78 research outputs found
Infection kinetics of Covid-19 and containment strategy
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/06/2021
- Field of study
The devastating trail of Covid-19 is characterized by one of the highest mortality-to-infected ratio for a pandemic. Restricted therapeutic and early-stage vaccination still renders social exclusion through lockdown as the key containment mode.To understand the dynamics, we propose PHIRVD, a mechanistic infection propagation model that Machine Learns (Bayesian Markov Chain Monte Carlo) the evolution of six infection stages, namely healthy susceptible (H), predisposed comorbid susceptible (P), infected (I), recovered (R), herd immunized (V) and mortality (D), providing a highly reliable mortality prediction profile for 18 countries at varying stages of lockdown. Training data between 10 February to 29 June 2020, PHIRVD can accurately predict mortality profile up to November 2020, including the second wave kinetics. The model also suggests mortality-to-infection ratio as a more dynamic pandemic descriptor, substituting reproduction number. PHIRVD establishes the importance of early and prolonged but strategic lockdown to contain future relapse, complementing futuristic vaccine impact
Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
- Author
- A Iwobi
- A Mey
- AB Russell
- AG Torres
- AH Li
- AM Simoons-Smit
- Ana S Almeida
- Anna Tomas
- AS Shon
- B Hochhut
- B Wu
- BW Wortham
- C Fevre
- CP Fung
- CP Ponting
- CR Hsu
- D Balestrino
- D Decre
- D Moranta
- DL Baldi
- DR Flower
- E Llobet
- EG Bligh
- F Boyer
- FF Buettner
- H Tsugawa
- HA Choy
- HF Lavender
- HJ Newton
- HL Tang
- I Shibuya
- J Hinnebusch
- J Hytonen
- J Putze
- JH Yoon
- JM Warszawska
- José A Bengoechea
- K Agladze
- K Beiter
- K Kuhle
- K Mizuta
- K Suzuki
- KM Wu
- KM Yeh
- L Frangeul
- L Izquierdo
- Letícia MS Lery
- Lionel Frangeul
- LK Siu
- M Regue
- M Schlame
- M Teplitski
- MA Bachman
- MA Campos
- MA Khan
- MC Wu
- MM Castiblanco-Valencia
- MS Lawlor
- N Nagarajan
- NB Ray
- O Gal-Mor
- P Di Martino
- P Shah
- P Ye
- PF Sarris
- Philippe Sansonetti
- PJ McNamara
- R Conde-Alvarez
- R Mercado-Lubo
- R Podschun
- R Wacharotayankun
- RC Moellering Jr
- RK Aziz
- Régis Tournebize
- S Bialek-Davenet
- S Brisse
- S Brisse
- S Shrivastava
- SA Shelburne 3rd
- SC Lopes
- SC McKean
- SC McKean
- SC Su
- SF Altschul
- SL Murdoch
- ST Miyata
- Suzanne Bialek-Davenet
- Sylvain Brisse
- T Whitworth
- TL Lin
- V Mohan Das
- Valérie Barbe
- Virginie Passet
- X Nassif
- X Nassif
- X Nassif
- Y Keynan
- YL Chen
- Z Ge
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
- Abuajaila A
- Abuattaya AA
- Abubakar AM
- Abueideh A
- Abuhayyeh HA
- Abuhlega MA
- Abukhalaf S
- Abumunshar AA
- Acuna G
- Adams S
- Adamu S
- Adanan MFSBM
- Adawi I
- Adawi S
- Adawy A
- Ade-Ajayi N
- Adegboyega R
- Ademuyiwa A
- Adesanya O
- Adhiwidjaja CF
- Adofo-Ansong N
- Agboola TH
- Agelebe E
- Aguiar AA
- Aguilar FA
- Aguirre-Lopez P
- Agulham MA
- Ahmad H
- Ahmad ZAH
- Ahmed H
- Ahmed MA
- Ajai OT
- Ajao EA
- Ajiboye OS
- Ajrami Y
- Akan ME
- Akhbari M
- Akhter N
- Akova F
- Al Dammagh NM
- Al Hussein S
- Al Massry NA
- Al Quran TM
- Al-Attar HM
- Al-Halbouni L
- Al-Mamun A
- Al-Mayoof AF
- Al-Momani HM
- Al-Mouakeh A
- Al-Rayyes M
- Al-Salhi AA
- Al-Shwaikh SH
- Al-Slaibi I
- Al-Taher RN
- Al-Taher RN
- Al-Tammam H
- Alakaloko F
- Alattas K
- Alberto C
- Albozidi A
- Alcantara E
- Aldirawi MAM
- Alebbini MM
- Alfoghi M
- Algabri HNO
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- Ali H
- Ali KO
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- Alijla S
- Alijla SS
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- Aljaboo H
- Aljadidi WOFS
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- Alkali YS
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- Almada SA
- Almadhoun W
- Almasri M
- Almeida G
- Almengar I
- Almohamady H
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- Almusleh TFH
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- Bernaus M
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- Bibas F
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- bin Abdullah MY
- Bin Amjad M
- bin Bujarimin AS
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- Bin Othman MY
- bin Zahari Z
- bin Zarwawi AZ
- Bischoff C
- Blain OE
- Blanc T
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- Blazquez-Gomez E
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- Bode C
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- Boonthai A
- Borbonet D
- Borges CG
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- Carbajal LF
- Carloni ICS
- Carrasco AL
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- Carrillo I
- Casado FT
- Caseb P
- Casquero V
- Castaneda FDMD
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- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
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- Yamauchi H
