Community-level management of bio-resources for augmenting income from coconut-based farming systems in Kerala state, India

On-farm management of farm residues for mass multiplication of beneficial microbes plays an important role in organic farming as well as integrated nutrient management by improving soil health. Community-level production of organic inputs from crop residues can be a potential source of income for farmers’ groups also. A large scale operational research on community-based bio-resource management, along with soil test based nutrient management, was undertaken by ICAR-CPCRI with financial support from NABARD in the major organic tract of Kerala in the coastal belt - Kanjikuzhy block during 2014-2016. The bio-resource management components under technology integration included farm-level production of organics from crop residues, enrichment using bio-agents, utilization of enriched organics for soil and plant health management and production of bio-primed planting materials. For enhancing the efficiency of Trichoderma-enriched organic manure, two ideal media viz., coir pith compost + neem cake (4:1) and coir pith compost + neem cake + poultry manure + cow dung (2:1:1:1) were standardized. Coconut seedlings produced through bio-priming with Trichoderma sp. showed early germination (90%), higher recovery percentage (79.5%), higher collar girth (17 cm), more number of fronds (9) and height (160 cm). Farm-based participatory action management integrating cost-effective bio-resource management interventions in coconut-based farming systems resulted in improvements in income from coconut by 26 per cent and intercrops by 142.9 per cent, contributing to an increase in the average farm income by 149.8 per cent. The average knowledge index of the respondents related to bio-resource management increased by 115.8 per cent and that of integrated nutrient management by 74.5 per cent

ANTIBIOTICS NANOSUSPENSION: A REVIEW

Nanosuspensions are colloidal dispersions and biphasic system consisting of drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1μm in size. Many drugs including antibiotics are having poor solubility. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving bioavailability of such drugs with low solubility. This review describes the methods of pharmaceutical nanosuspension of antibiotic formulations and pharmaceutical applications in drug delivery. Keywords: Nanosuspension, Bioavailability, Solubilit

Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be life-threatening. Objectives: The study was conducted to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal(GI) risk factors of orthopedic adult inpatient.Materials and methods: A prospective observational NSAIDs induced GI risk related study was conducted over a period of 6 months by clinical pharmacist. Study cohort included 105 orthopaedic inpatients who are taking or will be taking NSAIDs for more than a week. A self-administered questionnaire was completed by each patient. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients‟ risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings.Results: The study groups were stratified into four risk groups according to GI SCORE tool, 27.6% of the patients belonged to high risk or very high risk groups for GI complications. Analysis of prescription pattern revealed that 11.4% of the patients aged over 65 yr, 19% with co morbid disease were prescribed with COX-2 selective inhibitor. Conclusion: In this study assessment of prescription pattern and GI risk factors for NSAIDs were evaluated and in conclusion, physician‟s considerate prescription of NSAIDs with well-understanding of each patient‟s GI risk factors is strongly encouraged to prevent serious GI complication

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

On the Categories of Weak and Strong LM-G-Filter Spaces

In this paper, the authors introduce the notion of weak r-level LM-G-filter spaces and strong p-level LM-G-filter spaces and discuss certain properties of these spaces. The study identifies [Formula: see text]-G, the category of weak r-level LM-G-filter spaces as an isomorphism-closed bireflective full subcategory of LM-G, the category of LM-G-filter spaces. It is also proved that [Formula: see text]-G, the category of strong p-level LM-G-filter spaces is an isomorphism-closed bicoreflective full subcategory of LM-G. Moreover, level decompositions of LM-G-filter spaces are studied and some properties of the associated L-pre G-filter spaces are obtained

Subsoil Acidity Amelioration for Improved Soil Productivity

Subsoil is the layer (stratum) of earth immediately below the surface soil (below 20 cm), consisting predominantly of minerals and leached materials such as iron and aluminium compounds. A favourable condition of subsoil is important for improved productivity of deep-rooted crops like maize, sorghum, soybean etc. Any physical, chemical or biological characteristic of the soil located below the seedbed that limits the ability of crops or pasture to access water and nutrients is considered as a constraint to the subsoil. Subsoil acidity characterized by low Ca and high Al at depths below the plough layer, constrains crop productivity all over the world, especially in the highly weathered acid soils of the humid tropics. Yield reduction due to subsoil acidity results from high concentrations of soluble Al, Mn etc. or low plant-available calcium or magnesium in the root zone, inhibiting physiological and biological activities, root development and uptake of nutrients as well as water. Aluminium toxicity in the subsoil is the major growth limiting factor associated with subsoil acidity. Research findings suggest that conventional surface liming has very little effect on subsoil acidity. Therefore, successful amelioration of acidity in the subsoil requires specialised management practices involving application of soluble sources of calcium or magnesium or improving the solubility and downward movement of liming materials by the application of organic amendments like biochar. This paper attempts to analyse the impacts of subsoil acidity on soil productivity and its mitigation strategies

A quantitative study on the impact of educational modules on the awareness of postural ergonomics among the dental clinical trainees of Jouf University: A North Saudi Arabian Cohort

This research aimed to evaluate the difference between self-reported and actual work postures among dental clinical trainees and the effect of health education on their ergonomic postures. Bad postures induce fatigue, musculoskeletal pain, errors, a negative attitude, and job dissatisfaction. It is necessary to evaluate the awareness of posture ergonomics among clinical trainees as the bad postures captured during their learning years transform into habits that could affect future productivity. Hence, a three-level quantitative study was conducted among the dental trainees at Jouf University, Saudi Arabia. The first level comprised a self-reported survey and an observational study to record the working postures of the participants. At the second level, appropriate health education is customized based on the findings observed at the first level. An unannounced observational study was conducted at the third level to assess the impact of ergonomic education on the working postures of the participants. Gender and the academic year level of the participants were the variables considered in the study. The study found that the participants overrated their correct postures (P = 0.005). Fortunately, the final post-ergonomic education observations found a significant improvement in work posture (8.6 vs 12.4), regardless of the variables considered in the study (P = 0.001). The three best correct postures were placing the feet resting on the floor (52.6 vs 92.8 %), using the seat of a dental chair (57.9 vs 89.5 %), and using an upright position of the legs at the thigh-to-leg angle (53.9 % vs 86.2 %). Therefore, the study emphasizes the importance of training in ergonomics and regular, periodic observation to eradicate bad postures before they become a habit among young dentists

Flexural strength of hydrogen plasma-treated polypropylene fiber-reinforced polymethyl methacrylate denture base material

Objectives: The present study aimed to evaluate flexural strength of hydrogen plasma-treated polypropylene fibers-reinforced polymethyl methacrylate (PMMA) polymer composite. Materials and Methods: One control group with no fiber reinforcement and 9 polymer composite test groups with varying fiber weight percentage (2.5, 5, and 10 Wt%) and aspect ratio (3/220, 6/220, and 12 mm/220 μm) were prepared. Flexural strength was measured using Instron. Results: All hydrogen plasma-treated polypropylene fiber-reinforced test groups obtained significantly higher flexural strength characteristics. Among the test groups, 6 mm long fibers reinforced in 10 Wt% showed superior flexural strength. Conclusion: Hydrogen plasma treatment on polypropylene fiber has a significant role in enhancing the adhesion between PMMA polymer matrix and the polypropylene fibers and thereby the flexural strength

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