Beyond retrieval: A proposal to expand the design space of classification

In Information Science, the creation of classification schemes has been more commonly described in the mode of scientific discovery, as opposed to artifact design. From the literary warrant of Hulme to the terminological warrant of the Classification Research Group (CRG), to Hjørland’s domain analysis, the classificationist seems like one who documents and compiles, and not one who actively shapes design. Outside of Information Science, however, classification is used as an active argument to structure interpretations (in linguistics and philosophy) and as a means of coordinating and imposing order on work practices (in studies of information systems). In this paper, I suggest that classification researchers should investigate a wider variety of design possibilities, in which the purpose of a classification is not assumed to be a retrieval tool in the traditional manner. A consequence of an expanded design space is that standard classification manuals and guides become insufficient support for the design process; a new research area might be the facilitation of problem-setting aspects of classification design. One avenue of possible research involves the description of a design language, following the description of such by Lowgren and Stolterman (2004) and Donald Schon (1983). A design language, which might be operationalized as a set of product qualities, might provide a framework by which designers can better understand, evaluate, and create classifications

AN EXAMINATION OF AUTHORITY IN SOCIAL CLASSIFICATION SYSTEMS

Champions of social classification praise its flexible and collaborative nature, in contrast to the rigidity and authoritarianism that they see in traditional classificative structures (such as Kroski, 2005; Shirky, 2005c; Merholz, 2004). In the view of these writers, social classification applications such as the photo storage Web site Flickr and the Web bookmarks manager del.icio.us are both democratic, incorporating the participation of all Web users, and emergent, changing rapidly in response to new content. On the other hand, traditional methods for organizing information, particularly those that involve hierarchy, are seen as exclusive, because they may not represent all users’ viewpoints, and imprecise, because they cannot be easily adapted for the rapid pace of content development engendered by Web publishing

Reading databases: slow information interactions beyond the retrieval paradigm

Purpose In this conceptual essay, the purpose of this paper is to argue that the structure of databases and other information systems provides valuable information beyond their content. The author contends that reading databases – as a separate, distinct activity from retrieving and reading the documents that databases contain – is an under-studied form of human-information interaction. Because the act of reading databases encourages awareness, reflection, and control over information systems, the author aligns the author’s proposal with “slow” principles, as exemplified by the slow food movement. Design/methodology/approach This paper presents an extended argument to demonstrate the value of reading a database. Reading a database involves understanding the relationship between database structure and database content as an interpretation of the world. For example, when a supermarket puts vermicelli in the pasta section but rice vermicelli in the Asian section, the supermarket suggests that rice vermicelli is more “Asian” than “noodle.” To construct the author’s argument, the author uses examples that range from everyday, mundane activities with information systems (such as using maps and automated navigation systems) to scientific and technical work (systematic reviews of medical evidence). Findings The slow, interpretively focused information interactions of reading databases complement the “fast information” approach of outcome-oriented retrieval. To facilitate database reading activities, research should develop tools that focus user attention on the application of database structure to database contents. Another way of saying this is that research should exploit the interactive possibilities of metadata, either human-created or algorithmically generated. Originality/value This paper argues that information studies research focuses too heavily on seeking and retrieval. Seeking and retrieval are just two of the many interactions that constitute our everyday activities with information. Reading databases is an area particularly ripe with design possibilities. </jats:sec

AN EXAMINATION OF AUTHORITY IN SOCIAL CLASSIFICATION SYSTEMS

Champions of social classification praise its flexible and collaborative nature, in contrast to the rigidity and authoritarianism that they see in traditional classificative structures (such as Kroski, 2005; Shirky, 2005c; Merholz, 2004). In the view of these writers, social classification applications such as the photo storage Web site Flickr and the Web bookmarks manager del.icio.us are both democratic, incorporating the participation of all Web users, and emergent, changing rapidly in response to new content. On the other hand, traditional methods for organizing information, particularly those that involve hierarchy, are seen as exclusive, because they may not represent all users’ viewpoints, and imprecise, because they cannot be easily adapted for the rapid pace of content development engendered by Web publishing

DNA methylation-based measures of biological age:meta-analysis predicting time to death

Estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of chronological age, epigenetic age assessed in blood predicted all-cause mortality in four human cohorts. Here, we expanded our original observation to 13 different cohorts for a total sample size of 13,089 individuals, including three racial/ethnic groups. In addition, we examined whether incorporating information on blood cell composition into the epigenetic age metrics improves their predictive power for mortality. All considered measures of epigenetic age acceleration were predictive of mortality (p ≤ 8.2 x 10-9), independent of chronological age, even after adjusting for additional risk factors (p < 5.4 x 10-4), and within the racial/ethnic groups that we examined (non-Hispanic whites, Hispanics, African Americans). Epigenetic age estimates that incorporated information on blood cell composition led to the smallest p-values for time to death (p≤ 7.5 x 10-43). Overall, this study a) strengthens the evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors, and b) demonstrates that epigenetic age estimates that incorporate information on blood cell counts lead to highly significant associations with all-cause mortality

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. RESULTS: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P < 1.15 × 10-7) in the discovery panel of European ancestry and replicated (P < 2.29 × 10-4) 58 CpG sites (45 unique loci) among African Americans. To further characterize the molecular and clinical relevance of the findings, we examined the association with gene expression, genetic sequence variants, and clinical outcomes. DNA methylation at nine (16%) CpG sites was associated with whole blood gene expression in cis (P < 8.47 × 10-5), ten (17%) CpG sites were associated with a nearby genetic variant (P < 2.50 × 10-3), and 51 (88%) were also associated with at least one related cardiometabolic entity (P < 9.58 × 10-5). An additive weighted score of replicated CpG sites accounted for up to 6% inter-individual variation (R2) of age-adjusted and sex-adjusted CRP, independent of known CRP-related genetic variants. CONCLUSION: We have completed an EWAS of chronic low-grade inflammation and identified many novel genetic loci underlying inflammation that may serve as targets for the development of novel therapeutic interventions for inflammation