OS FATORES AMBIENTAIS E SUA RELAÇÃO COM O BAIXO PESO AO NASCER NO EXTREMO SUL DO BRASIL

<!-- /* Font Definitions */ @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-1610611985 1107304683 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:PT-BR; mso-fareast-language:PT-BR;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> The study of cases and check-ups performed in Rio Grande county/RS, aimed to evaluate Low Birth Weight (LBW) in newborns of mothers residing near the industrial section in the town, and thought to be exposed to environmental pollution. 547 mothers who gave birth in hospital maternity units were interviewed between April and November 2003. The sample was made up of 138 cases and 409 check-ups. The results show that the location of the mothers residence in the area in question showed a greater odds ratio to LBW both in the bivaried analysis (RO 1.87; IC95 % 0.95-3.66) and the multivaried analysis (RO=4.67; IC95 % 0.95-22.90), but the p values were closer to the established cut off point (p=0.067 and p=0.057, respectively). Thus a relation between exposure to pollutants and LBW is shown, although additional studies are needed to clarify this issue area. These results show that it is important for health care workers, and especially by nurses, to take into account environmental issues regarding planning, development and prenatal care of pregnant women, as well as extended assistance to their children after birth.Esta investigación  de casos y controles, realizada en el municipio de  Rio Grande/RS, tuvo como objetivo evaluar el bajo peso al nacer (BPN) en recién-nacidos de madres que viven en las proximidades del área industrial de esta ciudad, consideradas más expuestas a la polución ambiental. Participaron de la encuesta  547 madres que alumbraron en las maternidades en los meses de abril a noviembre de 2003.  La muestra estuvo compuesta de 138 casos y 409 controles. Los resultados muestran que el lugar de la vivienda materna en el área expuesta presentó razones de odds mayores para BPN tanto en el análisis bivariado (RO 1,87; IC95% 0,95-3,66), cuanto en el análisis multivariado  (RO= 4,67; IC95% 0,95-22,90), pero los valores de p ubicándose mucho cerca del punto de corte establecido  (p=0,067 e p=0,057, respectivamente). De esta forma, se ve que hay una relación entre la exposición a contaminantes y BPN, pero son necesarios otros estudios para poder responder a esta cuestión con más claridad. Esos resultados muestran la necesidad de que la influencia ambiental sea considerada por parte de todo el grupo de salud, y por el enfermero en especial, tanto en lo que se refiere al planeamiento, desarrollo y acompañamiento  pre-natal  de las gestantes, como también, en el seguimiento de la asistencia a sus niños después del nacimiento  Este estudo de casos e controles, realizado no município de Rio Grande/RS, teve como objetivo avaliar o baixo peso ao nascer (BPN) em recém-nascidos de mães residentes nas proximidades da área industrial deste município, consideradas mais expostas à poluição ambiental. Foram entrevistadas 547 mães que deram à luz nas maternidades do município, durante os meses de abril a novembro de 2003. A amostra foi composta por 138 casos e 409 controles. Os resultados mostram que o local da residência materna na área exposta apresentou razões de odds maiores para BPN tanto na análise bivariada (RO 1,87; IC95% 0,95-3,66), quanto na análise multivariada (RO= 4,67; IC95% 0,95-22,90), mas os valores de p situaram-se muito próximos ao ponto de corte estabelecido (p=0,067 e p=0,057, respectivamente). Desta maneira, esboça-se uma relação entre exposição a poluentes e BPN, mas são necessários outros estudos  para poder responder a esta questão com maior clareza. Esses resultados mostram a necessidade de que a influência ambiental seja considerada por parte de toda a equipe de saúde, e pelo enfermeiro em especial, tanto no que se refere ao planejamento, desenvolvimento e acompanhamento pré-natal das gestantes, como também, no seguimento da assistência de suas crianças, após o nascimento. &nbsp

Adaptação do modelo Noah-MP-Crop para representar a cultura da soja em Rondônia, Brasil.

O objetivo deste trabalho foi ajustar e avaliar o modelo Noah-MP-Crop utilizando uma cultivar de soja na região de Rondônia, para simular a cultura durante a safra 2017/2018.CBAGRO 2023

