Interest-Based Self-Organizing Peer-to-Peer Networks: A Club Economics Approach

Improving the information retrieval (IR) performance of peer-to-peer networks is an important and challenging problem. Recently, the computer science literature has attempted to address this problem by improving IR search algorithms. However, in peer-to-peer networks, IR performance is determined by both technology and user behavior, and very little attention has been paid in the literature to improving IR performance through incentives to change user behavior. We address this gap by combining the club goods economics literature and the IR literature to propose a next generation file sharing architecture. Using the popular Gnutella 0.6 architecture as context, we conceptualize a Gnutella ultrapeer and its local network of leaf nodes as a "club" (in economic terms). We specify an information retrieval-based utility model for a peer to determine which clubs to join, for a club to manage its membership, and for a club to determine to which other clubs they should connect. We simulate the performance of our model using a unique real-world dataset collected from the Gnutella 0.6 network. These simulations show that our club model accomplishes both performance goals. First, peers are self-organized into communities of interest - in our club model peers are 85% more likely to be able to obtain content from their local club than they are in the current Gnutella 0.6 architecture. Second, peers have increased incentives to share content - our model shows that peers who share can increase their recall performance by nearly five times over the performance offered to free-riders. We also show that the benefits provided by our club model outweigh the added protocol overhead imposed on the network for the most valuable peers

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.

We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary hormones compared to wild-type littermates, highlighting a role of FOXL2 in the pituitary gonadotrope. Further, we investigate the function of FOXL2 in the gonadotrope cell and determine which domains of the FOXL2 protein are necessary for induction of FSHβ transcription. There is a stronger induction of FSHβ reporter transcription by truncated FOXL2 proteins, but no induction with the mutant lacking the forkhead domain. Specifically, FOXL2 plays a role in activin induction of FSHβ, functioning in concert with activin-induced SMAD proteins. Activin acts through multiple promoter elements to induce FSHβ expression, some of which bind FOXL2. Each of these FOXL2-binding sites is either juxtaposed or overlapping with a SMAD-binding element. We determined that FOXL2 and SMAD4 proteins form a higher order complex on the most proximal FOXL2 site. Surprisingly, two other sites important for activin induction bind neither SMADs nor FOXL2, suggesting additional factors at work. Furthermore, we show that FOXL2 plays a role in synergistic induction of FSHβ by GnRH and activin through interactions with the cJUN component of the AP1 complex that is necessary for GnRH responsiveness. Collectively, our results demonstrate the necessity of FOXL2 for proper FSH production in mice and implicate FOXL2 in integration of transcription factors at the level of the FSHβ promoter

Disc formation in turbulent massive cores: Circumventing the magnetic braking catastrophe

We present collapse simulations of 100 M_{\sun}, turbulent cloud cores threaded by a strong magnetic field. During the initial collapse phase filaments are generated which fragment quickly and form several protostars. Around these protostars Keplerian discs with typical sizes of up to 100 AU build up in contrast to previous simulations neglecting turbulence. We examine three mechanisms potentially responsible for lowering the magnetic braking efficiency and therefore allowing for the formation of Keplerian discs. Analysing the condensations in which the discs form, we show that the build-up of Keplerian discs is neither caused by magnetic flux loss due to turbulent reconnection nor by the misalignment of the magnetic field and the angular momentum. It is rather a consequence of the turbulent surroundings of the disc which exhibit no coherent rotation structure while strong local shear flows carry large amounts of angular momentum. We suggest that the "magnetic braking catastrophe", i.e. the formation of sub-Keplerian discs only, is an artefact of the idealised non-turbulent initial conditions and that turbulence provides a natural mechanism to circumvent this problem.Comment: 6 pages, 5 figures, accepted by MNRAS Letters, updated to final versio

Application of a robotics path planning algorithm to assess the risk of mobile bearing dislocation in lateral unicompartmental knee replacement

