9 research outputs found
A MetaMorpho magyar-angol gĂ©pi fordĂtĂł rendszer igei vonzatkereteit mƱködtetĆ nyelvtan
A Morphologic kft., a Szegedi TudomĂĄnyegyetem Ă©s az MTA NyelvtudomĂĄnyi IntĂ©zete ĂĄltal közösen fejlesztett magyar-angol gĂ©pi fordĂtĂł rendszer nyelvtanĂĄnak az igei vonzatkeretek kezelĂ©sĂ©t vĂ©gzĆ rĂ©szĂ©t mutatjuk be. A magyar nyelv a környezetfĂŒggetlen nyelvtanok szĂĄmĂĄra ĂĄltalĂĄban nehezen kezelhetĆnek tartott jelensĂ©gek többsĂ©gĂ©t mutatja, ilyenek a szabad szĂłrend, a megszakĂtott összetevĆk, vagy az ĂŒres kategĂłriĂĄk. A vonzatkeretek azonosĂtĂĄsĂĄhoz ezekkel a problĂ©mĂĄkkal mindenkĂ©ppen meg kell birkĂłzni. A MorphoLogic MetaMorpho rendszerĂ©nek kĂŒlönleges eszközeivel, Ă©s az alkalmazott kiterjesztett argumentum modell segĂtsĂ©gĂ©vel mindezen problĂ©mĂĄkra megoldĂĄst kĂnĂĄlunk
Debrecen-Kismacs Ă©s Debrecen-LĂĄtĂłkĂ©p mĂ©rĆĂĄllomĂĄs talajnedvessĂ©g adatsorainak elemzĂ©se
AZ ERDĂSZETI KĂRTEVĆ ARMILLARIA (TUSKĂGOMBA) NEMZETSĂG PATOLĂGIĂJA ĂS A BIOLĂGIAI VĂDEKEZĂS LEHETĆSĂGEI
AZ ERDĂSZETI KĂRTEVĆ ARMILLARIA (TUSKĂGOMBA) NEMZETSĂG PATOLĂGIĂJA ĂS A BIOLĂGIAI VĂDEKEZĂS LEHETĆSĂGEI
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of α(1)-antiproteinase by mercaptoethylguanidine
1. Peroxynitrite is a cytotoxic species that can be formed, among other mechanisms, by the rapid reaction of superoxide with nitric oxide. Peroxynitrite formation has been implicated in a wide range of neurodegenerative and chronic inflammatory diseases, as has the formation of hypochlorous acid by myeloperoxidase. 2. There is considerable interest in the development of peroxynitrite scavengers as therapeutic agents. The thiol compound mercaptoethylguanidine has been suggested to fulfil this role since it has recently been shown to be not only a potent inhibitor of inducible nitric oxide synthase but also a scavenger of peroxynitrite. Indeed, it has been shown to be protective in some experimental models of circulatory shock and inflammation at plasma levels in the approximate range 100â300âÎŒM. 3. One protein inactivated by peroxynitrite is the major inhibitor of serine proteinases in human body fluids, α(1)-antiproteinase. At high (250â1000âÎŒM) concentrations, mercaptoethylguanidine was found to be effective in preventing peroxynitrite-mediated tyrosine nitration and α(1)-AP inactivation. 4. By contrast, lower concentrations of mercaptoethylguanidine (1â60âÎŒM) enhanced the inactivation of α(1)-antiproteinase by peroxynitrite. 5. At all concentrations tested (1â1000âÎŒM), mercaptoethylguanidine decreased the inactivation of α(1)-antiproteinase by hypochlorous acid. 6. We suggest that products of reaction of mercaptoethylguanidine with peroxynitrite or peroxynitrite-derived products could cause damage to α(1)-antiproteinase, and possibly other proteins in vivo, whereas scavenging of hypochlorous acid by mercaptoethylguanidine could contribute to its anti-inflammatory action in vivo