929 research outputs found

    Hexagons, Kinks and Disorder in Oscillated Granular Layers

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    Experiments on vertically oscillated granular layers in an evacuated container reveal a sequence of well-defined pattern bifurcations as the container acceleration is increased. Period doublings of the layer center of mass motion and a parametric wave instability interact to produce hexagons and more complicated patterns composed of distinct spatial domains of different relative phase separated by kinks (phase discontinuities). Above a critical acceleration, the layer becomes disordered in both space and time.Comment: 4 pages. The RevTeX file has a macro allowing various styles. The appropriate style is "myprint" which is the defaul

    Convective Motion in a Vibrated Granular Layer

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    Experimental results are presented for a vertically shaken granular layer. In the range of accelerations explored, the layer develops a convective motion in the form of one or more rolls. The velocity of the grains near the wall has been measured. It grows linearly with the acceleration, then the growing rate slows down. A rescaling with the amplitude of the wall velocity and the height of the granular layer makes all data collapse in a single curve. This can provide insights on the mechanism driving the motion.Comment: 10 pages, 5 figures submitted to Phys. Rev. Let

    A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma

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    Ovarian cancer is the fifth cause of cancer-related mortality in women, with an expected 5-year survival rate of only 47%. High-grade serous carcinoma (HGSC), an epithelial cancer phenotype, is the most common malignant ovarian cancer. It is known that the precursors of HGSC originate from secretory epithelial cells within the Fallopian tube, which first develops as serous tubal intraepithelial carcinoma (STIC). Here, we used gene editing by CRISPR-Cas9 to knock out the oncogene p53 in dog oviductal epithelia cultured in a dynamic microfluidic chip to create an in vitro model that recapitulated human STIC. Similar to human STIC, the gene-edited oviduct-on-a-chip, exhibited loss of cell polarization and had reduced ciliation, increased cell atypia and proliferation, with multilayered epithelium, increased Ki67, PAX8 and Myc and decreased PTEN and RB1 mRNA expression. This study provides a biomimetic in vitro model to study STIC progression and to identify potential biomarkers for early detection of HGSC.</p

    Slow relaxation in granular compaction

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    Experimental studies show that the density of a vibrated granular material evolves from a low density initial state into a higher density final steady state. The relaxation towards the final density value follows an inverse logarithmic law. We propose a simple stochastic adsorption-desorption process which captures the essential mechanism underlying this remarkably slow relaxation. As the system approaches its final state, a growing number of beads have to be rearranged to enable a local density increase. In one dimension, this number grows as N=ρ/(1−ρ)N=\rho/(1-\rho), and the density increase rate is drastically reduced by a factor e−Ne^{-N}. Consequently, a logarithmically slow approach to the final state is found ρ∞−ρ(t)≅1/ln⁥t\rho_{\infty}-\rho(t)\cong 1/\ln t.Comment: revtex, 4 pages, 3 figures, also available from http://arnold.uchicago.edu/~ebn

    Onset of fluidization in vertically shaken granular material

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    When granular material is shaken vertically one observes convection, surface fluidization, spontaneous heap formation and other effects. There is a controversial discussion in literature whether there exists a threshold for the Froude number Γ=A0ω02/g\Gamma=A_0\omega_0^2/g below which these effects cannot be observed anymore. By means of theoretical analysis and computer simulation we find that there is no such single threshold. Instead we propose a modified criterion which coincides with critical Froude number Γc=1\Gamma_c=1 for small driving frequency ω0\omega_0.Comment: 7 pages, 5 figure

    Striking divergences in Earth Observation products may limit their use for REDD+

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    Countries are required to generate baselines of carbon emissions, or Forest Reference Emission Levels, for implementing REDD+ under the United Nations Framework Convention on Climate Change and to access results-based payments. Developing these baselines requires accurate maps of carbon stocks and historical deforestation. Global remote sensing products provide low-cost solutions for this information, but there has been little validation of these products at national scales. This study compares the ability of currently available products obtained from remote sensing data to deliver estimates of deforestation and associated carbon emissions in Guinea-Bissau, a West African country encompassing the climate and vegetation gradients that are typical of sub-Saharan Africa. We show that disagreements in estimates of deforestation are striking, and this variation leads to high uncertainty in derived emissions. For Guinea-Bissau, we suggest that higher temporal resolution of remote sensing products is required to reduce this uncertainty by overcoming current limitations in differentiating deforestation from seasonality. In contrast, existing datasets of carbon stocks show better agreement, and contribute much less to the variation in estimated emissions. We conclude that using global datasets based on Earth Observation data is a cost-effective solution to make REDD+ operational, but deforestation maps in particular should be derived carefully and their uncertainty assessed

    A nonlinear hydrodynamical approach to granular materials

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    We propose a nonlinear hydrodynamical model of granular materials. We show how this model describes the formation of a sand pile from a homogeneous distribution of material under gravity, and then discuss a simulation of a rotating sandpile which shows, in qualitative agreement with experiment, a static and dynamic angle of repose.Comment: 17 pages, 14 figures, RevTeX4; minor changes to wording and some additional discussion. Accepted by Phys. Rev.

    Bifurcations of a driven granular system under gravity

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    Molecular dynamics study on the granular bifurcation in a simple model is presented. The model consists of hard disks, which undergo inelastic collisions; the system is under the uniform external gravity and is driven by the heat bath. The competition between the two effects, namely, the gravitational force and the heat bath, is carefully studied. We found that the system shows three phases, namely, the condensed phase, locally fluidized phase, and granular turbulent phase, upon increasing the external control parameter. We conclude that the transition from the condensed phase to the locally fluidized phase is distinguished by the existence of fluidized holes, and the transition from the locally fluidized phase to the granular turbulent phase is understood by the destabilization transition of the fluidized holes due to mutual interference.Comment: 35 pages, 17 figures, to be published in PR

    Stripes, Pseudogaps, and Van Hove Nesting in the Three-band tJ Model

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    Slave boson calculations have been carried out in the three-band tJ model for the high-T_c cuprates, with the inclusion of coupling to oxygen breathing mode phonons. Phonon-induced Van Hove nesting leads to a phase separation between a hole-doped domain and a (magnetic) domain near half filling, with long-range Coulomb forces limiting the separation to a nanoscopic scale. Strong correlation effects pin the Fermi level close to, but not precisely at the Van Hove singularity (VHS), which can enhance the tendency to phase separation. The resulting dispersions have been calculated, both in the uniform phases and in the phase separated regime. In the latter case, distinctly different dispersions are found for large, random domains and for regular (static) striped arrays, and a hypothetical form is presented for dynamic striped arrays. The doping dependence of the latter is found to provide an excellent description of photoemission and thermodynamic experiments on pseudogap formation in underdoped cuprates. In particular, the multiplicity of observed gaps is explained as a combination of flux phase plus charge density wave (CDW) gaps along with a superconducting gap. The largest gap is associated with VHS nesting. The apparent smooth evolution of this gap with doping masks a crossover from CDW-like effects near optimal doping to magnetic effects (flux phase) near half filling. A crossover from large Fermi surface to hole pockets with increased underdoping is found. In the weakly overdoped regime, the CDW undergoes a quantum phase transition (TCDW→0T_{CDW}\to 0), which could be obscured by phase separation.Comment: 15 pages, Latex, 18 PS figures Corrects a sign error: major changes, esp. in Sect. 3, Figs 1-4,6 replace
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