémicas obtenida de las floras para cada región. Conclusiones principales: La posición geográfica de ambas regiones, por ejemplo. isla frente a continente, y la mayor elevación de Sierra Nevada se sugieren como las principales causas de las diferencias observadas. El alto grado de endemicidad en los ambientes fríos de las zonas bioclimáticas superiores de las montañas mediterráneas evidencia una marcada vulnerabilidad a los impactos del cambio climático. Por lo tanto, el seguimiento continuado e intensivo de las especies de montaña alrededor de la cuenca mediterránea, debería considerarse como una tarea investigadora prioritaria.He set up of the permanent plots and data collection was supported by the FP-5 project GLORIA-Europe (2001-2003) No EVK2-2000-00056 of the European Commission

Compact bionic handling arm control using neural networks

International audienc