The evaluation of the effect of vitamin D replacement on the symptoms of carpal tunnel syndrome in patients with low vitamin D levels

Aim: To evaluate the effect of vitamin D replacement on carpal tunnel syndrome (CTS) symptoms and signs in CTS patients with low vitamin D levels. Methods: This study was designed prospective observably. The patient population was admitted to the EMG (electromyography) laboratory in a tertiary hospital’s Physical Medicine and Rehabilitation Department between 1 January and 31 July 2018.  Initially, 55 patients were included in the study. The patients were categorized into two groups as group 1 (<10 ng / ml) and group 2 (10-20 ng / ml) according to the vitamin D levels. A total of 39 patients and 63 wrists, 17 patients in group 1 (28 wrists) and 22 patients in group 2 (35 wrists), were included in the analysis. Results: There was a statistically significant decrease in visual analogue scale and quick arm-shoulder-hand disability score in two groups when compared before treatment. In two groups, there was a significant improvement in grip and pinch strength after treatment.  At the same time, after treatment we showed that there was a statistically significant increase in median nerve sensory amplitude in two groups. The increase in median nerve sensory velocity was significant in group 2 whereas it was not statistically significant between group 1 vs group 2. Conclusions: Vitamin D replacement can improve symptoms, functional status and electrophysiological findings in CTS patients with low vitamin D levels

Mutasyonel yaklaşımlarla farklı enzim kokteylleri üreten bacillus subtilis suşlarının oluşturulması

TEZ4491Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2003.Kaynakça (s. 78-91) var.xı, 97 s. ; 30 cm.

Restless Legs Syndrome with Current Diagnostic Criteria

Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a chronic movement disorder, characterized by an urge to move legs usually accompanied by uncomfortable sensations and sleep disorders. The prevalence of the syndrome ranges from 1% to 15% in the general population, and about 2% during childhood. RLS is the most common movement disorder in pregnancy. However RLS still remains underdiagnosed probably due to lack of accurate information about the disease. Family history is positive in 50-70% of the primary RLS patients. The secondary form of the syndrome is associated with iron deficiency, renal failure, pregnancy, diabetes mellitus and many rheumatologic disorders. Secondary forms generally manifest at older ages and have a rapid progression with a poorer prognosis. The pathophysiology of RLS is focused on the dopaminergic system, reduced central nervous system iron levels and genetic linkages. Diagnosis is based on clinical features and the diagnostic criteria suggested by International RLS Study Group. Secondary causes must be carefully investigated before the treatment. In mild forms of the disease non-pharmacologic therapies might be useful, while in moderate or severe forms of the disease generally pharmacologic therapies such as dopamine agonists, anticonvulsants, opioids and benzodiazepines are required. (Turkish Journal of Osteoporosis 2015;21: 87-95

Plasma Homocysteine Levels in Postmenoposal Osteoporosis and Osteopenia: The Relation With Biochemical Markers of Bone-Turnover - Original Investigation

The present stduy was planned to investigate the relations of bone mineral density and biochemical markers of bone turnover with plasma levels of homocysteine, vitamin B12 and folate in postmenaposal women. The study was performed in 148 osteoporotic and 75 osteopenic postmenopausal patients. Control group included 61 age-matched healthy postmenopausal women with normal bone mineral density. Plasma homocysteine, serum vitamin B12, folate levels, biochemical markers of bone formation and resorption and lomber vertebra (L2-L4) bone mineral density were determined in study groups. In osteoporotic group, plasma homocysteine levels and both serum and urine markers of bone resorption were found to be increased and, vitamin B12 levels which were found to be significantly decreased had a significant correlation with osteocalcin levels. Althought less marked, similar findings were obtained in osteopenic group, as well. In summary, it was concluded that the reduction in vitamin-B12 levels in osteoporotic postmenaposal women may cause negative effects on bone tissue both by increasing bone resorption indirectly through an increment in homocysteine levels and by a reduction in the direct stimulatory effect of vitamin-B12 on osteoblast and may contribute to development of osteoporosis by shifting the balance between bone formation and resorption in favor of the latter. Therefore, it was suggested that determination of plasma homocysteine and vitamin B12 levels and vitamin B12 supplementation in deficient cases might be useful in treatment of osteoporosis. (Osteoporoz Dünyasından 2006; 12 (2): 22-26

Effects of Robotic Rehabilitation on Motor Functions in Children with Cerebral Palsy

Objective:The aim of this study was to investigate the effects of robotic rehabilitation (RR) on spasticity and motor functions of children with varying types and functional levels of cerebral palsy (CP).Materials and Methods:A total of 28 children were evaluated aged 6-16 years, with level 2-4 CP according to the Gross Motor Function Classification System (GMFCS) who were planned to undergo 30 sessions of RR. Motor functions were evaluated before and after RR using the Gross Motor Function scale-66 (GMFS-66) B, C, D and E dimensions, gastrosoleus spasticity with the Modified Ashworth scale (MAS) and a target was defined for each patient with a Goal Attainment scale (GAS). Following the RR treatment, the efficacy was evaluated by grouping the patients according to the GMFCS level and the type of CP.Results:11% of the patients were at level 2, 36% were at level 3, and 54% were at level 4.61% of them were identified as bilateral spastic, 21% unilateral spastic and 14% mixed type. The patients comprised 50% male and 50% female children with a mean age of 10.8±2.7 years. Mean participation in the RR program was 23±9.6 sessions. A statistically significant improvement was determined in the D dimension of the GMFS in the children at level 2 and 3 of GMFCS (p<0.05), and there were no differences in respect of the MAS and GAS (p>0.05). No differences were determined between the type of CP groups in respect of GMFS, MAS and GAS. Conclusion:It was concluded that the application of RR was of benefit for the children with CP at the level 2 and 3 of GMFCS in respect of the development of standing activities

The clinical, functional, and radiological features of hand osteoarthritis: TLAR-osteoarthritis multi-center cohort study

WOS:000815860200001Objectives: This study aims to evaluate the clinical, functional, and radiological features of hand osteoarthritis (OA) and to examine their relationships in different geographic samples of the Turkish population. Patients and methods: Between April 2017 and January 2019, a total of 520 patients (49 males, 471 females; mean age: 63.6 +/- 9.8 years) with hand OA were included in the study from 26 centers across Turkey by the Turkish League Against Rheumatism (TLAR). The demographic characteristics, grip strengths with Jamar dynamometer, duration of hand pain (month), the severity of hand pain (Visual Analog Scale [VAS]), and morning stiffness were evaluated. The functional disability was evaluated with Duruoz Hand Index (DHI). The Kellgren-Lawrence (KL) OA scoring system was used to assess the radiological stage of hand OA. Results: The DHI had significant correlations with VAS-pain (r=0.367, p0.05). The differences between the groups of radiological hand OA grades in terms of age (p=0.007), VAS-pain (p0.05 for all). Conclusion: In our population, the patients with hand OA had pain, functional disability, and weak grip strength. The functional impairment was significantly correlated with the severity of the pain, and the functional status was worse in high radiological hand OA grades