Lexical Similarities and Differences in the Mathematics, Science and English Language Textbooks

The teaching of Science and Math in English in Malaysia is an area of great concern to educators and students alike. This study looks, in particular, at the common word classes among keywords identified in the Science, Math and English language Form One textbooks used in Malaysia and the differences in language use identified in the Science and Math textbooks

The Mediating Role of Contentment Experience: Influence of Job Embeddedness on Mattering and Employee Sustainable Performance

Purpose: The objective of our research is to examine the effects of job embeddedness on contentment experience, anti-mattering, and employee sustainable performance. The study also tested the impact of contentment experience and anti-mattering on the outcome variable i.e., employee sustainable performance.   Theoretical framework: The results of this study indicate that job embeddedness has a positive effect on employee sustainable performance. Contentment experience has a positive effect on employee sustainable performance, but it has a negative effect on mattering. Mattering has a negative effect on employee sustainable performance.   Design/methodology/approach: This research will be conducted using a quantitative, cross-sectional survey design. Data were collected using online surveys administered to a sample of employees from various IT industries. Questionnaires were distributed to 302 employees in various IT sectors in and around Tamilnadu. There are two Mediator’s hypotheses were estimated using process macro using the Andrew Hayes model.   Findings: The findings indicate that job embeddedness has a positive effect on employee performance, and that contentment experience and mattering have a significant impact on employee sustainable performance.   Research, Practical & Social Implication: It provides the necessary understanding of how job embeddedness is related to employee sustainability performance and how to create an environment that fosters employee contentment, thereby leading to better performance. The findings of this research can be used to create a work environment that is conducive to employee sustainability performance.   Originality/value: The study is the first to examine the impact of contentment experience and mattering on employee sustainable performance. Additionally, the study tested the effect of contentment experience on mattering

Lack of Interaction Between the Peptidomimetic Substrates Captopril and Cephradine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97250/1/0091270008329554.pd

Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data

Efficacy of tofacitinib for the treatment of psoriatic arthritis: pooled analysis of two phase 3 studies

Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed the efficacy of tofacitinib using pooled data from two phase 3 studies of patients with active PsA.Data were pooled from OPAL Broaden (NCT01877668) and OPAL Beyond (NCT01882439). Patients had active PsA and either an inadequate response (IR) to ae 1 conventional synthetic disease-modifying antirheumatic drug (csDMARD) and were tumor necrosis factor inhibitor (TNFi)-na < ve (OPAL Broaden), or had IR to ae 1 TNFi (OPAL Beyond). Pooled data included tofacitinib 5 or 10 mg twice daily (BID; to month 6) and placebo (to month 3; patients then switched to tofacitinib 5 or 10 mg BID). Patients also received one background csDMARD. Endpoints included American College of Rheumatology (ACR)20 response and change from baseline in Health Assessment Questionnaire-Disability Index (HAQ-DI) at month 3 (primary endpoints), ACR50/70 response, HAQ-DI response (decrease from baseline ae 0.35) and improvements in painful and swollen joint counts, psoriasis, enthesitis and dactylitis to month 6.A total of 710 patients were included (tofacitinib 5 mg BID: 238; tofacitinib 10 mg BID: 236; placebo: 236). Primary endpoints showed significant improvements at month 3 in patients receiving tofacitinib 5 or 10 mg BID vs. placebo. Significant improvements in HAQ-DI response, painful and swollen joints, psoriasis, enthesitis and dactylitis vs. placebo were observed for both tofacitinib doses at month 3. Efficacy was maintained to month 6 (final pooled time point).In a pooled analysis of csDMARD-IR/TNFi-na < ve and TNFi-IR patients, tofacitinib was superior to placebo at month 3 across four PsA domains: peripheral arthritis, psoriasis, enthesitis and dactylitis.OPAL Broaden (NCT01877668); OPAL Beyond (NCT01882439).Pfizer Inc

Spoligotype Diversity of Mycobacterium tuberculosis over Two Decades from Tiruvallur, South India

Geographically, most tuberculosis (TB) cases in 2018 were reported from India. This TB burden is compounded by MDR-TB and XDR-TB. The strategies for the management and control of TB in the community depend on an understanding of the mode of spread of the different strains of TB isolates in the community. To determine the distribution and trends of M. tb strains over the time period in the community due to treatment, we carried out the present study on changes over two decades. Design/Methods. A total of 1218  M. tb isolates (year: 2001–2018) from Tiruvallur, India, were genotyped by spoligotyping after DNA extraction and subjected to anti-TB drug susceptibility testing for the first-line anti-TB drugs. Results. On analysis with the SpolDB4 database, majority (2001–2003: 53.32% and 2015–2018: 46.3%) of the isolates belonged to East African Indian (EAI) lineage, and the orphans designated in comparison to SpolDB4 stood 33% among 2001–2003 strain collection and 46.3% among 2015–2018 strain collection. 10.2% (2001–2003) and 9.26% (2015 to 2018) of isolates were monoresistant to isoniazid (H). MDR strains were less common among EAI strains (3.2%) compared to non-EAI strains (10.32%). Conclusions. EAI is the most predominant lineage in Tiruvallur, despite the presence of highly transmissible lineages like Beijing for the last two decades. The prevalence of MDR-TB is below the national average of 2-3% among the new TB cases in the last two decades. The reason can be attributed to the well-established nature of the locally circulating strains in this region which are not associated with drug resistance