Red Ink\u27s Pictorial Review of the Langer Administration, 1934

This 32 page, anti-Langer magazine was published by Sam Clark of Bismarck in 1934. Composed mainly of cartoons, Red Ink\u27s Pictorial Review of the Langer Administration highlights the corruption which Clark felt was endemic in the Langer administration.https://commons.und.edu/langer-papers/1074/thumbnail.jp

THE ECONOMICS OF CARCASS BEEF PRODUCTION: AN APPRAISAL OF FLORIDA'S FEEDLOT POTENTIAL

Livestock Production/Industries,

Software for Automated Generation of Cartesian Meshes

Cart3D is a collection of computer programs for generating Cartesian meshes [for computational fluid dynamics (CFD) and other applications] in volumes bounded by solid objects. Aspects of Cart3D at earlier stages of development were reported in "Robust and Efficient Generation of Cartesian Meshes for CFD" (ARC-14275), NASA Tech Briefs, Vol. 23, No. 8 (August 1999), page 30. The geometric input to Cart3D comprises surface triangulations like those commonly generated by computer-aided-design programs. Complexly shaped objects can be represented as assemblies of simpler ones. Cart3D deletes all portions of such an assembled object that are not on the exterior surface. Intersections between components are preserved in the resulting triangulation. A tie-breaking routine unambiguously resolves geometric degeneracies. Then taking the intersected surface triangulation as input, the volume mesh is generated through division of cells of an initially coarse hexahedral grid. Cells are subdivided to refine the grid in regions of increased surface curvature and/or increased flow gradients. Cells that become split into multiple unconnected regions by thin pieces of surface are identified

A nationwide survey of pharmacy students’ knowledge and perceptions regarding medical cannabis

Objective The primary objective of this study was to compare knowledge and perceptions of medical cannabis (MC) between pharmacy students who attended schools where MC was legal and illegal. Design A nationwide anonymous survey regarding MC was distributed to pharmacy students. The survey consisted of the following sections: (1) demographics and personal factors, (2) knowledge assessment of indications and adverse effects of MC, and (3) perceptions assessment. Setting and participants Equal numbers of pharmacy schools were selected and sent surveys based on geographical regions, private versus public universities, and the state’s legal status of MC for first through fourth-year pharmacy students to complete. Outcome measures Student knowledge of MC indications and adverse effects were treated as quizzes. Median percentage correct and whether students passed the quizzes (≥ 70%) were evaluated based on the state’s legal status. Students’ perceptions were similarly compared. Results A total of 629 students accessed the survey. Most students who completed the survey attended pharmacy schools where MC was illegal (55%), were female (68%), and had personally tried cannabis (53%). Overall, 91% of students believed that MC should be legalized nationally. A low number of students correctly identify approved indications with 14.8% of students in states with MC legalization scoring greater than 70% compared with 15.9% of students in states without MC legalization (P = 0.748). Similar findings were seen in the side effects quiz with only 6.1% of students in states with legal MC scoring greater than 70% compared with 7.4% of students where MC is illegal (P = 0.569) There were minimal differences in students’ perceptions of MC based on the states’ legal status. Conclusion Our study continues to highlight that pharmacy students lack knowledge and preparation to counsel and educate on MC. With increasing state legalizations, pharmacy schools need to address this knowledge gap to ensure optimal patient care

Across-Column Cracks and Axial Splits in S2 Saline Ice under Compression

Experiments on plate-like specimens have established that across-column cracks from within S2 (columnar) salt-water ice when compressed uniaxially along a direction inclined to the long axis of the grains. Wing cracks initiate from the across-column cracks and lengthen into axial splits when the ice is rapidly deformed; correspondingly; the macroscopic behavior changes from ductile to brittle. The across-column cracking is attributed to grain-boundary sliding, and the splitting to the suppression of crack-tip creep

