Substrate heating method for coating metal surfaces with high-silica zeolites: ZSM-5 coatings on stainless steel plates

Syntheses of ZSM-5 coatings on stainless steel plates were carried out via the substrate heating method. The reaction mixture was kept at temperatures below 100 °C, while the metal plates were heated to temperatures above 100 °C. It was demonstrated that continuous ZSM-5 coatings of different textures with different crystal morphologies and void fractions could be formed. ZSM-5 coatings were characterized by X-ray diffraction and scanning electron microscopy. The thickness of the ZSM-5 coatings could be varied depending on the synthesis conditions. Besides providing the opportunity of manipulating coating properties, the method is also beneficial in respect to the synthesis duration as compared to the conventional procedures

Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part I - Modeling and experimental validation

[EN] Adsorption systems driven by engine waste heat are one of the possible alternatives to the conventional automobile air conditioning in terms of energy savings and environmental issues. Assessment of this issue are carried in a two-part study. In this first part I, theoretical and experimental investigations were performed on a two bed, silica gel adsorption chiller for automotive applications. A prototype adsorption system with a total weight of about 86 kg was developed and tested to driven by low-grade waste heat. The single adsorbent bed consisted of three plate-fin heat exchangers connected in parallel. An improved non-equilibrium lumped parameter model was developed to predict the transient performance of the system. The model is fully dynamic and takes into account the mass transfer resistance and pressure drop for each component of the system. The results showed that the model is able to accurately predict the dynamic performance of the system under different operating conditions and configuration modes with a short calculation time. The tested chiller was able to produce an average cooling capacity of about 2.1 kW with a COP of 0.35 at the rated operating conditions. Heat recovery system results in increasing the COP by 43% and the cooling power by 4%. (C) 2016 Elsevier Ltd. All rights reserved.This work has been partially supported by the European project TOPMACS-Thermally Operated Mobile Air-Conditioning Systems, funded by the European Comission under the 6th European Community framework program FP6-SUSTDEV - Sustainable Development, Global Change and Ecosystems: thematic priority 6 under the Focusing and Integrating Community Research programme 2002-2006. (Contract Ref. TST4-CT-2005-012471. The authors are very grateful to the Energy Research Center of Netherlands (ECN) for their support in the experimental work.Verde Trindade, M.; Harby Mohamed Abd Alaal, K.; De Boer, R.; Corberán, JM. (2016). Performance evaluation of a waste-heat driven adsorption system for automotive air-conditioning: Part I - Modeling and experimental validation. Energy. 116:526-538. doi:10.1016/j.energy.2016.09.113S52653811

Five stories & a novel excerpt

Please note: creative writing theses are permanently embargoed in OpenBU. No public access is forecasted for these. To request private access, please click on the lock icon and filled out the appropriate web form.A collection of five short stories, plus the beginning of a novel titled 'There Comes a Day'2999-01-01T00:00:00

Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations, secondary effects, and low ability to attenuate tumor progression. We have developed an alternative means of targeting EGFR that relies on protein degradation through two consecutive routes, ultimately leading to cancer cell detachment-related death. We describe furfuryl derivatives of 4-allyl-5-[2-(4-alkoxyphenyl)-quinolin-4-yl]-4H-1,2,4-triazole-3-thiol that bind to and weakly inhibit EGFR tyrosine phosphorylation and induce strong endocytic degradation of the receptor in cancer cells. The compound-promoted depletion of EGFR resulted in the sequestration of non-phosphorylated Bim, which no longer ensured the integrity of the cytoskeleton machinery, as shown by the detachment of cancer cells from the extracellular matrix (ECM). Of particular note, the longer CH3(CH2)n chains in the terminal moiety of the anti-EGFR molecules confer higher hydrophobicity in the allosteric site located in the immediate vicinity of the catalytic pocket. Small compounds accelerated and enhanced EGFR and associated proteins degradation during EGF and/or glutamine starvation of cultures, thereby demonstrating high potency in killing cancer cells by simultaneously modulating signaling and metabolic pathways. We propose a plausible mechanism of anti-cancer action by small degraders through the allosteric site of EGFR. Our data represent a rational and promising perspective in the treatment of aggressive tumors