Parents, children and the porous boundaries of the sexual family in law and popular culture

This article focuses on a perceived ideological overlap between popular cultural and judicial treatments of sex and conjugality that contributes to a discursive construction of parenthood and parenting. The author perceives that in both legal and popular cultural texts, there is a sense in which notions of ‘natural’ childhood are discursively constituted as being put at risk by those who reproduce outside of dominant sexual norms, and that signs of normative sexuality (typically in the form of heterosexual coupling) may be treated as a sign of safety. These ideas are rooted in ancient associations between fertility, sexuality and femininity that can also be traced in the historical development of the English language. With the help of commentators such as Martha Fineman, the article situates parents and children within a discourse of family which prioritises conjugality, with consequences for the ways in which the internal and external boundaries of families are delineated

Current Regulatory Requirements for Biosimilars in Six Member Countries of BRICS-TM: Challenges and Opportunities

© 2021 Rahalkar, Sheppard, Santos, Dasgupta, Perez-Tapia, Lopez-Morales and Salek. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/Background: The aim of the study was to identify, interpret, and compare the current perspectives of regulatory agencies in six member countries of BRICS-TM (Brazil, Russia, India, China, South Africa, Turkey, and Mexico) on the different criteria used for biosimilar development and marketing authorisation process. Methods: A semi-quantitative questionnaire was developed covering the organisation of agency, biosimilar development criteria and marketing authorisation process and sent to seven regulatory agencies covering the BRICS-TM countries. All data was kept anonymous and confidential. Data processing and analysis was carried out; descriptive statistics were used for quantitative data and content analysis was employed to generate themes for qualitative data. Results: Out of the seven regulatory agencies included in the study, six representatives provided the responses. The perspectives of these six regulatory agencies varied on a number of aspects relating to the review criteria for biosimilar development and licencing process. The most prevalent model for data assessment is the “full review” of a marketing authorisation application. There is lack of a standard approach across the agencies on sourcing of the reference biological product, in vivo toxicity studies and confirmatory clinical studies. Most agencies restrict interaction with biosimilar developers and any scientific advice is non-binding. The marketing authorisation approval depends on scientific assessment of the dossier, sample analysis and GMP certification. The agencies do not issue any public assessment report specifying the summary basis of biosimilar approval. Conclusion: Regulatory agencies across the six emerging economies are steadily improving the regulatory mechanism in the area of biosimilars. However, there remains scope for increasing the effectiveness and efficiency of the processes by encouraging open and transparent interaction with developers, adopting a flexible approach toward accepting advanced analytical data in lieu of clinical studies and enhancing regulatory reliance amongst agencies. This will help to simplify the new biosimilar development programmes and make them more cost-effective.Peer reviewe

A solution for a real-time stochastic capacitated vehicle routing problem with time windows

Real-time distribution planning presents major difficulties when applied to large problems. Commonly, this planning is associated to the capacitated vehicle routing problem with time windows (CVRPTW), deeply studied in the literature. In this paper we propose an optimization system developed to be integrated with an existing Enterprise Resource Planning (ERP) without causing major disruption to the current distribution process of a company. The proposed system includes: a route optimization module, a module implementing the communications within and to the outside of the system, a non-relational database to provide local storage of information relevant to the optimization procedure, and a cartographic subsystem. The proposed architecture is able to deal with dynamic problems included in the specification of the project, namely: arrival of new orders while already optimizing as well as locking and closing of routes by the system administrator. A back-office graphical interface was also implemented and some results are presented

