1,656 research outputs found
Preliminary vegetation map of the Espenberg Peninsula, Alaska, based on an Earth Resources Technology Satellite image
There are no author-identified significant results in this report
Low absorption InP/InGaAs-MQW phase shifters for optical switching
InP/InGaAs-MQW phase shifters with low absorption loss and low electroabsorption loss have been realized. Phase shift efficiency for TE-polarized light at lambda =1.55 mu m was 6.8 degrees V/sup -1/ mm/sup -1/ with negligible absorption loss and at lambda =1.51 mu m the efficiency was 8.9 degrees V/sup -1/ mm/sup -1/ with 5 dB/cm absorption los
Individual scatterers as microscopic origin of equilibration between spin- polarized edge channels in the quantum Hall regime
The equilibration length between spin-polarized edge states in the Quantum
Hall regime is measured as a function of a gate voltage applied to an electrode
on top of the edge channels. Reproducible fluctuations in the coupling are
observed and interpreted as a mesoscopic fingerprint of single spin-flip
scatterers which are turned on and off. A model to analyze macroscopic edge
state coupling in terms of individual scatterers is developed, and
characteristic values for these scatterers in our samples are extracted. For
all samples investigated, the distance between spin-flip scatterers lies
between the Drude and the quantum scattering length.Comment: 4 pages, 2 figure
Characterization of a POROS\u3csup\u3eTM\u3c/sup\u3e-fumonisin B1 Affinity Column for Isolating Ceramide Synthase from Rat Liver
Fumonisin B1 is a mycotoxin produced by fungi of the genus Fusarium, common pathogens of corn and other grain plants. Toxic effects associated with fumonisin B1 include equine leukoencephalomacia, porcine pulmonary edema, rat renal carcinoma, and murine hepatocellular carcinoma. Increased risk for esophageal cancer in humans has been epidemiologically associated with consumption of corn contaminated with Fusarium, suggesting that fumonisin B1 may be involved. The biological effects of fumonisin B1 exposure result primarily from disruption of de novo sphingolipid biosynthesis via inhibition of ceramide synthase. Exposure of animals or cultured cells to fumonisin B1 results in the characteristic accumulation of sphinganine, a toxic sphingolipid intermediate, concomitant with depletion of essential complex sphingolipids. Ceramide synthase has not been purified to homogeniety and characterized. We prepared crude ceramide synthase from detergent-extracted rat liver homogenates using PEG-precipitation and cation exchange chromatography. Ceramide synthase activity was then sequestered, using fumonisin B1 covalently coupled to POROS-NH particles, and eluted selectively. The observed 119-fold enrichment in specific activity demonstrates the utility of fumonisin-POROS affinity chromatography in the purification of ceramide synthase
Signals for Lorentz Violation in Post-Newtonian Gravity
The pure-gravity sector of the minimal Standard-Model Extension is studied in
the limit of Riemann spacetime. A method is developed to extract the modified
Einstein field equations in the limit of small metric fluctuations about the
Minkowski vacuum, while allowing for the dynamics of the 20 independent
coefficients for Lorentz violation. The linearized effective equations are
solved to obtain the post-newtonian metric. The corresponding post-newtonian
behavior of a perfect fluid is studied and applied to the gravitating many-body
system. Illustrative examples of the methodology are provided using bumblebee
models. The implications of the general theoretical results are studied for a
variety of existing and proposed gravitational experiments, including lunar and
satellite laser ranging, laboratory experiments with gravimeters and torsion
pendula, measurements of the spin precession of orbiting gyroscopes, timing
studies of signals from binary pulsars, and the classic tests involving the
perihelion precession and the time delay of light. For each type of experiment
considered, estimates of the attainable sensitivities are provided. Numerous
effects of local Lorentz violation can be studied in existing or near-future
experiments at sensitivities ranging from parts in 10^4 down to parts in
10^{15}.Comment: 46 pages two-column REVTeX, accepted in Physical Review
The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma
BACKGROUND: Bone pain in malignancy can be challenging to treat. Bisphosphonates have been found to be useful in adults with bone pain, but there are no reports of their use in children for this indication. In pediatric palliative medicine there are hurdles in translating knowledge gained primarily in adult studies into application in children. Obstacles exist in initially determining whether the evidence supports using a drug in children, and once a drug is chosen, then determining the optimal route of delivery. There is very little data to guide pediatric practitioners in this situation. CASE PRESENTATION: A 9 year old boy with disseminated Ewing Sarcoma presented with extremity pain not responsive to a combination of opiates, gabapentin and non-steroidal anti-inflammatory drugs. Clodronate, a bisphosphonate, was added to the regimen to treat bone pain. It was given subcutaneously every 4 weeks with a good response and no side effects. CONCLUSION: This case report describes the use of a bisphosphonate, clodronate, given subcutaneously to a child with Ewing sarcoma with effective relief of bone pain. It describes how the care team encountered the challenges inherent in translating adult therapy into a pediatric regimen. Furthermore the report details how a regimen was developed to address this child's concerns regarding medication administration. Further effort needs to be made at finding solutions to address the lack of good evidence for pediatric palliative therapies
