Антикризисное государственное управление в контексте преодоления проблемы бедности: социологический подход

В статті автори на основі результатів різноманітних соціологічних досліджень розглядають антикризове державне управління як основний інструмент подолання проблеми бідності.In this article the authors, based on the results of various sociological studies, discuss the crisis governance as a key tool to overcome poverty.В статье авторы на основе результатов различных социологических исследований рассматривают антикризисное государственное управление как основной инструмент преодоления проблемы бедности

Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases

Low-density lipoprotein (LDL) plays a key role in the development and progression of atherosclerosis and cardiovascular disease. LDL consists of several subclasses of particles with different sizes and densities, including large buoyant (lb) and intermediate and small dense (sd) LDLs. It has been well documented that sdLDL has a greater atherogenic potential than that of other LDL subfractions and that sdLDL cholesterol (sdLDL-C) proportion is a better marker for prediction of cardiovascular disease than that of total LDL-C. Circulating sdLDL readily undergoes multiple atherogenic modifications in blood plasma, such as desialylation, glycation, and oxidation, that further increase its atherogenicity. Modified sdLDL is a potent inductor of inflammatory processes associated with cardiovascular disease. Several laboratory methods have been developed for separation of LDL subclasses, and the results obtained by different methods can not be directly compared in most cases. Recently, the development of homogeneous assays facilitated the LDL subfraction analysis making possible large clinical studies evaluating the significance of sdLDL in the development of cardiovascular disease. Further studies are needed to establish guidelines for sdLDL evaluation and correction in clinical practice

Use of Natural Products for Direct Anti-Atherosclerotic Therapy

Atherosclerosis and vascular disorders, which result from atherosclerosis, represent one of the major problems in the modern medicine and public health. Atherosclerosis is characterized by structural and functional changes of large arteries. The approaches for the treatment of atherosclerosis require at least the prevention of growth of atherosclerotic lesions and reduction in the lipid core mass, which would followed by plaque stabilization. Taken together, these approaches could theoretically result in the regression of arterial lesions. Atherosclerosis develops in the arterial wall and remains asymptomatic until ischemia of distal organs is evident. Therapy of clinical manifestations of atherosclerosis is largely aimed at reducing symptoms or affecting hemodynamic response and often does not affect the cause or course of disease, namely the atherosclerotic lesion itself. Of course, anti-atherosclerotic effects of statins revealed in many prospective clinical trials may be considered; however, statins have never been recognized as the drugs indicated just for direct treatment or prevention of atherosclerosis. They are used predominately in the course of hypolipidemic therapy, and the effects of treatment are estimated by success in reaching the target level of low density lipoprotein (LDL) cholesterol, but not the regression of atherosclerotic lesion or intimamedia thickness. The last should be considered as beneficial effect, which is mainly due to pleiotropic mechanisms of action. Atherosclerosis develops over many years, so anti-atherosclerotic therapy should be a long-term or even lifelong therapy. Tachyphylaxis, long-term toxicity and cost amongst other issues may present problems for the use of conventional medications in a long-term. Drugs based on natural products can be a good alternative

The prevalence of hypogonadism in men with type 2 diabetes mellitus in clinical practice

BACKGROUND: Hypogonadism is a common complication in men with type 2 diabetes mellitus (DM), but its prevalence remains unknown. AIMS: To estimate the prevalence of hypogonadism in men with type 2 DM. MATERIALS AND METHODS: Male patients with type 2 DM were enrolled into a single-cohort contemporaneous multicenter non-interventional screening study. The study period was from November 2017 through August 2018. Assessments included total testosterone, luteinizing hormone (LH), sex hormone-binding globulin, HbA1c levels. Levels of free testosterone were calculated by Vermeullen method. RESULTS: TheThe median of age of 400 included men was 56 years [51; 58], total testosterone was 12.3 [9.2; 16.5] nmol/l, free testosterone – 270 [217; 334] pmol/l, HbA1c – 7,1% [6.1; 8.6]. Hypogonadism was found in 135 men (33.7%). The total testosterone level in that group was 7.9 [6.8; 9.8] nmol/l, and free testosterone – 192 [164; 227] pmol/l. In hypogonadism-free men their levels were 15,1 [12,4; 18,6] nmol/l and 311 [270; 364] pmol/l, respectively. In most patients with hypogonadism LH level was low, but within normal ranges, and significantly lower than in men without hypogonadism – 3.2 [2.1; 4.7] IU/L vs 3.8 [2.7; 4.9] IU/L, respectively (p=0.007). Most commonly hypogonadism was with normal LH levels (92,6%, median LH level 3.2 [2.2; 4.3] IU/L, p<0,001). The frequency of hypogonadism with high LH level (10.2 [9.2; 14.7] IU/L) and low LH level (1.0 [0.6; 1.1] IU/L) was 4.4% and 3.0%, respectively. CONCLUSIONS: The prevalence of hypogonadism in men with type 2 DM was found to be 33.7%. Normal levels of LH are typical for this type of patients with hypogonadism

