Biocompatible parylene neurocages developing a robust method for live neural network studies

We present a refined method and design for fabricating parylene neurocages for in vitro studies of live neural networks. Parylene neurocages are biocompatible and very robust, making them ideally suited for studying the synaptic connections netween individual neurons to gain insight into learning and memory. The neurocage fabrication process is significantly less complex than earlier versions. Previous neurocage designs achieved limited neuronal outgrowth; however, the long-term cell survival rate was 50%

Development of biocompatible parylene neurocages

We present a refined method and design for building parylene neurocages for in vitro studies of live neural networks. Parylene neurocages are biocompatible and very robust, making them ideally suited for studying the synaptic connections between individual neurons to gain insight into learning and memory. The neurocage fabrication process is significantly less complex than earlier versions. Previous neurocage designs achieved limited neuronal outgrowth; however, the long-term cell survival rate was 50%

Quantum phase transitional patterns in the SD-pair shell model

Patterns of shape-phase transition in the proton-neutron coupled systems are studied within the $SD$-pair shell model. The results show that some transitional patterns in the $SD$-pair shell model are similar to the $U(5)-SU(3)$, $U(5)-SO(6)$ transitions with signatures of the critical point symmetry of the interacting boson model.Comment: 13 pages, 7 figure

The Internationalization of Higher Education in China: A Case Study of A University

This study focuses on analyzing the internationalization of higher education in a specific university in China during the 13th Five Year Plan Period (2016-2020). The purpose of the research is to collect, classify, and sort literature related to the topic and discuss the development context and implementation status of higher education internationalization. The study uses document analysis and case interviews to conduct a case study of the university. In the document analysis, university affairs materials, subordinate school data statistics, and other relevant documents are examined to understand the current practice of education internationalization of the university. The study then proposes a development path for the university's internationalization, which includes talent training, faculty members, scientific research, and people-to-people exchange. Overall, the study provides insights into the internationalization of higher education in a specific university in China and presents a potential pathway for the university to enhance its global engagement

Internationalization of Higher Education in Shaanxi Province, China: Status Quo and Development Trends

This study focuses on the status quo of internationalization of higher education in China, and explores the current situation and development of higher education internationalization in Shaanxi Province. As one of the important cradles of Chinese civilization, Shaanxi, as the starting point of the ancient Silk Road, has embraced a new opportunity for international exchanges and cooperation in the field of education. The level of internationalization is increasing, universities in Shaanxi actively build platforms for international exchanges and cooperation, open various communication channels, and create opportunities for cooperation. However, the platform and system for communication, as well as ideas, policies and measures, need to be further improved. Based on the research content of higher education internationalization, this essay clarifies the specific forms, summarizes the development trends, and puts forward targeted countermeasures according to the actual situation

Bis(2-{[3-methyl-4-(2,2,2-trifluoro­eth­oxy)-2-pyrid­yl]methyl­sulfan­yl}-1H,3H +-benzimidazolium) 2,5-dichloro-3,6-dioxocyclo­hexa-1,4-diene-1,4-diolate

The title salt, 2C16H15F3N3OS+·C6Cl2O4 2−, is composed of two independent cations of a lansoprazole {systematic name 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole} inter­mediate and a dianion of chloranilic acid. In the cations of the lansoprazole inter­mediate, the dihedral angles between the least-squares planes of the pyridine and benzimidazole rings are 11.1 (6) and 13.1 (5)°, respectively. The dihedral angles between the mean plane of the benzene ring in the chloranilic acid dianion and the pryidine and benzimidazole rings of the two lansoprazole inter­mediate groups are 71.8 (1)/80.5 (7) and 74.2 (4)/74.8 (6)°. In addition to ionic bond inter­actions, the lansoprazole inter­mediate and chloranilic ions are connected by strong N—H⋯O hydrogen bonds, which produce a set of extended O—H⋯O—H⋯O—H chains along the b axis in the (011) plane. In addition, weak C—H⋯O, C—H⋯F, N—H⋯Cl and π–π [centroid–centroid distances = 3.5631 (15), 3.8187 (13), 3.7434 (17) and 3.842 (2) Å] inter­molecular inter­actions are observed, which contribute to crystal packing stability

Microbial exposure during early human development primes fetal immune cells

Human fetal immune system begins to develop early during gestation, however factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in-utero and their contribution towards activation of memory T cells in fetal tissues. We profiled microbes across fetal organs using 16S-rRNA gene sequencing and detected low but consistent microbial signal in fetal gut, skin, placenta and lungs, in 2nd trimester of gestation. We identified several live bacterial strains including Staphylococcus and Lactobacillus in fetal tissues, which induced in vitro activation of memory T cells in fetal mesenteric lymph-node, supporting the role of microbial exposure in fetal immune-priming. Finally, using SEM and RNA-ISH, we visualised discrete localisation of bacteria-like structures and eubacterial-RNA within 14th week fetal gut lumen. These findings indicate selective presence of live-microbes in fetal organs during 2nd trimester of gestation and have broader implications towards establishment of immune competency and priming before birt