Intraoral Sialadenoma Papilliferum: A Comprehensive Review of the Literature with Emphasis on Clinical and Histopathological Diagnostic Features

Sialadenoma papilliferum (SP) is a rare benign epithelial tumor of salivary gland origin, its diagnosis being potentially challenging. It was first described by Abrams and Finck in 1969 as an analog of the cutaneous syringocystadenoma papilliferum. The aim of this comprehensive review is to highlight the clinical and histopathological diagnostic aspects of intraoral SP, analyzing cases previously described and reporting new cases. Methods. Medline, Scopus, and Web of Science were searched up to February 2022, using as entry term “sialadenoma papilliferum”. No time limits were applied and only studies in English were taken into account. Only cases involving the mouth were included. Conference proceedings, personal communications, and letters to the editor were excluded. Results. In total, 42 out of 234 articles fulfilled the inclusion criteria, with 64 cases reported. Mean age of patients with SP was 57.2 years, with a higher prevalence among males. The most affected site was the palate, particularly the hard palate. Four cases with uncertain malignant features have been reported. While clinical manifestations of SP are rather unspecific (e.g., submucosal swelling with ulceration), histopathological and immunohistochemical features are quite peculiar, SP have a limited growth potential, leading to conservative excision as treatment of choice. Conclusions. SP, though rare, should be taken into consideration in the differential diagnosis of intraoral swellings, particularly those located on the palate

"Drug holiday" in DRONJ (Denosumab Related Osteonecrosis of the Jaws) patients : real benefit in surgical or non surgical therapeutic approach ?

One of the most frequent monoclonal antibodies linked to MRONJ is Denosumab. In our study, attention was focused on different therapeutic approaches considering patients treated only with Denosumab or in combination with other drugs associated with the genesis of ONJ. We considered two different clinical approaches: sites treated without surgery; sites treated with traditional surgery or Er:YAG laser (2940nm, 250mJ, 20Hz). In our study, the discontinuation of the drug was evaluated in relation to treatment outcomes

MRONJ and implants: the risk of developing necrosis away from surgery

This study aimed to evaluate the prevalence of MRONJ in patients treated with prosthetic implant rehabilitation. We evaluated the risk of MRONJ genesis comparing implant surgery with the development of necrosis after correct implant osteointegration. The implants' presence in these patients is a possible risk factor of necrosis development. The presence of implant might cause a reactivation of osteoclasts

Caracterização molecular de bovinos cruzados ½ Angus ½ Nelore e ½ Canchim ½ Nelore.

Os cruzamentos entre raças de bovinos têm sido uma alternativa para a exploração de características de produção e qualidade da carne de raças de Bos taurus especializadas e da adaptação aos trópicos de raças de Bos indicus. A raça de bovinos Aberdeen Angus tem sido utilizada em cruzamentos com Nelore, particularmente por suas características favoráveis de qualidade da carne, além de boa fertilidade, longevidade, precocidade, rusticidade e facilidade de parto. A raça Canchim, constituída por 5/8 Charolês e 3/8 Zebu, apresenta-se como excelence altemativa para cruzamentos pois permite a utilização de couros em monta natural em regime de pastagens. No presente trabalho, produtos do cruzamento de touros Aberdeen Angus (TA) e Canchim (RC) com fêmeas da raça Nelore foram caracterizados quanto a cinco marcadores microssatelites. Os marcadores foram amplificados a partir de 50 ng de DNA genômico e analisados em um sequênciador ABI Prism 3100 .A:vant (Applied Biosystems). Os alemos foram identificados pelo programa Genotyper (Applied Biosyscems), a partir do que foram estimadas as frequências alélicas, heterozigosidade, diversidade gênica, conteúdo de informaçãopolim6rfica'pelo software Cervus e a distancia genética de Nei (1972), utilizando o software NTSYS PC. O numero de alelos variou de 2 a 17, com media de 8,2 nos animais TA e 9,8 nos animais RC. As medias de heterozigosidade foram de 0,7472 e 0,695 para os animais TA e RC, respectivamente. As medias de diversidade gênica foram de 0,756 e 0,6268, na mesma ordem, sugerindo. A distancia genética entre ''as duas populações foi de 0,2273. Essa distancia e comparável a distancia observada entre os grupos Bos taurus e Bas indicus e deve refletir a distancia entre os couros das raças Aberdeen Angus e Canchim, uma vez que nas duas populações, a raça materna foi a mesma

