One Dimensional Chain with Long Range Hopping

The one-dimensional (1D) tight binding model with random nearest neighbor hopping is known to have a singularity of the density of states and of the localization length at the band center. We study numerically the effects of random long range (power-law) hopping with an ensemble averaged magnitude \expectation{|t_{ij}|} \propto |i-j|^{-\sigma} in the 1D chain, while maintaining the particle-hole symmetry present in the nearest neighbor model. We find, in agreement with results of position space renormalization group techniques applied to the random XY spin chain with power-law interactions, that there is a change of behavior when the power-law exponent $\sigma$ becomes smaller than 2

On the Incommensurate Phase of Pure and Doped Spin-Peierls System CuGeO_3

Phases and phase transitions in pure and doped spin-Peierls system CuGeO_3 are considered on the basis of a Landau-theory. In particular we discuss the critical behaviour, the soliton width and the low temperature specific heat of the incommensurate phase. We show, that dilution leads always to the destruction of long range order in this phase, which is replaced by an algebraic decay of correlations if the disorder is weak.Comment: 4 pages revtex, no figure

Acoustic Cyclotron Resonance and Giant High Frequency Magnetoacoustic Oscillations in Metals with Locally Flattened Fermi Surface

We consider the effect of local flattening on the Fermi surface (FS) of a metal upon geometric oscillations of the velocity and attenuation of ultrasonic waves in the neighborhood of the acoustic cyclotron resonance. It is shown that such peculiarities of the local geometry of the FS can lead to a significant enhancement of both cyclotron resonance and geometric oscillations. Characteristic features of the coupling of ultrasound to shortwave cyclotron waves arising due to the local flattening of the FS are analyzed. PACS numbers 71.18.+y; 72.15.Gd; 72.15.-vComment: 8 pages, 3 figures, text revise

Exact results for quantum phase transitions in random XY spin chains

The effect of disorder on the quantum phase transitions induced by a transverse field, anisotropy, and dimerization in XY spin chains is investigated. The low-energy behavior near the critical point is described by a Dirac-type equation with a random mass for which an exact analytic treatment is possible. Results obtained for the dynamical critical exponent, the specific heat, and transverse susceptibility agree with results recently obtained using a real space renormalization group decimation technique, supporting Fisher's claim that it is exact. A non-zero transverse field changes the universality class of the anisotropy transition.Comment: 5 pages, RevTeX + epsf, 2 figures

Phonons in random alloys: the itinerant coherent-potential approximation

We present the itinerant coherent-potential approximation(ICPA), an analytic, translationally invariant and tractable form of augmented-space-based, multiple-scattering theory in a single-site approximation for harmonic phonons in realistic random binary alloys with mass and force-constant disorder. We provide expressions for quantities needed for comparison with experimental structure factors such as partial and average spectral functions and derive the sum rules associated with them. Numerical results are presented for Ni_{55} Pd_{45} and Ni_{50} Pt_{50} alloys which serve as test cases, the former for weak force-constant disorder and the latter for strong. We present results on dispersion curves and disorder-induced widths. Direct comparisons with the single-site coherent potential approximation(CPA) and experiment are made which provide insight into the physics of force-constant changes in random alloys. The CPA accounts well for the weak force-constant disorder case but fails for strong force-constant disorder where the ICPA succeeds.Comment: 19 pages, 12 eps figures, uses RevTex

Density of Neutral Solitons in Weakly Disordered Peierls Chains

We study the effects of weak off-diagonal disorder on Peierls systems with a doubly degenerate ground state. We show that for these systems disorder in the electron hopping amplitudes induces a finite density of solitons in the minimal-energy lattice configuration of a single chain. These disorder-induced dimerization kinks are neutral and have spin 1/2. Using a continuum model for the Peierls chain and treating the lattice classically, we analytically calculate the average free energy and density of kinks. We compare these results to numerical calculations for a discrete model and discuss the implications of the kinks for the optical and magnetic properties of the conjugated polymer trans-polyacetylene.Comment: 28 pages, revtex, 5 Postscript figures, to appear in Phys. Rev.

