COLLECTIVE MIGRATION STUDY OF BREAST CANCER CELLS IN 2D

Ph.DDOCTOR OF PHILOSOPH

Vigilancia de la calidad del agua para consumo humano en zonas rurales de la provincia de Moyobamba

The present work entitled "QUALITY WATER MONITORING FOR HUMAN CONSUMPTION IN RURAL AREAS OF THE MOYOBAMBA PROVINCE -2012 ", was developed in the scope of the Moyobamba province, having as aim Evaluate the systems of supply of drinkable water in the rural area of Moyo bamba province. The research type is descriptive, was taken as a sample the major population centers in the district of the province, of which has been assessed both the management and service coverage as well as the sanitary status of the water infrastructure for human consumption. It has been possible to identify those responsible for the management of water services in the evaluated localities, as well as the age, procurement system type, the sources and the type of deposits in each case. Likewise it can be concluded that in general the systems water management supply in the rural areas of the Moyo bamba province, is inefficient since the responsibility in the conduction of this service is not uniform being different levels of responsibility as are the JASS, the Municipality and by means of communal directive. Also, due to the little income by contributions from users, do not have trained operators and the coverage is not the 1 00% of the population. In regard to the health status of the water supply infrastructure, it has been found that in most cases, the system has a antiquity considered and do not have altemative systems of abstraction. As well as the sources come from groundwater without treatment. of conservation. Key words: drinkable water, human consumptionEl presente trabajo titulado "VIGILANCIA DE LA CALIDAD DEL AGUA PARA CONSUMO HUMANO EN ZONAS RURALES DE LA PROVINCIA DE MOYOBAMBA-2012"; se desarrolló en el ámbito de la provincia de Moyobamba, teniendo como objetivo Evaluar los sistemas de abastecimiento de agua potable en el ámbito rural de la provincia de Moyobamba El tipo de investigación es descriptiva, se tomó como muestra los principales centros poblados en el ámbito distrital de la provincia, de los cuales se ha evaluado tanto la gestión y cobertura del servicio así como el estado sanitario de la infraestructura de abastecimiento de agua para consumo humano Se ha logrado identificar los responsables de la administración de los servicios de agua en las localidades evaluadas, así como la antigüedad, tipo de sistema de abastecimiento, las fuentes y el tipo de captaciones en cada caso. Así m1smo se puede concluir que en general la gestión de los sistemas de abastecimiento de agua en las zonas rurales de la provincia de Moyobamba, es ineficiente dado que la responsabilidad en la conducción de este servicio no es uniforme encontrándose diferentes niveles de responsabilidad como son las JASS, La Municipalidad y mediante directiva comunal. Asimismo debido al poco ingreso por aportes de los usuarios, no cuentan con operadores capacitados y la cobertura no es al 1 00 % de la población. En cuanto al Estado Sanitario de la infraestructura de abastecimiento de agua, se ha encontrado que en la mayoría de casos el sistema tiene una antigüedad considerada y no cuentan con sistemas alternos de captación. Así como las fuentes provienen de aguas subterráneas sin tratamiento. En cuanto a la captación, estos no cuentan con cercos de protección y las estructuras están en mal estado de conservación.Tesi

Red Hill Cemetery Project: Creating a Cultural Heritage Database

This age of booming technological advancement has brought a breadth of new opportunities for understanding and documenting history, from digital mapping to database-building capabilities unrivaled in past historical efforts, opportunities which the research team behind the Red Hill Cemetery Project are utilizing in the effort to develop a virtual cemetery. The research team, in cooperation with the Okefenokee Heritage Center and the community of Waycross, seek to develop a scholarly understanding, grounded in consideration of the community and its history, of the oldest African-American cemetery in Waycross, Georgia. The physical cemetery, now overgrown and suffering from decades-long neglect and vandalism, holds an estimated 2000 burials. The team is focused on four projects. First, developing an application for inclusion of the cemetery on the National Register of Historic Places. Second, using innovative photographic and mapping technologies to build an accessible interactive map of the physical conditions of Red Hill Cemetery, the research will culminate in the digital reconstruction of the original cemetery layout. Third, the development of a public biographical database that includes all identifiable individuals buried at Red Hill. Fourth, the team will collect, transcribe, and publish oral histories of the site and the larger Waycross African American Community, aiming to preserve the voices of Waycross before they are irretrievably lost. Website:https://davidsheffler.domains.unf.edu/redhillcemetery

