Formal descriptions of material manipulations: an exploration with cuts and shadows

Shape computation in design is never purely limited to visual aspects and ideally includes material aspects as well. The physicality of designing introduces a wide range of variables for designers to tackle within the design process. We present a simple design exercise realised in four stages where we physically manipulate perforated cardboard sheets as a case to make material variables explicit in the computation. The emphasis is on representing sensory aspects rather than easily quantifiable properties more suitable for simulations. Our explorations demonstrate the use of visual rules to represent actions, variables and form as well as how to control the variables to create new results, both desired and surprising, in materially informed ways

Finite element modelling in integral design strategies of form- and bending-active hybrid structures

This paper discusses form-finding and simulation strategies for form- and bending-active hybrid structures, with practical feedback from two realised projects. Next to some general aspects of computational form-finding approaches with focus on finite element methods (FEM), the influence of changing mechanical properties of elastic beams on the resultant form-found hybrid system will be discussed on an umbrella structure with integrated bendingactive beam elements. Alongside the question of simulation strategies comes the search for a practical design setup to establish an FEM environment that is cross integrating information from various other modelling environments. This is discussed through the case study project M1 where physical form-finding and vector-based spring methods are utilised to generate input data for the FEM simulation

Optical parameters of leaves of seven weed species

The absorption coefficient (k), infinite reflectance (R), and scattering coefficient (s) were tabulated for five wavelengths and analyzed for statistical differences for seven weed species. The wavelengths were: 0.55-micrometer, 0.65-micrometers, 0.85-micrometer, 1.65-micrometers, and 2.20-micrometer. The R of common lambsquarters (Chenopodium album L.), Johnsongrass (Sorghum halepense (L.) Pers.), and annual sowthistle (Sonchus oleraceus L.) leaves at the 0.85-micrometer wavelength were significantly (p=0.05) higher than for sunflower (Heliantus annus L.), ragweed parthenium (Parthenium hysterophorus L.), or London rocket (Sisymbrium irio L.). Annual sowthistle had the largest k value, and Plamer amaranth (Amaranthus palmer S. Wats.) had the smallest k value at the 0.65 approximately chlorophyll absorption wavelength. In general, john-songress, ragweed parthenium, or London rocket had the largest s values among the five wavelengths, wereas annual sowthistle and plamar amaranth were usually lowest

When Job Performance is All Relative: How Family Motivation Energizes Effort and Compensates for Intrinsic Motivation

This is the author accepted manuscript. The final version is available from Academy of Management via the DOI in this record.Supporting one’s family is a major reason why many people work, yet surprisingly little research has examined the implications of family motivation. Drawing on theories of prosocial motivation and action identification, we propose that family motivation increases job performance by enhancing energy and reducing stress, and it is especially important when intrinsic motivation is lacking. Survey and diary data collected across multiple time points in a Mexican maquiladora generally support our model. Specifically, we find that family motivation enhances job performance when intrinsic motivation is low—in part by providing energy, but not by reducing stress. We conclude that supporting a family provides a powerful source of motivation that can boost performance in the workplace, offering meaningful implications for research on motivation and the dynamics of work and family engagement

Kinetics of Palladium(0)‐Allyl Interactions in the Tsuji‐Trost Reaction, derived from Single‐Molecule Fluorescence Microscopy

Single‐molecule (SM) chemistry is devoted to unravel reaction steps which are hidden in cuvette experiments. Controversies about the substrate activation during the Tsuji‐Trost deallylation motivated us to study, on the single‐molecule level, the kinetics of the catalyst precursor Pd(PPh3)4 with our recently designed two‐color fluorescent probes. Photochemical, metal‐free bypass reactions were found and taken into account by the combination of spectrally separated single‐molecule TIRF‐microscopy and state‐of‐the art analysis procedures. Unselective π‐complex formation (KD≈103 M−1) precedes the insertion of the active catalyst into the C−OR bond (RO−=leaving group), indicated by the lacking immediate change of fluorescence color. The formed intermediate then decomposes on a time scale of≥2 – 3 s to the deallylated product

Evaluation Of Dye-micelle Binding Constants Using Diffusion Sensitive Band Broadening Effects

The diffusion coefficients of small solutes can be significantly altered by the presence of association colloids such as micelles. A relationship is utilized that relates the diffusion coefficient of a solute to its partitioning or binding behavior to a micellar pseudo phase. The Taylor-Aris dispersion method was used to evaluate the diffusion coefficient of several dyes in the presence and absence of sodium dodecyl sulfate micelles. With this approach, all binding constants can be determined easily and reproducibly. The theory, experimental approach, and advantages of this technique are discussed. © 1988