Effect of disorder on quantum phase transitions in anisotropic XY spin chains in a transverse field

We present some exact results for the effect of disorder on the critical properties of an anisotropic XY spin chain in a transverse field. The continuum limit of the corresponding fermion model is taken and in various cases results in a Dirac equation with a random mass. Exact analytic techniques can then be used to evaluate the density of states and the localization length. In the presence of disorder the ferromagnetic-paramagnetic or Ising transition of the model is in the same universality class as the random transverse field Ising model solved by Fisher using a real space renormalization group decimation technique (RSRGDT). If there is only randomness in the anisotropy of the magnetic exchange then the anisotropy transition (from a ferromagnet in the $x$ direction to a ferromagnet in the $y$ direction) is also in this universality class. However, if there is randomness in the isotropic part of the exchange or in the transverse field then in a non-zero transverse field the anisotropy transition is destroyed by the disorder. We show that in the Griffiths' phase near the Ising transition that the ground state energy has an essential singularity. The results obtained for the dynamical critical exponent, the typical correlation length, and the temperature dependence of the specific heat near the Ising transition agree with the results of the RSRGDT and numerical work.Comment: 22 pages, RevTeX + epsf, 4 figure

In situ guided tissue regeneration in musculoskeletal diseases and aging: Implementing pathology into tailored tissue engineering strategies

In situ guided tissue regeneration, also addressed as in situ tissue engineering or endogenous regeneration, has a great potential for population-wide “minimal invasive” applications. During the last two decades, tissue engineering has been developed with remarkable in vitro and preclinical success but still the number of applications in clinical routine is extremely small. Moreover, the vision of population-wide applications of ex vivo tissue engineered constructs based on cells, growth and differentiation factors and scaffolds, must probably be deemed unrealistic for economic and regulation-related issues. Hence, the progress made in this respect will be mostly applicable to a fraction of post-traumatic or post-surgery situations such as big tissue defects due to tumor manifestation. Minimally invasive procedures would probably qualify for a broader application and ideally would only require off the shelf standardized products without cells. Such products should mimic the microenvironment of regenerating tissues and make use of the endogenous tissue regeneration capacities. Functionally, the chemotaxis of regenerative cells, their amplification as a transient amplifying pool and their concerted differentiation and remodeling should be addressed. This is especially important because the main target populations for such applications are the elderly and diseased. The quality of regenerative cells is impaired in such organisms and high levels of inhibitors also interfere with regeneration and healing. In metabolic bone diseases like osteoporosis, it is already known that antagonists for inhibitors such as activin and sclerostin enhance bone formation. Implementing such strategies into applications for in situ guided tissue regeneration should greatly enhance the efficacy of tailored procedures in the future

IL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway

Interleukin-7 (IL-7) concentrations are increased in the blood of CD4+ T cell depleted individuals, including HIV-1 infected patients. High IL-7 levels might stimulate T cell activation and, as we have shown earlier, IL-7 can prime resting T cell to CD95 induced apoptosis as well. HIV-1 infection leads to B cell abnormalities including increased apoptosis via the CD95 (Fas) death receptor pathway and loss of memory B cells. Peripheral B cells are not sensitive for IL-7, due to the lack of IL-7Ra expression on their surface; however, here we demonstrate that high IL-7 concentration can prime resting B cells to CD95-mediated apoptosis via an indirect mechanism. T cells cultured with IL-7 induced high CD95 expression on resting B cells together with an increased sensitivity to CD95 mediated apoptosis. As the mediator molecule responsible for B cell priming to CD95 mediated apoptosis we identified the cytokine IFN-γ that T cells secreted in high amounts in response to IL-7. These results suggest that the lymphopenia induced cytokine IL-7 can contribute to the increased B cell apoptosis observed in HIV-1 infected individuals

Advances, gaps and way forward in provision of climate services over the Greater Horn of Africa

The Greater Horn of Africa is prone to extreme climatic conditions, thus, making climate services increasingly important in supporting decision-making processes across a range of climate sensitive sectors. This study aims to provide a comprehensive review of the recent advances, gaps and challenges in the provision of climate services over the region, for each of the components of the Global Framework for Climate Services. The study explores various milestones that have been achieved toward climate service delivery. The achievements include improvement of station network coverage, and enhancing the capacity of member states to utilize various tools in data analysis and generate routine climate products. The advancement in science, and availability of High-Performance Computing has made it possible for forecast information to be provided from nowcasting to seasonal timescales. Moreover, operationalizing of the objective forecasting method for monthly and seasonal forecasts has made it possible to translate tercile forecasts for applications models. Additionally, innovative approaches to user engagement through co-production, communication channels, user-friendly interfaces, and dissemination of climate information have also been developed. Despite the significant progress that has been made in the provision of climate services, there are still many challenges and gaps that need to be overcome in order to ensure that these services are effectively meeting the needs of users. The research of the science underpinning climate variability, capacity building and stakeholder engagement, as well as improved data management and quality control processes are some of the gaps that exist over the region. Additionally, communication and dissemination of climate information, including timely warnings and risk communication, require improvement to reach diverse user groups effectively. Addressing these challenges will require strengthened partnerships, increased investment in capacity building, enhanced collaboration between the climate information producers and stakeholders, and the development of user-friendly climate products. Bridging these gaps will foster greater resilience to climate-related hazards and disasters in the Greater Horn of Africa and support sustainable development in the region