Arginine Methylation of the PGC-1α C‑Terminus Is Temperature- Dependent

We set out to determine whether the C-terminus (amino acids 481–798) of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α, UniProt Q9UBK2), a regulatory metabolic protein involved in mitochondrial biogenesis, and respiration, is an arginine methyltransferase substrate. Arginine methylation by protein arginine methyltransferases (PRMTs) alters protein function and thus contributes to various cellular processes. In addition to confirming methylation of the C-terminus by PRMT1 as described in the literature, we have identified methylation by another member of the PRMT family, PRMT7. We performed in vitro methylation reactions using recombinant mammalian PRMT7 and PRMT1 at 37, 30, 21, 18, and 4 °C. Various fragments of PGC-1α corresponding to the C-terminus were used as substrates, and the methylation reactions were analyzed by fluorography and mass spectrometry to determine the extent of methylation throughout the substrates, the location of the methylated PGC-1α arginine residues, and finally, whether temperature affects the deposition of methyl groups. We also employed two prediction programs, PRmePRed and MePred-RF, to search for putative methyltransferase sites. Methylation reactions show that arginine residues R548 and R753 in PGC-1α are methylated at or below 30 °C by PRMT7, while methylation by PRMT1 was detected at these same residues at 30 °C. Computational approaches yielded additional putative methylarginine sites, indicating that since PGC-1α is an intrinsically disordered protein, additional methylated arginine residues have yet to be experimentally verified. We conclude that temperature affects the extent of arginine methylation, with more methylation by PRMT7 occurring below physiological temperature, uncovering an additional control point for PGC-1α

Eficacia en la extracción de aceite a partir de especies vegetales

Throughout history, essential oils have been extracted from natural sources such as plants for various purposes such as pharmacology, chemistry, and cosmetics. The extraction process involves techniques ranging from essential distillation with steam to more technical ones like supercritical fluids and microwave-assisted hydrodistillation, each with varying yields. Our study analyzed different extraction methods for essential oils through qualitative and quantitative documentary analysis. We also conducted the statistical analysis using the Statgraphics Centurion XVI software. The results show that microwave-assisted hydrodistillation is the most efficient method for extracting essential oils regardless of the plant material used. Other methods did not show significant effects based on our ANOVA analysis with a P-value less than 0.05 and a 95.0% confidence level.A lo largo de la historia, los aceites esenciales se han extraído de fuentes naturales como las plantas para diversas aplicaciones como farmacología, química y cosmética. El proceso de extracción involucra técnicas que van desde la destilación esencial con vapor hasta otras más técnicas como fluidos supercríticos e hidrodestilación asistida por microondas, cada una con rendimientos variables. El estudio analizó diferentes métodos de extracción de aceites esenciales mediante análisis documental cualitativo y cuantitativo. Se realizó el análisis estadístico utilizando el programa Statgraphics Centurion XVI. Los resultados muestran que la hidrodestilación asistida por microondas es el método más eficiente para la extracción de aceites esenciales independientemente del material vegetal utilizado. Otros métodos no mostraron efectos significativos según nuestro análisis ANOVA con un valor-P inferior a 0,05 y un nivel de confianza del 95,0 %

