Klonale Verwandtschaft von Hodgkin-Lymphomen und deren Rezidiven

Zusammenfassung: In dieser Studie untersuchten wir, ob es sich bei Rezidiven von klassischen Hodgkin-Lymphomen (HL) um Rezidive im engeren Sinn oder aber um klonal unverwandte Sekundärtumoren handelt. Die Untersuchungen erfolgten an formalinfixierten, paraffineingebetteten Gewebeproben von 11Patienten. Hodgkin- bzw. Sternberg-Reed-Riesenzellen wurden nach immunhistochemischer Markierung mit CD30 mittels Laser mikrodisseziert und die Fragmentlängen des Schwerkettenimmunglobulin-Gens (IgH) unter Verwendung von FR3- und J-Konsensusprimern analysiert. Zwei Frührezidive nach einer HL-Erstdiagnose zeigten klonale Verwandschaft zu den Primärtumoren, während 3 von 4Frührezidiven nach einem Erst- oder Zweitrezidiv nicht mit dem vorangegangenen HL verwandt waren. Drei Spätrezidive waren mit dem ursprünglichen HL klonal unverwandt. Wir schließen daraus, dass es sich bei so genannten "Rezidiven" von HL z.T. um klonal unverwandte Zweitneoplasien handeln kann, was möglicherweise von therapeutischer Relevanz sein könnt

Micro-Hall Magnetometry Studies of Thermally Assisted and Pure Quantum Tunneling in Single Molecule Magnet Mn12-Acetate

We have studied the crossover between thermally assisted and pure quantum tunneling in single crystals of high spin (S=10) uniaxial single molecule magnet Mn12-acetate using micro-Hall effect magnetometry. Magnetic hysteresis experiments have been used toinvestigate the energy levels that determine the magnetization reversal as a function of magnetic field and temperature. These experiments demonstrate that the crossover occurs in a narrow (~0.1 K) or broad (~1 K) temperature interval depending on the magnitude and direction of the applied field. For low external fields applied parallel to the easy axis, the energy levels that dominate the tunneling shift abruptly with temperature. In the presence of a transverse field and/or large longitudinal field these energy levels change with temperature more gradually. A comparison of our experimental results with model calculations of this crossover suggest that there are additional mechanisms that enhance the tunneling rate of low lying energy levels and broaden the crossover for small transverse fields.Comment: 5 pages, 5 figure

The dynamics of entrepreneurial ecosystems: an empirical investigation

The purpose of this paper is to examine the longitudinal dynamics within entrepreneurial ecosystems. We empirically test how entrepreneurial activities affect intrapreneurial activities within entrepreneurial ecosystems, and vice versa, analyzing twenty-two entrepreneurial ecosystems in Germany from 1993 to 2016. Our analyses reveal that transitions occur among entrepreneurs and intrapreneurs through the different phases of an ecosystem's lifecycle. Our findings provide empirical evidence over time on the evolutionary dynamics of entrepreneurial ecosystems, demonstrating that an increase in entrepreneurial activities leads to a decrease in intrapreneurial activities, and vice versa. Our study offers guidance for policymakers on how to consider fluctuating entrepreneurial and intrapreneurial activities over time and builds the basis for future empirical studies to further advance our understanding of the dynamics of entrepreneurial ecosystems

Performativity, fabrication and trust: exploring computer-mediated moderation

Based on research conducted in an English secondary school, this paper explores computer mediated moderation as a performative tool. The Module Assessment Meeting (MAM) was the moderation approach under investigation. I mobilise ethnographic data generated by a key informant, and triangulated with that from other actors in the setting, in order to examine some of the meanings underpinning moderation within a performative environment. Drawing on the work of Ball (2003), Lyotard (1979) and Foucault (1977, 1979), I argue that in this particular case performativity has become entrenched in teachers’ day-to-day practices, and not only affects those practices but also teachers’ sense of self. I suggest that MAM represented performative and fabricated conditions and (re)defined what the key participant experienced as a vital constituent of her educational identities - trust. From examining the case in point, I hope to have illustrated for those interested in teachers’ work some of the implications of the interface between technology and performativity