Detecting volcanic sulfur dioxide plumes in the Northern Hemisphere using the Brewer spectrophotometer, other networks, and satellite observations

This paper demonstrates that SO 2 columnar amounts have significantly increased following the five largest volcanic eruptions of the past decade in the Northern Hemisphere. A strong positive signal was detected by all the existing networks either ground based (Brewer, EARLINET, AirBase) or from satellites (OMI, GOME-2). The study particularly examines the adequacy of the existing Brewer network to detect SO 2 plumes of volcanic origin in comparison to other networks and satellite platforms. The comparison with OMI and 45 GOME-2 SO 2 space-borne retrievals shows statistically significant agreement between the Brewer network data and the collocated satellite overpasses. It is shown that the Brewer instrument is capable of detecting significant columnar SO 2 increases following large volcanic eruptions, when SO 2 levels rise well above the instrumental noise of daily observations, estimated to be of the order of 2 DU. A model exercise from the MACC project shows that the large increases of SO 2 over Europe following the Bárðarbunga eruption in Iceland were not caused by local sources or ship emissions but are clearly linked to the eruption. We propose that by combining Brewer data with that from other networks and satellites, a useful tool aided by trajectory analyses and modeling could be created which can be used to forecast high SO 2 values both at ground level and in air flight corridors following future eruptions

COMPETENCIAS INTERPROFESIONALES NUCLEARES EN SALUD: UN ESTUDIO TEÓRICO

Changes in the epidemiological profile, resulting from increased life expectancy and chronic health conditions, bring the need for comprehensive care, capable of addressing the biopsychosocial needs of individuals, groups and populations. Therefore, in order to improve collaboration and the quality of health care in an interactive way, there is Interprofessional Education, understood as a process of preparing people for collaborative practice, which encompasses six domains of competences to be developed in professionals to promote essential knowledge, skills, attitudes and values. This study aims to present and analyze interprofessional education and its respective domains from the perspective of the document entitled Canadian Interprofessional Health Collaborative, reflecting on academic training and health practices in the country. This is a theoretical study that individually discusses interprofessional competences and their development for a better quality of care provided in health services. It is concluded that training and education in health should enable a critical reflection on the transformations and actions of professionals in the health context, fostering the consolidation of user-centered care from a biopsychosocial perspective.Los cambios en el perfil epidemiológico, resultantes del aumento de la esperanza de vida y de las condiciones crónicas de salud, traen consigo la necesidad de una atención integral, capaz de atender las necesidades biopsicosociales de individuos, grupos y poblaciones. Por tanto, para mejorar la colaboración y la calidad de la atención en salud de forma interactiva, existe la Educación Interprofesional, entendida como un proceso de preparación de las personas para la práctica colaborativa, que engloba seis dominios de competencias a desarrollar en los profesionales para promover los conocimientos esenciales, habilidades, actitudes y valores. Este estudio tiene como objetivo presentar y analizar la educación interprofesional y sus respectivos dominios en la perspectiva del documento titulado Canadian Interprofessional Health Collaborative, reflexionando sobre la formación académica y las prácticas de salud en el país. Se trata de un estudio teórico que discute individualmente las competencias interprofesionales y su desarrollo para una mejor calidad de la atención prestada en los servicios de salud. Se concluye que la formación y la educación en salud deben posibilitar una reflexión crítica sobre las transformaciones y acciones de los profesionales en el contexto de la salud, favoreciendo la consolidación del cuidado centrado en el usuario desde una perspectiva biopsicosocial.As mudanças de perfil epidemiológico, consequentes do aumento da expectativa de vida e das condições crônicas de saúde, trazem a necessidade da integralidade do cuidado, capaz de contemplar as necessidades biopsicossociais de indivíduos, grupos e populações. Logo, no intuito de melhorar a colaboração e qualidade da atenção em saúde de modo interativo, tem-se a Educação Interprofissional, entendida como um processo de preparação de pessoas para a prática colaborativa, que abarca seis domínios de competências a serem desenvolvidos nos profissionais para promover os conhecimentos, habilidades, atitudes e valores essenciais. Esse estudo tem por objetivo apresentar e analisar a educação interprofissional e seus respectivos domínios na perspectiva do documento intitulado Canadian Interprofessional Health Collaborative, refletir sobre a formação acadêmica e as práticas em saúde no País. Trata-se de um estudo teórico que discute individualmente as competências interprofissionais e o seu desenvolvimento para uma melhor qualidade no atendimento prestado nos serviços de saúde. Conclui-se que a formação e a educação na saúde deve possibilizar uma reflexão crítica sobre as transformações e a atuação de profissionais no contexto da saúde fomentando a consolidação do cuidado centrado no usuário em uma perspectiva biopsicossocial.As mudanças de perfil epidemiológico, consequentes do aumento da expectativa de vida e das condições crônicas de saúde, trazem a necessidade da integralidade do cuidado, capaz de contemplar as necessidades biopsicossociais de indivíduos, grupos e populações. Logo, no intuito de melhorar a colaboração e qualidade da atenção em saúde de modo interativo, tem-se a Educação Interprofissional, entendida como um processo de preparação de pessoas para a prática colaborativa, que abarca seis domínios de competências a serem desenvolvidos nos profissionais para promover os conhecimentos, habilidades, atitudes e valores essenciais. Esse estudo tem por objetivo apresentar e analisar a educação interprofissional e seus respectivos domínios na perspectiva do documento intitulado Canadian Interprofessional Health Collaborative, refletir sobre a formação acadêmica e as práticas em saúde no País. Trata-se de um estudo teórico que discute individualmente as competências interprofissionais e o seu desenvolvimento para uma melhor qualidade no atendimento prestado nos serviços de saúde. Conclui-se que a formação e a educação na saúde deve possibilizar uma reflexão crítica sobre as transformações e a atuação de profissionais no contexto da saúde fomentando a consolidação do cuidado centrado no usuário em uma perspectiva biopsicossocial