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- Yao W-M
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- Yeo BK
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- Yin P
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- Yue L
- Zaazoua M
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- Zaid E
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- Zakharchuk N
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- Zamora Saa JA
- Zang J
- Zanzi D
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- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
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- Zerwas D
- Zhai M
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- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Combined measurement of the Higgs boson mass from the H → γγ and H → ZZ∗ → 4ℓ decay channels with the ATLAS detector using √s = 7, 8, and 13 TeV pp collision data
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi F
- Algren M
- Alhroob M
- Ali B
- Ali HMJ
- Ali S
- Alibocus SW
- Aliev M
- Alimonti G
- Alkakhi W
- Allaire C
- Allbrooke BMM
- Allen JF
- Allendes Flores CA
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
- Amidei D
- Amor Dos Santos SP
- Amos KR
- Ananiev V
- Anastopoulos C
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Anulli F
- Aoki M
- Aoki T
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Appelt C
- Apyan A
- Aranzabal N
- Arbiol Val SJ
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Arnaez O
- Arnold H
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Assahsah J
- Assamagan K
- Astalos R
- Atashi S
- Atkin RJ
- Atkinson M
- ATLAS Collaboration
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Auriol AD
- Austrup VA
- Avolio G
- Axiotis K
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Bachiu A
- Backman F
- Badea A
- Baer TM
- Bagnaia P
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- Togawa M
- Tojo J
- Tokushuku K
- Tokár S
- Toldaiev O
- Tombs R
- Tomoto M
- Tompkins L
- Topolnicki KW
- Torrence E
- Torres H
- Torró Pastor E
- Toscani M
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- Tost M
- Tovey DR
- Traeet A
- Trandafir IS
- Trefzger T
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trischuk DA
- Trocmé B
- Troncon C
- Truong L
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- Tsai F
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- Tsukerman II
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- Valls Ferrer JA
- Van Arneman DR
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- Vermeulen JC
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- Zhang Z
- Zhao H
- Zhao P
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- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zhou N
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- Zhu CG
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- Zhu Y
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2023
- Field of study
A measurement of the mass of the Higgs boson combining the
H
→
Z
Z
∗
→
4
ℓ
and
H
→
γ
γ
decay channels is presented. The result is based on
140
fb
−
1
of proton-proton collision data collected by the ATLAS detector during LHC run 2 at a center-of-mass energy of 13 TeV combined with the run 1 ATLAS mass measurement, performed at center-of-mass energies of 7 and 8 TeV, yielding a Higgs boson mass of
125.11
±
0.09
(
stat
)
±
0.06
(
syst
)
=
125.11
±
0.11
GeV
. This corresponds to a 0.09% precision achieved on this fundamental parameter of the Standard Model of particle physics
Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery from COVID-19
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Gut microbiota and fatigue in rectal cancer patients: a cross-sectional pilot study
- Author
- A Germain
- A Wallis
- A Wang
- AE Frankel
- C Jang
- D Scharlau
- EC Corfield
- GR Norman
- H Lun
- H Zhang
- JD Forbes
- JE Bajic
- JM Shikany
- JR Galloway-Pena
- JR Sheedy
- K Takahashi
- KA Shaw
- KL Stanhope
- KR Jordan
- L Barberini
- L Galland
- LN Saligan
- LR Feng
- M Maes
- MG Langille
- NB Perez
- Q Zhu
- S Jakobsson
- S Kageyama
- S Yachida
- T Tian
- U Masood
- VJ Gonzalez-Mercado
- VJ Gonzalez-Mercado
- VJ Gonzalez-Mercado
- Y Jiang
- Y Touchefeu
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Diastematomyelia and intramedullary epidermoid spinal cord tumor combined with extradural teratoma in an adult
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Morphological and Genetic Variation in Mexican Wild Populations of Tamarixia radiata
- Author
- Alejandro González-Hernández
- Baeza-Nahed U.
- Barr NB
- Chen X
- Chien CC
- Cáceres S
- De León JH
- Flores D
- French JV
- González C
- Hoy MA
- Hoy MA.
- J. Isabel López-Arroyo
- Kenzy I. Peña-Carrillo
- Kondo T
- Lizondo MJ
- Michaud JP.
- Peña-Carrillo KI
- Pluke RWH
- Quilici S.
- Roberto Mercado-Hernández
- Susana Favela-Lara
- Vizcarra-Valdez N
- Waterston JBD.
- Publication venue
- 'Florida Entomological Society'
- Publication date
- Field of study
- …