Due to ligament laxity, bearing dislocation occurs in 1–6% of Oxford Domed Lateral (ODL) replacements with most dislocations occurring medially. Dislocations were studied using a previously built mechanical rig, however testing using the rig was inefficient. The aim of this study was to develop a better tool that was more reliable and efficient. An established robotics software package, the Open Motion Planning Library, was modified to accept the ODL components. Using a robotics path planning algorithm, the mobile bearing was allowed to find a way out from between the femoral and tibial components i.e. to dislocate. Testing assessed a range of clinically relevant positions of the femoral component relative to the tibial component. Dislocations were labelled as medial, lateral, anterior or posterior depending on the dislocation direction. The Distraction to Dislocation (DD) measured the minimum vertical distraction of the femoral component from the tibial component for a dislocation to occur. Results were validated against the mechanical rig. Statistical analysis of medial dislocation showed excellent agreement with an intraclass correlation value of 0.993 (95% CI 0.982–0.998). All DDs from the dislocation analysis tool were within 1 mm of the mechanical rig DDs with results sharing a remarkably similar trend. The robotics dislocation analysis tool output DDs which were marginally higher than the manual mechanical rig: 0.50 mm anteriorly, 0.25 mm posteriorly and 0.50 mm laterally. Medially, the computational DD differed on average by 0.09 mm (stand deviation: 0.2026 mm). Our study describes the development and validation of a novel robotics dislocation analysis tool, which allows mobile bearing dislocation risk quantification. The tool may also be used to improve surgical implantation parameters and to assess new implant designs that aim to reduce the medial dislocation risk to an acceptable level

Interest-Based Self-Organizing Peer-to-Peer Networks: A Club Economics Approach

Improving the information retrieval (IR) performance of peer-to-peer networks is an important and challenging problem. Recently, the computer science literature has attempted to address this problem by improving IR search algorithms. However, in peer-to-peer networks, IR performance is determined by both technology and user behavior, and very little attention has been paid in the literature to improving IR performance through incentives to change user behavior. We address this gap by combining the club goods economics literature and the IR literature to propose a next generation file sharing architecture. Using the popular Gnutella 0.6 architecture as context, we conceptualize a Gnutella ultrapeer and its local network of leaf nodes as a "club" (in economic terms). We specify an information retrieval-based utility model for a peer to determine which clubs to join, for a club to manage its membership, and for a club to determine to which other clubs they should connect. We simulate the performance of our model using a unique real-world dataset collected from the Gnutella 0.6 network. These simulations show that our club model accomplishes both performance goals. First, peers are self-organized into communities of interest - in our club model peers are 85% more likely to be able to obtain content from their local club than they are in the current Gnutella 0.6 architecture. Second, peers have increased incentives to share content - our model shows that peers who share can increase their recall performance by nearly five times over the performance offered to free-riders. We also show that the benefits provided by our club model outweigh the added protocol overhead imposed on the network for the most valuable peers

Modeling the magnetic field in the protostellar source NGC 1333 IRAS 4A

Magnetic fields are believed to play a crucial role in the process of star formation. We compare high-angular resolution observations of the submillimeter polarized emission of NGC 1333 IRAS 4A, tracing the magnetic field around a low-mass protostar, with models of the collapse of magnetized molecular cloud cores. Assuming a uniform dust alignment efficiency, we computed the Stokes parameters and synthetic polarization maps from the model density and magnetic field distribution by integrations along the line-of-sight and convolution with the interferometric response. The synthetic maps are in good agreement with the data. The best-fitting models were obtained for a protostellar mass of 0.8 solar masses, of age 9e4 yr, formed in a cloud with an initial mass-to-flux ratio ~2 times the critical value. The magnetic field morphology in NGC 1333 IRAS 4A is consistent with the standard theoretical scenario for the formation of solar-type stars, where well-ordered, large-scale, rather than turbulent, magnetic fields control the evolution and collapse of the molecular cloud cores from which stars form.Comment: 4 pages, 5 figures. Accepted by Astronomy and Astrophysic

In vivo evaluation of edge-loading in metal-on-metal hip resurfacing patients with pseudotumours

Objectives: Pseudotumours (abnormal peri-prosthetic soft-tissue reactions) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated metal ion levels, suggesting that excessive wear may occur due to edge-loading of these MoM implants. This study aimed to quantify in vivo edge-loading in MoMHRA patients with and without pseudotumours during functional activities. Methods: The duration and magnitude of edge-loading in vivo was quantified during functional activities by combining the dynamic hip joint segment contact force calculated from the three-dimensional (3D) motion analysis system with the 3D reconstruction of orientation of the acetabular component and each patient’s specific hip joint centre, based on CT scans. Results: Edge-loading in the hips with pseudotumours occurred with a four-fold increase in duration and magnitude of force compared with the hips without pseudotumours (p = 0.02). Conclusions: The study provides the first in vivo evidence to support that edge-loading is an important mechanism that leads to localised excessive wear (edge-wear), with subsequent elevation of metal ion levels in MoMHRA patients with pseudotumours