An Aeroacoustic Investigation of a Tiltwing eVTOL Concept Aircraft

With the advancement in electric battery design, aircraft designers and manufacturers are no longer constrained to established configurations. Developments in Vertical Take-off and Landing (VTOL) aircraft have also been seen in recent times through the design of modern tiltrotor aircraft such as the AW609 and the V-280 Valor. The combination of these developments allowed engineers to propose designs which utilise the vertical take-off and landing capabilities of a tiltrotor aircraft with electrically driven propulsion systems, deemed eVTOL (Electrically driven Vertical Take-off and Landing). This investigation aims to develop an understanding of the aeroacoustic emissions associated with an eVTOL aircraft, due to acoustics being one of the key components in future certification. The study will consist of an investigation into the baseline design, followed by an optimisation study aiming to reduce the amount of noise generated

Adalimumab improves health-related quality of life in patients with moderate to severe plaque psoriasis compared with the United States general population norms: Results from a randomized, controlled Phase III study

<p>Abstract</p> <p>Objective</p> <p>To evaluate the impact of adalimumab on health-related quality of life (HRQOL) for patients with moderate to severe plaque psoriasis.</p> <p>Background</p> <p>Psoriasis is a chronic, inflammatory, immune-mediated disease that has a significant impact on patients' HRQOL. Adalimumab is a fully human monoclonal antibody that blocks tumor necrosis factor, a pro-inflammatory cytokine, and is effective and well-tolerated for patients with moderate to severe psoriasis.</p> <p>Methods</p> <p>Data were obtained for a secondary analysis of patients in a randomized, controlled Phase III trial evaluating the effect of adalimumab in patients with psoriasis (N = 1,205). Patients with moderate to severe psoriasis were randomized in a 2:1 ratio to adalimumab 80 mg (two 40 mg injections administered subcutaneously at baseline followed by one 40 mg injection every other week from Week 1 to Week 15) or placebo. Short Form-36 (SF-36) Health Survey scores of psoriasis patients were used to assess HRQOL and were compared with United States (US) population norms at baseline and Week 16.</p> <p>Results</p> <p>Baseline Physical Component Summary (PCS) scores for the placebo and adalimumab groups were similar to the general US population. Baseline mean Mental Component Summary (MCS) scores were significantly lower for the adalimumab and placebo groups compared with the general population (47.4, 47.7, and 50.8 points, respectively; p < 0.0001). PCS scores at Week 16 for patients receiving adalimumab had improved and were significantly greater than scores for the general US population (52.7 vs 48.9; p < 0.001). Compared with the general US population, MCS scores at Week 16 were similar for patients receiving adalimumab (51.2 vs 50.8; p = 1.000) and lower for patients receiving placebo (50.8 vs 48.7; p < 0.0001).</p> <p>Conclusion</p> <p>Psoriasis has a broad impact on patient functioning and well-being. Improvement in skin lesions and joint symptoms associated with adalimumab treatment was accompanied by improvements in HRQOL to levels that were similar to or greater than those of the general US population.</p> <p>Trial registration</p> <p>Clinicaltrials.gov NCT00237887</p

PSAP-Expression in einem primären präsakralen neuroendokrinen Tumor: Verwechslungsmöglichkeit mit einem Prostatakarzinom

Zusammenfassung: Primäre präsakrale neuroendokrine Tumoren sind eine seltene Entität mit weniger als 30 beschriebenen Fällen in der Literatur. Wir berichten hier über einen autoptisch diagnostizierten präsakralen neuroendokrinen Tumor, der aufgrund seiner Lokalisation, Morphologie und immunhistochemischen Positivität für prostataspezifische saure Phosphatase (PSAP) zu Lebzeiten des Patienten als metastasiertes Prostatakarzinom fehldiagnostiziert wurde. Dies ist der erste Fallbericht, der eine Expression von PSAP und des Somatostatinrezeptors in dieser Entität dokumentiert