The 3D Euler solutions using automated Cartesian grid generation

Viewgraphs on 3-dimensional Euler solutions using automated Cartesian grid generation are presented. Topics covered include: computational fluid dynamics (CFD) and the design cycle; Cartesian grid strategy; structured body fit; grid generation; prolate spheroid; and ONERA M6 wing

Development and application of a 3D Cartesian grid Euler method

This report describes recent progress in the development and application of 3D Cartesian grid generation and Euler flow solution techniques. Improvements to flow field grid generation algorithms, geometry representations, and geometry refinement criteria are presented, including details of a procedure for correctly identifying and resolving extremely thin surface features. An initial implementation of automatic flow field refinement is also presented. Results for several 3D multi-component configurations are provided and discussed

Epigenetics, heritability and longitudinal analysis

Background Longitudinal data and repeated measurements in epigenome-wide association studies (EWAS) provide a rich resource for understanding epigenetics. We summarize 7 analytical approaches to the GAW20 data sets that addressed challenges and potential applications of phenotypic and epigenetic data. All contributions used the GAW20 real data set and employed either linear mixed effect (LME) models or marginal models through generalized estimating equations (GEE). These contributions were subdivided into 3 categories: (a) quality control (QC) methods for DNA methylation data; (b) heritability estimates pretreatment and posttreatment with fenofibrate; and (c) impact of drug response pretreatment and posttreatment with fenofibrate on DNA methylation and blood lipids. Results Two contributions addressed QC and identified large statistical differences with pretreatment and posttreatment DNA methylation, possibly a result of batch effects. Two contributions compared epigenome-wide heritability estimates pretreatment and posttreatment, with one employing a Bayesian LME and the other using a variance-component LME. Density curves comparing these studies indicated these heritability estimates were similar. Another contribution used a variance-component LME to depict the proportion of heritability resulting from a genetic and shared environment. By including environmental exposures as random effects, the authors found heritability estimates became more stable but not significantly different. Two contributions investigated treatment response. One estimated drug-associated methylation effects on triglyceride levels as the response, and identified 11 significant cytosine-phosphate-guanine (CpG) sites with or without adjusting for high-density lipoprotein. The second contribution performed weighted gene coexpression network analysis and identified 6 significant modules of at least 30 CpG sites, including 3 modules with topological differences pretreatment and posttreatment. Conclusions Four conclusions from this GAW20 working group are: (a) QC measures are an important consideration for EWAS studies that are investigating multiple time points or repeated measurements; (b) application of heritability estimates between time points for individual CpG sites is a useful QC measure for DNA methylation studies; (c) drug intervention demonstrated strong epigenome-wide DNA methylation patterns across the 2 time points; and (d) new statistical methods are required to account for the environmental contributions of DNA methylation across time. These contributions demonstrate numerous opportunities exist for the analysis of longitudinal data in future epigenetic studies

Developments at the Advanced Design Technologies Testbed

A report presents background and historical information, as of August 1998, on the Advanced Design Technologies Testbed (ADTT) at Ames Research Center. The ADTT is characterized as an activity initiated to facilitate improvements in aerospace design processes; provide a proving ground for product-development methods and computational software and hardware; develop bridging methods, software, and hardware that can facilitate integrated solutions to design problems; and disseminate lessons learned to the aerospace and information technology communities

VIPER Integrated MDAO Analysis for Conceptual Design of Supersonic X-Plane Vehicles

A streamlined Multi-Disciplinary Analysis and Optimization (MDAO) process is being developed to provide feedback on conceptual designs and early airspace modeling assessments of unconventional aircraft. This MDAO process has been demonstrated using a Low-Boom Flight Demonstrator (LBFD) like configuration by performing a trade study of various flap sizes. The results of this trade showed that shorter takeoff distances are achieved with increased flap chord and flap deflections. This trend is unlike conventional transport type aircraft which typically show increased required takeoff distances due to the increased drag during its take-off flap configurations. The LBFD like configuration results are attributed to its high engine thrust which overcomes the higher drag associated with these takeoff flap configurations