Difference Image Analysis of Galactic Microlensing I. Data Analysis
This is a preliminary report on the application of Difference Image Analysis
(DIA) to galactic bulge images. The aim of this analysis is to increase the
sensitivity to the detection of gravitational microlensing. We discuss how the
DIA technique simplifies the process of discovering microlensing events by
detecting only objects which have variable flux. We illustrate how the DIA
technique is not limited to detection of so called ``pixel lensing'' events,
but can also be used to improve photometry for classical microlensing events by
removing the effects of blending. We will present a method whereby DIA can be
used to reveal the true unblended colours, positions and light curves of
microlensing events. We discuss the need for a technique to obtain the accurate
microlensing time scales from blended sources, and present a possible solution
to this problem using the existing HST colour magnitude diagrams of the
galactic bulge and LMC. The use of such a solution with both classical and
pixel microlensing searches is discussed. We show that one of the major causes
of systematic noise in DIA is differential refraction. A technique for removing
this systematic by effectively registering images to a common airmass is
presented. Improvements to commonly used image differencing techniques are
discussed.Comment: 18 pages, 8 figures, uses AAS LaTEX 4.0, To appear in Astrophysical
Journa
Evidence for Ubiquitous, High-EW Nebular Emission in z~7 Galaxies: Towards a Clean Measurement of the Specific Star Formation Rate using a Sample of Bright, Magnified Galaxies
Growing observational evidence now indicates that nebular line emission has a
significant impact on the rest-frame optical fluxes of z~5-7 galaxies observed
with Spitzer. This line emission makes z~5-7 galaxies appear more massive, with
lower specific star formation rates. However, corrections for this line
emission have been very difficult to perform reliably due to huge uncertainties
on the overall strength of such emission at z>~5.5. Here, we present the most
direct observational evidence yet for ubiquitous high-EW [OIII]+Hbeta line
emission in Lyman-break galaxies at z~7, while also presenting a strategy for
an improved measurement of the sSFR at z~7. We accomplish this through the
selection of bright galaxies in the narrow redshift window z~6.6-7.0 where the
IRAC 4.5 micron flux provides a clean measurement of the stellar continuum
light. Observed 4.5 micron fluxes in this window contrast with the 3.6 micron
fluxes which are contaminated by the prominent [OIII]+Hbeta lines. To ensure a
high S/N for our IRAC flux measurements, we consider only the brightest
(H_{160}<26 mag) magnified galaxies we have identified in CLASH and other
programs targeting galaxy clusters. Remarkably, the mean rest-frame optical
color for our bright seven-source sample is very blue, [3.6]-[4.5]=-0.9+/-0.3.
Such blue colors cannot be explained by the stellar continuum light and require
that the rest-frame EW of [OIII]+Hbeta be greater than 637 Angstroms for the
average source. The bluest four sources from our seven-source sample require an
even more extreme EW of 1582 Angstroms. Our derived lower limit for the mean
[OIII]+Hbeta EW could underestimate the true EW by ~2x based on a simple
modeling of the redshift distribution of our sources. We can also set a robust
lower limit of >~4 Gyr^-1 on the specific star formation rates based on the
mean SED for our seven-source sample. (abridged)Comment: 9 pages, 6 figures, 1 table, submitted to the Astrophysical Journa
The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes
In the proximity of melting transitions of artificial and biological
membranes fluctuations in enthalpy, area, volume and concentration are
enhanced. This results in domain formation, changes of the elastic constants,
changes in permeability and slowing down of relaxation processes. In this study
we used pressure perturbation calorimetry to investigate the relaxation time
scale after a jump into the melting transition regime of artificial lipid
membranes. This time corresponds to the characteristic rate of domain growth.
The studies were performed on single-component large unilamellar and
multilamellar vesicle systems with and without the addition of small molecules
such as general anesthetics, neurotransmitters and antibiotics. These drugs
interact with membranes and affect melting points and profiles. In all systems
we found that heat capacity and relaxation times are related to each other in a
simple manner. The maximum relaxation time depends on the cooperativity of the
heat capacity profile and decreases with a broadening of the transition. For
this reason the influence of a drug on the time scale of domain formation
processes can be understood on the basis of their influence on the heat
capacity profile. This allows estimations of the time scale of domain formation
processes in biological membranes.Comment: 12 pages, 6 figure
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