The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells

In approximately 15% of patients with acute myeloid leukemia (AML), total and phosphorylated EGFR proteins have been reported to be increased compared to healthy CD34+ samples. however, it is unclear if this subset of patients would benefit from EGFR signaling pharmacological inhibition. pre-clinical studies on AML cells provided evidence on the pro-differentiation benefits of EGFR inhibitors when combined with ATRA or ATO in vitro. despite the success of ATRA and ATO in the treatment of patients with acute promyelocytic leukemia (APL), therapy-associated resistance is observed in 5-10% of the cases, pointing to a clear need for new therapeutic strategies for those patients. In this context, the functional role of EGFR tyrosine-kinase inhibitors has never been evaluated in APL. here, we investigated the EGFR pathway in primary samples along with functional in vitro and in vivo studies using several APL models. we observed that total and phosphorylated EGFR (Tyr992) was expressed in 28% and 19% of blast cells from APL patients, respectively, but not in healthy CD34+ samples. Interestingly, the expression of the EGF was lower in APL plasma samples than in healthy controls. the EGFR ligand AREG was detected in 29% of APL patients at diagnosis, but not in control samples. In vitro, treatment with the EGFR inhibitor gefitinib (ZD1839) reduced cell proliferation and survival of NB4 (ATRA-sensitive) and NB4-R2 (ATRA-resistant) cells. moreover, the combination of gefitinib with ATRA and ATO promoted myeloid cell differentiation in ATRA- and ATO-resistant APL cells. In vivo, the combination of gefitinib and ATRA prolonged survival compared to gefitinib- or vehicle-treated leukemic mice in a syngeneic transplantation model, while the gain in survival did not reach statistical difference compared to treatment with ATRA alone. our results suggest that gefitinib is a potential adjuvant agent that can mitigate ATRA and ATO resistance in APL cells. therefore, our data indicate that repurposing FDA-approved tyrosine-kinase inhibitors could provide new perspectives into combination therapy to overcome drug resistance in APL patients

The spectrum of natural forest disturbances and the Amazon forest carbon balance.

Estimates of the atmospheric accumulation of anthropogenic CO2 emissions indicate a large terrestrial carbon sink in recent decades. Intact tropical forests may contribute a substantial fraction of this. While current estimates are based on data from forest inventory plots, these plot studies have been criticized for failure to represent landscape scale processes especially the frequency of severe natural disturbances. Here we characterize the frequency distribution of disturbance events in natural forests from 0.01 ha to 2,651 ha size throughout Amazonia using a novel combination of forest inventory, airborne lidar and satellite remote sensing data. We find that small-scale mortality events are responsible for aboveground biomass losses of about 88.3% over the entire Amazon region. We also find that intermediate-scale disturbances account for losses around 12.7%, and that the largest-scale disturbances as a result of blow-downs only accounts for losses of around 0.02%. Stochastic simulation of growth and mortality based on data from the forest plot census network and the region-wide disturbance spectrum together indicate that rare large disturbances are outweighed by the net biomass gains measured, supporting the inference of a substantial carbon sink in old-growth Amazon forests

Effects of intrauterine food restriction and long-term dietary supplementation with L-arginine on age-related changes in renal function and structure of rats

We have previously demonstrated that restricting intrauterine food by 50% in 3-mo-old rats produced lower nephron numbers and early-onset hypertension, the latter being normalized by L-arginine administration. in 18-mo-old rats, such restriction increased glomerulosclerosis. in this study, we expanded our investigation, evaluating functional, morphologic, and immunohistochemical parameters in intrauterine-food-restricted 18-mo-old rats, either receiving L-arginine (RA18) or not (R18). Age-matched, non-food-restricted controls were assigned to similar groups with L-arginine (CA18) and without (C18). After weaning, L-arginine was given daily for 17 mo. No functional or morphologic changes were observed in C IS rats. the R18 rats developed early-onset hypertension, which persisted throughout the observation period, as well its significant proteinuria from 12 mo on. in RA18 rats, L-arginine decreased both blood pressure levels and proteinuria, and glomerular diameter was si,significantly smaller than in R18 rats (115.63 +/- 2.2 versus 134.8 +/- 1.0 mu m, p < 0.05). However, in RA18 rats, glomerular filtration rate remained depressed. Although L-arginine prevented glomerulosclerosis (R18 = 14%, RA18 = 4%; p < 0.05), glomerular expression of fibronectin and desmin was still greater in RA18 rats than in controls. Our data show that, although L-arginine prevented hypertension and proteinuria, glomerular injury still occurred, suggesting that intrauterine food restriction may be one of the leading causes of impaired renal function in adult life.Universidade Federal de São Paulo, Dept Physiol, EPM, Dept Physiol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, EPM, Dept Morphol,Embrol Div, BR-04023900 São Paulo, BrazilUniv São Paulo, Ribeirao Preto Sch Med, Dept Physiol & Biophys, Brookline, MA 02146 USAUniversidade Federal de São Paulo, Dept Physiol, EPM, Dept Physiol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, EPM, Dept Morphol,Embrol Div, BR-04023900 São Paulo, BrazilWeb of Scienc