Microwave-Assisted Synthesis of Some 1H-1,2,4-Triazol-3-one Derivatives

4-Amino-5-(methyl/ethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene- 3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared.KEYWORDS Triazole, oxadiazole, hydrazine hydrate, microwave irradiation

Winter Time Concentrations and Size Distribution of Bioaerosols in Different Residential Settings in the UK

The total concentration and size distribution of bioaerosols in three different types of housing (single room in shared accommodation [type I], single bedroom flat in three-storey building [type II] and two- or threebedroom detached houses [type III]) was assessed during the winter. This research was an extension of a previous study carried out in the summer. The measurement campaign was undertaken in winter 2008 and 30 houses were sampled. Samples were taken from kitchens, living rooms, corridors (only in housing type I) and outdoors with an Anderson 6 stage viable impactor. In housing type I, the total geometric mean concentration was highest in the corridor for both bacteria and fungi (3,171 and 1,281 CFU/m3, respectively). In type II residences, both culturable bacteria and fungi were greatest in the living rooms (3,487 and 833 CFU/m3, respectively). The living rooms in type III residences had largest number of culturable bacteria (1,361 CFU/m3) while fungi were highest in kitchens (280 CFU/m3). The concentrations of culturable bacteria and fungi were greater in mouldy houses than non-mouldy houses. A considerable variation was seen in the size distribution of culturable bacteria in type I residences compared to types II and III. For all housing types more than half of culturable bacterial and fungal aerosol were respirable (<4.7 μm) and so have the potential to penetrate into lower respiratory system. Considerable variation in concentration and size distribution within different housing types in the same geographical region highlights the impact of differences in design, construction, use and management of residential built environment on bioaerosols levels and consequent varied risk of population exposure to airborne biological agents. © Springer Science+Business Media B.V. 2012

Microwave Assisted Synthesis and Anti-Lipase Activity of Some New Fluorine-Containing Benzimidazoles

WOS: 000347712200007PubMed: 24696424In this study, a new series of fluorine containing benzimidazoles (4a-l) and bisbenzimidazoles (6a-c, 8) were synthesized by the reaction of o-phenylenediamines with iminoester hydrochlorides (3a-l, 7) in methanol under microwave irradiation. the structures of these newly synthesized compounds were identified by IR, H-1-NMR, C-13-NMR, mass spectroscopy and elemental analysis data. the synthesized compounds were screened for their pancreatic lipase activities. Our results indicate that the compounds 6a, 6b and 6c can serve as an anti-lipase agent. the compounds 6b and 6c inhibited pancreatic lipase activity by 84.03% and 97.49% at a concentration of 3 mu g/mL, respectively

Determination of the protonation constants of triazole derivatives in non-aqueous solvents

Different 17 triazole derivatives were titrated with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, rert-butyl alcohol, N,N-dimethylformamide and acetonitrile), using Potentiometric method. The half neutralization potential values and the corresponding pKa values were determined for all cases

Microwave-assisted synthesis and antifungal activity of some new 1H-1,2,4-triazole derivatives

Ozil, Musa/0000-0002-1980-1364WOS: 000262537600017A number of 3-aryl-4-arylmethylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized by reaction of the corresponding aromatic aldehydes with 4-amino-3-aryl-1H-1,2,4-triazol-5-ones in anhydrous ethanol under microwave irradiation. The newly synthesized 1H-1,2,4-triazole derivatives were tested for antimicrobial activity. They showed no antibacterial activity but slight mycostatic activity against some Candida species

Crystal Structure of 4-[(4-Ethyl-5-Phenyl-4H-1,2,4-Triazol-3-yl)Sulfanyl]Phthalonitrile

Vazquez-Lopez, Ezequiel M./0000-0002-6012-0931; AKCAY, Hakki Turker/0000-0002-8502-9608WOS: 000451645700027The structure of the 4-[(4-ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]phthalonitrile titled molecule is determined by means of X-ray diffraction. the title compound has weak inter- and intramolecular C-H...N-type hydrogen bonds. Furthermore, there is a - interaction between triazole and phenyl rings.Recep Tayyip Erdogan UniversityRecep Tayyip Erdogan University [2014.101.16.01]This study was supported by Recep Tayyip Erdogan University - Research Funding - (Project no 2014.101.16.01)

Mechanical Property Comparison of Al11Si Wheels Grain Refined by Ti, Nb and MTS

In this work, 25 wheels were cast with three different grain refiners: Al5Ti1B, Al3Nb1B and MTS 1582. Samples were machined from the wheels to check the mechanical properties. It was found that Nb grain refinement had the lowest grain size (260 mm) and highest tensile properties (yield strength of 119-124 MPa and ultimate tensile strength of 190-209 MPa). Al5Ti1B and MTS 1582 revealed quite similar results (110 MPa yield and 198 MPa ultimate tensile strength). The fading of the grain refining effect of Al5TiB1 master alloy was observed in both Nb and Ti added castings whereas during the investigated time interval, the fading was not observed when MTS 1582 was used