Statistical models and the theory of hypothesis testing in medicine

Purpose: The purpose of this work is to develop statistical approaches for treatment efficiency analysis on a medical case. These methods include the effect evaluation method performed with various preparations in regards to several factors such as the patient‘s blood state and his/her biochemical values. Design/Methodology/Approach: The results of this survey were divided into three groups: the first included the blood biochemistry values before the test, the second — an hour after the test, the the third — two hours after the test. When visually comparing the results of the analyses of the three groups, it was possible to assume that the load of FLC did not significantly affect the biochemistry of the patients' blood. To test this medical assumption, various statistical criteria of the theory of testing statistical hypotheses have been applied. Findings: Statistical analysis of changes in the level of lipase and triglycerides in the biochemical analysis of the blood of patients with chronic pancreatitis after ingestion of food containing medium-chain fatty acids showed that there is no overall disruption in the functioning of the pancreas. Practical implications: Clinical practice has shown that more than 85% of patients tolerated testing with medium chain fatty acids, not experiencing a painful abdominal symptom and other negative consequences of a violation of external secretion of the pancreas. Originality/Value: In clinical practice, the Russian Academy of Medical Sciences for the first time took into account the results of a statistical analysis.peer-reviewe

Management tactics for children with persistent cough

The paper presents the results of comprehensive examination and treatment in 514 children who have developed a persistent cough lasting for more than 3 weeks after acute respiratory disease. The cause of persistent coughing was a concurrence of infectious and somatic diseases in the majority of cases (62.8%). Among the somatic diseases, there were most common allergic diseases of respiratory organs (32.4%) and ENT diseases (27.4%). 311 (60.5%) children were found to have markers for Mycoplasma (43.9%), herpesvirus (42.2%), Pneumocystis (21.4%), and Chlamydia (6.25%) infections as mono- or mixed infections. Combination therapy with Cycloferon had a positive clinical effect. Based on the findings, the authors elaborated a diagnostic algorithm and proposed a treatment policy in children with a persistent cough after acute respiratory infection

The terrestrial and freshwater invertebrate biodiversity of the archipelagoes of the Barents Sea; Svalbard, Franz Josef Land and Novaya Zemlya

Arctic terrestrial ecosystems are generally considered to be species poor, fragile and often isolated. Nonetheless, their intricate complexity, especially that of the invertebrate component, is beginning to emerge. Attention has become focused on the Arctic both due to the importance of this rapidly changing region for the Earth and also the inherent interest of an extreme and unique environment. The three archipelagoes considered here, Svalbard, Franz Josef Land and Novaya Zemlya, delineate the Barents Sea to the west, north and east. This is a region of convergence for Palearctic and Nearctic faunas re-colonising the Arctic following the retreat of the ice after the Last Glacial Maximum (LGM). Despite the harsh Arctic environment and the short period since deglaciation, the archipelagoes of the Barents Sea are inhabited by diverse invertebrate communities. But there is an obvious imbalance in our knowledge of many taxa of each archipelago, and in our knowledge of many taxa. Research effort in Svalbard is increasing rapidly while there are still few reports, particularly in the western literature, from Franz Josef Land and Novaya Zemlya. Nevertheless, there appears to be a surprising degree of dissimilarity between the invertebrate faunas, possibly reflecting colonization history. We provide a baseline synthesis of the terrestrial and freshwater invertebrate fauna of the Barents Sea archipelagoes, highlight the taxa present, the characteristic elements of fauna and the complexity of their biogeography. In doing so, we provide a background from which to assess responses to environmental change for a region under increasing international attention from scientific, industrial and political communities as well as non-governmental organizations and the general public