Patient Preference Studies for Advanced Prostate Cancer Treatment Along the Medical Product Life Cycle: Systematic Literature Review

Background: Patient preference studies can inform decision-making across all stages of the medical product life cycle (MPLC). The treatment landscape for advanced prostate cancer (APC) treatment has substantially changed in recent years. However, the most patient-relevant aspects of APC treatment remain unclear. This systematic review of patient preference studies in APC aimed to summarize the evidence on patient preferences and patient-relevant aspects of APC treatments, and to evaluate the potential contribution of existing studies to decision-making within the respective stages of the MPLC. Methods: We searched MEDLINE and EMBASE for studies evaluating patient preferences related to APC treatment up to October 2020. Two reviewers independently performed screening, data extraction and quality assessment in duplicate. We descriptively summarized the findings and analyzed the studies regarding their contribution within the MPLC using an analytical framework. Results: Seven quantitative preference studies were included. One study each was conducted in the marketing approval and the health technology assessment (HTA) and reimbursement stage, and five were conducted in the post-marketing stage of the MPLC. While almost all stated to inform clinical practice, the specific contributions to clinical decision-making remained unclear for almost all studies. Evaluated attributes related to benefits, harms, and other treatment-related aspects and their relative importance varied relevantly between studies. All studies were judged of high quality overall, but some methodological issues regarding sample selection and the definition of patient-relevant treatment attributes were identified. Conclusion: The most patient-relevant aspects regarding the benefits and harms of APC treatment are not yet established, and it remains unclear which APC treatments are preferred by patients. Findings from this study highlight the importance of transparent reporting and discussion of study findings according to their aims and with respect to their stage within the MPLC. Future research may benefit from using the MPLC framework for analyzing or determining the aims and design of patient preference studies. Keywords: benefit-harm assessment; medical product life cycle; patient preferences; patient-centered care; preference research; prostate cancer; systematic revie

Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study

BACKGROUND: Craving for alcohol is a highly controversial subjective construct and may be clarified by Loewenstein's visceral theory, which emphasizes craving's behavioral effects on the relative value of alcohol. Based on the visceral theory, this study examined the effects of a craving induction on the relative value of alcohol as measured by a behavioral choice task. In addition, based on previous evidence of its role in the expression of craving, the influence of DRD4 VNTR genotype (DRD4-L vs. DRD4-S) was also examined. METHODS: Thirty-five heavy drinkers (54% male; 31% DRD4-L) were randomly assigned to receive either a craving induction (exposure to personally relevant alcohol cues) or a control induction (exposure to neutral cues), which was followed by an alcohol-money choice task. Participants were assessed for craving and positive/negative affect throughout the procedure, and relative value of alcohol was derived from participant choices for alcohol versus money. DRD4 VNTR status was assessed retrospectively via buccal samples using previously established protocols. RESULTS: Factorial analysis of the craving induction revealed that it was associated with significant increase in craving (p < .001), but not greater relative value of alcohol. Factorial analyses including DRD4 VNTR genotype of did not suggest an influence on reactivity to the craving induction, although this analysis was substantially compromised by small cell sample sizes. Continuous analyses revealed that craving was significantly associated with the relative value of alcohol (p < .05) and possession of the DRD4-L allele further amplified this relationship (p < .001). CONCLUSION: These results are interpreted as generally supporting Loewenstein's visceral theory of craving and evidence of a functional role of DRD4 VNTR genotype in the expression of craving for alcohol. Methodological limitations, mechanisms underlying these findings, and future directions are discussed

Packings of 3D stars: stability and structure

© 2016, Springer-Verlag Berlin Heidelberg.We describe a series of experiments involving the creation of cylindrical packings of star-shaped particles, and an exploration of the stability of these packings. The stars cover a broad range of arm sizes and frictional properties. We carried out three different kinds of experiments, all of which involve columns that are prepared by raining star particles one-by-one into hollow cylinders. As an additional part of the protocol, we sometimes vibrated the column before removing the confining cylinder. We rate stability in terms of r, the ratio of the mass of particles that fall off a pile when it collapsed, to the total particle mass. The first experiment involved the intrinsic stability of the column when the confining cylinder was removed. The second kind of experiment involved adding a uniform load to the top of the column, and then determining the collapse properties. A third experiment involved testing stability to tipping of the piles. We find a stability diagram relating the pile height, h, versus pile diameter, (Formula presented.) , where the stable and unstable regimes are separated by a boundary that is roughly a power-law in h versus (Formula presented.) with an exponent that is less than unity. Increasing vibration and friction, particularly the latter, both tend to stabilize piles, while increasing particle size can destabilize the system under certain conditions