Colchicinoids from the Seeds of Colchicum umbrosum

A new colchicinoid from the seeds of Colchicum umbrosum (Colchicaceae) has been isolated and identified as 4-hydroxycolchicine (6) together with seven known colchicinoids as colchicine (1), N-deacetyl-N-formylcolchicine (2), colchifoline (3), colchicilline (4), 3-demethylcolchicine (5), demecolcine (7), and colchicoside (8)

Diterpenoid Alkaloids of Aconitum vulparia Rchb.

From the roots of Aconitum vulparia Rchb., collected in Prum (Germany), a new norditerpenoid alkaloid, named alexhumboldtine, has been isolated along with the known norditerpenoid alkaloids lappaconitine, anthranoyllycoctonine, lycoctonine, puberaconitine, ajacine, and septentriodine. The structure of alexhumboldtine was established on the basis of H-1, C-13, DEPT, homonuclear H-1 COSY, NOESY, HSQC, and HMBC NMR studies. From the aerial parts of the plant another norditerpenoid alkaloid, aconorine, has been isolated

Crataegus tanacetifolia : A Medicinal Plant from Turkey

Species of Crataegus are investigated intensively because of their positive activities on cardiovascular system. Our studies on Crataegus tanacetifolia breed which grows naturally on middle-north Anatolia have been continuing since 1999. Our first study which we conducted with leaf extract of this plant was about the investigations of acute and chronic effects of the plant on blood pressure, blood biochemistry and body ion balance of normal animals. In our recent study we investigated blood pressure, serum lipid levels, body weight, coronary artery wall histopathology and kidney functions on experimentally hypertensive animal models. In addition we studied NOS activities in coronary artery and kidney tissue intended for mechanism of influence. After determining an increase on kidney tissue NOS activity, effective mechanism on bioactivities of Crataegus tanacetifolia was investigated intensively. We started our last study which was more detailed research for determination of NOS activity types

Diterpenoid alkaloids from Delphinium albiflorum

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A New Diterpenoid Alkaloid from the Roots of a White-Flowering Aconitum orientale Sample

From the roots of a white-flowering Aconitum orientale Miller sample, collected in Artvin-Savsat, Turkey, a new diterpenoid alkaloid named aconitorientaline (1) was isolated, along with the known diterpenoid alkaloids septentiriodine, lappaconitine, finaconitine, ranaconitine, puberanidine and delstaphinine (Fig.). The structure of 1 was established on the basis of 1H- and 13C-NMR, DEPT, 1H,1H-COSY, NOESY, HSQC, and HMBC studies. All the known compounds were identified by comparison of their 1H- and 13C-NMR data and co-TLC behavior with those of authentic samples

Diterpenoid alkaloids from Consolida oliveriana

From the aerial parts of Consolida oliveriana (DC) Schrod. a new norditerpenoid alkaloid consolidine (2) has been isolated, in addition to the known alkaloids pubescenine (1), gigactonine, and delsoline and the diterpenoid alkaloid ajaconine (4). The structure of alkaloid 2 was established on the basis of its physical and spectroscopic data including detailed NMR studies. A detailed NMR study on ajaconine (4) resulted in the revision of 11 13C chemical shift assignments

Norditerpenoid and diterpenoid alkaloids from the roots of Aconitum nasutum Fisch ex Reichb

Investigation of the alkaloidal constituents of the roots of Aconitum nasutum led to the isolation and identification of a new diterpenoid alkaloid designated as trabzonine (1). Three known norditerpenoid alkaloids, lappaconitine (2), lycoctonine (3) and gigactonine (4), and two known diterpenoid alkaloids pseudokobusine (5) and septatisine (6) were also isolated. The structures of 1 and 5 were established by detailed analyses of 1H and 13C NMR data. The structure and absolute stereochemistry of pseudokobusine (5) was determined by an X-Ray crystal structure determination

Evaluation Of Antioxidant Activity Of Crataegus Species Collected From Different Regions Of Turkey

Crataegus species (Rosaceae), known as "Howthorn" have found special medicinal use for the treatment of mild heart diseases. This work aims to measure the antioxidant capacities of various Crataegus species growing in Turkey. In this study, the flowers and leaves from 52 samples belonging to 17 taxa of 14 Crataegus species naturally growing in Turkey have been investigated for their antioxidant activity/capacity. Four different methods (CUPRAC, FRAP, ABTS/Persulfate and Folin: FCR assays) were used for determination of the antioxidant capacities of the samples. The leaves and the flowers of the plants were studied separately. Samples representing the same species collected from different locations were studied separately. The results have indicated that the samples differing by some minor morphological characteristics exhibit considerably different antioxidant capacities. Among the flower samples, the most effective species was C. x sinaica Boiss. nothosubsp. sinaica and among the leaf samples C. pentagyna Waldst and Kit. ex. Willd. were the most active. Generally, C. monogyna Jacq. samples have exhibited markedly high antioxidant activity. Moreover, the species collected from Bolu district (surrounded by several forests and lakes) have shown significantly high activity regardless of the species differences among the samples.Wo

Norditerpenoid Alkaloids from Delphinium flexuosum Bieb.

Z. Naturforsch. 67c, 541-544 (2012); received November 30, 2011/March 29, 2012 Delphiniflexine, a new norditerpenoid alkaloid, together with the three known norditerpenoid alkaloids methyllycaconitine, ajadine, and acoseptrigenine were isolated from the aerial parts of Delphinium flexuosum. The structure of delphiniflexine was established on the basis of H-1, C-13, DEPT, homonuclear H-1 COSY, NOESY, HSQC, and HMBC NMR studies

Diterpenoid alkaloids from Delphinium davisii

Three new hetisane-type diterpenoid alkaloids, davisinol, 18-benzoyldavisinol, and Davisin have been isolated from Delphinium davisii Munz. and their structures established by detailed spectroscopic studies. Accurate 1H- and 13C-NMR assignments have been made for kobusine, a related hetisane-type alkaloid, and karakoline, a norditerpenoid alkaloid. The known norditerpenoid alkaloids 14-acetylperegrine, 6-deacetylperegrine, and karakoline and the diterpenoid alkaloids hetisine and hetisinone were also isolated