THE EFFECTS OF LOW LEVEL LASER THERAPY ON PROLIFERATION AND DIFFERENTIATION OF MESENCHIMAL STEM CELLS: A LITERATURE REVIEW

Utilization of a low-energy light intensity within the visible red and near infrared portion of the electromagnetic spectrum has been shown to stimulate irradiated cellular activity. This phenomenon has been referred to as photobiomodulation (PBM) or low level laser therapy (LLLT). Many cellular responses have been observed after photobiomodulation, including increase of mitochondrial respiration and ATP production, the synthesis of proteins and cell migration, proliferation and differentiation. Few studies have investigated the use of LLLT on Mesenchimal stem cells (MSCs) in order to promote proliferation and/or differentiation. The aim of this literature review is to highlight the current findings about the effects of PBM on proliferation and differentiation of mesenchimal stem cells. The parameters used to perform LLLT will also be evaluated. The electronic search was conducted with PubMed database for English-language articles published until May 2019. Following 14 MeSH terms and keywords were used in combination and/or separately: Low Level Laser Therapy; Low Level Light Therapy; Low Level Laser Irradiation; Low Level Light Irradiation; LLLT; LLLI; Stem Cells; Bone Marrow; Adipose; Periodontal Ligament; Dental Pulp; Mesenchymal; Cell Proliferaton; Cell Differentiation. The selection of studies was initiated by the review of articles’ titles and the eligible papers were classified as in vivo or in vitro experimental studies which assessed the use of PBM on dental (DMSC), adipose (ADSC) or bone marrow (BMSC) stem cells in order to promote their proliferation and/or differentiation. Articles without a case-control design were excluded. Articles found after first research were 430 and 338 papers were excluded after screening of titles and abstracts. Fifty-nine papers were excluded after full text analysis. From the preliminary list of papers, 33 articles met the search criteria and were included in the present review. All reviewed papers showed positive outcomes both for proliferation’s and differentiation’s rates exept for two. In vivo studies were 7 (21%), while in vitro studies were 26 (79%); 31 papers evaluated proliferation rate and 16 papers (48,5%) evaluated differentiation rate. The most widely used stem cells were BMSC (13 papers, 39,4%). Results shows that most frequently PBM was performed with diode laser (InGaAlP) (13 papers, 39,4%), with visible wavelengths of 660nm (17 papers, 52%) and Fluence values between 0.5 e 5 J/ (24 papers, 73%). Low-level laser therapy has positive and stimulatory effects on the proliferation and differentiation of stem cells. With the appropriate use of LLLT the proliferation and/or differentiation rate of cultured stem cells (MSCs), can be increased, which would be very useful in tissue engineering and regenerative medicine