The Interaction of Plasma Sialylated and Desialylated Lipoproteins with Collagen from the Intima and Media of Uninvolved and Atherosclerotic Human Aorta

We have evaluated the binding of sialylated and desialylated lipoproteins to collagen isolated from the proteoglycan and musculoelastic layers of intima and media of uninvolved human aorta and atherosclerotic lesions. Comparing various collagen preparations from the uninvolved intima-media, the binding of sialylated apoB-containing lipoproteins was best to collagen from the intimal PG-rich layer. Binding of sialylated apoB-containing lipoproteins to collagen from this layer of fatty streak and fibroatheroma was 1.4- and 3.1-fold lower, respectively, in comparison with normal intima. Desialylated VLDL versus sialylated one exhibited a greater binding (1.4- to 3.0-fold) to all the collagen preparations examined. Desialylated IDL and LDL showed a higher binding than sialylated ones when collagen from the intimal layers of fibroatheroma was used. Binding of desialylated HDL to collagen from the intimal PG-rich layer of normal tissue, initial lesion, and fatty streak was 1.2- to 2.0-fold higher compared with sialylated HDL

Competition of Mesoscales and Crossover to Tricriticality in Polymer Solutions

We show that the approach to asymptotic fluctuation-induced critical behavior in polymer solutions is governed by a competition between a correlation length diverging at the critical point and an additional mesoscopic length-scale, the radius of gyration. Accurate light-scattering experiments on polystyrene solutions in cyclohexane with polymer molecular weights ranging from 200,000 up to 11.4 million clearly demonstrate a crossover between two universal regimes: a regime with Ising asymptotic critical behavior, where the correlation length prevails, and a regime with tricritical theta-point behavior determined by a mesoscopic polymer-chain length.Comment: 4 pages in RevTeX with 4 figure

Prediction of the stochastic behaviour of nonlinear systems by deterministic models as a classical time-passage probabilistic problem

International audienceAssuming that the behaviour of a nonlinear stochastic system can be described by a Markovian diffusion approximation and that the evolution equations can be reduced to a system of ordinary differential equations, a method for the calculation of prediction time is developed. In this approach, the prediction time depends upon the accuracy of prediction, the intensity of turbulence, the accuracy of the initial conditions, the physics contained in the mathematical model, the measurement errors, and the number of prediction variables. A numerical application to zonal channel flow illustrates the theory. Some possible generalizations of the theory are also discussed

Influence of traditions and spiritual practices of east culture on the formation of C.G. Jung’s doctrine

The article deals with the important conceptual foundations borrowed by K.G. Jung from the eastern spiritual, religious and philosophical traditions, which became the foundation of his psychoanalytic teaching. Also the article material analyzes the differences between the eastern and western cultural traditions.В статье рассмотрены важные концептуальные основания, заимствованные К.Г. Юнгом из восточной духовно-религиозной и философской традиции, ставшие фундаментом его сихоаналитического учения. Также на данном материале проанализированы различия восточной и западной культурной традиции

Lagrangian predictability of high-resolution regional models: the special case of the Gulf of Mexico

The Lagrangian prediction skill (model ability to reproduce Lagrangian drifter trajectories) of the nowcast/forecast system developed for the Gulf of Mexico at the University of Colorado at Boulder is examined through comparison with real drifter observations. Model prediction error (MPE), singular values (SVs) and irreversible-skill time (IT) are used as quantitative measures of the examination. Divergent (poloidal) and nondivergent (toroidal) components of the circulation attractor at 50m depth are analyzed and compared with the Lagrangian drifter buoy data using the empirical orthogonal function (EOF) decomposition and the measures, respectively. Irregular (probably, chaotic) dynamics of the circulation attractor reproduced by the nowcast/forecast system is analyzed through Lyapunov dimension, global entropies, toroidal and poloidal kinetic energies. The results allow assuming exponential growth of prediction error on the attractor. On the other hand, the <it>q</it>-th moment of MPE grows by the power law with exponent of 3<it>q</it>/4. The probability density function (PDF) of MPE has a symmetrical but non-Gaussian shape for both the short and long prediction times and for spatial scales ranging from 20km to 300km. The phenomenological model of MPE based on a diffusion-like equation is developed. The PDF of IT is non-symmetric with a long tail stretched towards large ITs. The power decay of the tail was faster than 2 for long prediction times