Advances in the Description of the Speech of People with Lip-palatal Fissure

This article compiles information of currentresearch in the speech description of people withcleft lip and palate, in order to present the advancesin the field of clinical phonetics in theformation of the Speech Language Pathologists.This article also explores the case study of a 12years old subject with cleft palate, hypernasalspeech, nasal air escapes and glottal stops, whichwere detected perceptual and spectrographically

Vigilancia de la calidad del agua para consumo humano en zonas rurales de la provincia de Moyobamba

The present work entitled "QUALITY WATER MONITORING FOR HUMAN CONSUMPTION IN RURAL AREAS OF THE MOYOBAMBA PROVINCE -2012 ", was developed in the scope of the Moyobamba province, having as aim Evaluate the systems of supply of drinkable water in the rural area of Moyo bamba province. The research type is descriptive, was taken as a sample the major population centers in the district of the province, of which has been assessed both the management and service coverage as well as the sanitary status of the water infrastructure for human consumption. It has been possible to identify those responsible for the management of water services in the evaluated localities, as well as the age, procurement system type, the sources and the type of deposits in each case. Likewise it can be concluded that in general the systems water management supply in the rural areas of the Moyo bamba province, is inefficient since the responsibility in the conduction of this service is not uniform being different levels of responsibility as are the JASS, the Municipality and by means of communal directive. Also, due to the little income by contributions from users, do not have trained operators and the coverage is not the 1 00% of the population. In regard to the health status of the water supply infrastructure, it has been found that in most cases, the system has a antiquity considered and do not have altemative systems of abstraction. As well as the sources come from groundwater without treatment. of conservation. Key words: drinkable water, human consumptionEl presente trabajo titulado "VIGILANCIA DE LA CALIDAD DEL AGUA PARA CONSUMO HUMANO EN ZONAS RURALES DE LA PROVINCIA DE MOYOBAMBA-2012"; se desarrolló en el ámbito de la provincia de Moyobamba, teniendo como objetivo Evaluar los sistemas de abastecimiento de agua potable en el ámbito rural de la provincia de Moyobamba El tipo de investigación es descriptiva, se tomó como muestra los principales centros poblados en el ámbito distrital de la provincia, de los cuales se ha evaluado tanto la gestión y cobertura del servicio así como el estado sanitario de la infraestructura de abastecimiento de agua para consumo humano Se ha logrado identificar los responsables de la administración de los servicios de agua en las localidades evaluadas, así como la antigüedad, tipo de sistema de abastecimiento, las fuentes y el tipo de captaciones en cada caso. Así m1smo se puede concluir que en general la gestión de los sistemas de abastecimiento de agua en las zonas rurales de la provincia de Moyobamba, es ineficiente dado que la responsabilidad en la conducción de este servicio no es uniforme encontrándose diferentes niveles de responsabilidad como son las JASS, La Municipalidad y mediante directiva comunal. Asimismo debido al poco ingreso por aportes de los usuarios, no cuentan con operadores capacitados y la cobertura no es al 1 00 % de la población. En cuanto al Estado Sanitario de la infraestructura de abastecimiento de agua, se ha encontrado que en la mayoría de casos el sistema tiene una antigüedad considerada y no cuentan con sistemas alternos de captación. Así como las fuentes provienen de aguas subterráneas sin tratamiento. En cuanto a la captación, estos no cuentan con cercos de protección y las estructuras están en mal estado de conservación.Tesi

Conveniencia del uso de ladrillos y argamasa en los procesos de restauración de edificaciones de tipologia colonial en Cartagena De Indias

Tesis (Ingeniero Civil).--Universidad de Cartagena. Facultad de Ciencias E Ingenierías. Programa de Ingeniería Civil, 2016El objetivo de esta investigación busca determinar, a través de un análisis comparativo entre los muros de tipología colonial y muestras de muretes construidos con materiales de fuentes actuales, si estos son convenientes para emplearlos en las restauraciones estructurales de las edificaciones de tipología colonial, con el fin de que estos no pierdan su valor patrimonial