Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells.

Acute tissue injury causes DNA damage and repair processes involving increased cell mitosis and polyploidization, leading to cell function alterations that may potentially drive cancer development. Here, we show that acute kidney injury (AKI) increased the risk for papillary renal cell carcinoma (pRCC) development and tumor relapse in humans as confirmed by data collected from several single-center and multicentric studies. Lineage tracing of tubular epithelial cells (TECs) after AKI induction and long-term follow-up in mice showed time-dependent onset of clonal papillary tumors in an adenoma-carcinoma sequence. Among AKI-related pathways, NOTCH1 overexpression in human pRCC associated with worse outcome and was specific for type 2 pRCC. Mice overexpressing NOTCH1 in TECs developed papillary adenomas and type 2 pRCCs, and AKI accelerated this process. Lineage tracing in mice identified single renal progenitors as the cell of origin of papillary tumors. Single-cell RNA sequencing showed that human renal progenitor transcriptome showed similarities to PT1, the putative cell of origin of human pRCC. Furthermore, NOTCH1 overexpression in cultured human renal progenitor cells induced tumor-like 3D growth. Thus, AKI can drive tumorigenesis from local tissue progenitor cells. In particular, we find that AKI promotes the development of pRCC from single progenitors through a classical adenoma-carcinoma sequence

A new species of Diplostephium (Asteraceae, Astereae) from the Atacama Desert, Chile

A new species, Diplostephium paposanum S.T.Ibáñez & Muñoz-Schick, sp. nov., is described for Chile, extending the southern distribution of the genus. Its position within the genus was confirmed by morphological and molecular data, discussed here. The new species was found in a coastal environment, new to the genus, and is geographically far removed from the other Chilean species, which are from the Andes. The formation where it occurs, known as lomas, acts as a biodiversity refuge in hyperarid environments. The presence of D. paposanum in this environment contributes to the evidence of a floristic connection between the Atacama Desert and the Neotropical Andes

The European Local ENergy Assistance (ELENA) Fund: The Relevance of Expected and Unexpected Partnerships

Energy efficiency investments are one of the relevant aspects of Energy Transition. The role of municipalities in the investment process is really relevant, since they directly own a lot of buildings and they can have a huge impact on the territory. The lack of competences in a technical aspects and lack of funding prevent the possibility to put in place huge investments. The ELENA Fund is one of the tool put in place by the EU to help in activating green investments in urban areas. During the funding process a lot of partnerships at different levels are put in place: without a proper regulation, the effect of these partnerships on projects\u2019 results is unpredictable

The vascular plant flora of the Bellotos del Melado National Reserve, VII Region, Chile: A documented checklist

Volume: 57Start Page: 117End Page: 13

The flora of Llullaillaco National Park located in the transitional winter-summer rainfall area of the Northern Chilean Andes

Volume: 55Start Page: 93End Page: 11

Riconoscimento e comunità. A partire da Hegel

"Archivio di Filosofia", LXXVII, 2009, n. 2-