Tensor Trust: Interpretable Prompt Injection Attacks from an Online Game

While Large Language Models (LLMs) are increasingly being used in real-world applications, they remain vulnerable to prompt injection attacks: malicious third party prompts that subvert the intent of the system designer. To help researchers study this problem, we present a dataset of over 126,000 prompt injection attacks and 46,000 prompt-based "defenses" against prompt injection, all created by players of an online game called Tensor Trust. To the best of our knowledge, this is currently the largest dataset of human-generated adversarial examples for instruction-following LLMs. The attacks in our dataset have a lot of easily interpretable stucture, and shed light on the weaknesses of LLMs. We also use the dataset to create a benchmark for resistance to two types of prompt injection, which we refer to as prompt extraction and prompt hijacking. Our benchmark results show that many models are vulnerable to the attack strategies in the Tensor Trust dataset. Furthermore, we show that some attack strategies from the dataset generalize to deployed LLM-based applications, even though they have a very different set of constraints to the game. We release all data and source code at https://tensortrust.ai/pape

Exile Vol. LVIII

Autumn Stiles: Biblical Brooklyn 5 Daniel Carlson: A Night Indoors 6 Moriah Ellenborgen: Cradle Drop 8 Nicco Pandolfi: Cardinality 10 Abby Current: Babies in the Snow 11 Maggie Reagan: Chimaera 13 Natalie Olivo: Treading Water 14 Julianne Hyer: Swatch Watch 21 Mimi Mendes de Leon: For Bosnia 23 A. Tangredi: How to Keep from Freezing 24 Autumn Stiles: Bodies and Bread 25 Christie Maillet: The Depth of a Song 26 Sam Heyman: First Kiss 27 Shawn Whites: Five Hundred Miles to Freedom 28 Ammon Hollister: Temptation 31 Caroline Clutterbuck: The Conspiracy in Your Smile 32 Nicco Pandolfi: Sore Subject 33 Meghan Callahan: Why Claire Left 34 Aaron Bennett: Ode to Arden 36 Daniel Carlson: Duty 37 Lindsey Clark: Snapshot 38 Steph Maniaci: Ode to an M&M 39 Abby Current: The Animal Bride 41 Julianne Hyer: Trees Pantoum 42 Ammon Hollister: Life Support 43 Maggie Reagan: Necropolis 44

Exile Vol. LX

warehousing, Alex Carroll 7 In Search of Suburbia, Jillian Koval 8 Long Distance, Kurt Grahnke 10 [kingdoms], Matthew DeMotts 11 Ice Storm, Nick Holland 12 Coyotes, Matthew DeMotts 20 Honeymoon on Mars, Zoe Drazen 22 Salad, Mia Juratovac 23 Rebirth in Brixton, Mia Juratovac 25 Om Mani Padme Hum, Kelsey Hagarman 26 Between Women, Autumn Stiles 39 A Poem About Why I Don’t Write Poetry, Tori Newman 41 Summer Sweet, Kym Littlefield 44 To Jourdan, Lauren Gustafson 45 Guillotine, Mimi Mendes de Leon 47 Home, Emily Carnavale 54 The Nadir, Emmalee Hagarman 56 May 18th, 1980, Mackenzie Shaw / 5

PCM-Impregnated Textile-Reinforced Cementitious Composite for Thermal Energy Storage

The growing global energy demand requires solutions that improve energy efficiency in all sectors. The civil construction sector is responsible for a large part of global energy consumption. In this context, phase change materials (PCMs) can be incorporated into construction materials to improve the energy efficiency of buildings. The purpose of this study was to incorporate a PCM to jute fabric, applying it in civil construction as a reinforcement for cement matrices. In order to do that, a method of immersing jute fabric in liquid phase change material, and then coating it with a polymer, was proposed. Treated jute fabric was then used to produce a laminated composite with a cementitious matrix. Morphological, mechanical and chemical characterization of jute textiles was performed, as well as an analysis of the composites’ mechanical and thermal behavior. The results verified that jute textiles absorbed 102% PCM in weight, which was successfully contained in the capillary porosity of jute. The PCM was able to delay the composite’s temperature increase by up to 24 °C. It was concluded that this method can be used to incorporate PCM to natural textiles, producing composites with thermal energy storage properties