15 research outputs found
Simple Preparation of New Potential Bioactive Nitrogen-Containing Molecules and Their Spectroscopy Analysis
Anti-leishmanial evaluation of C2-aryl quinolines: Mechanistic insight on bioenergetics and sterol biosynthetic pathway of Leishmania braziliensis
A series of diverse simple C2-aryl quinolines was synthesized de novo via a straightforward synthesis based on the acid-catalyzed multicomponent imino Diels–Alder reactions. Seven selected quinolines were evaluated at different stages of Leishmania braziliensis parasite. Among them, the 6-ethyl-2-phenylquinoline 5f was able to inhibit the growth of promastigotes of this parasite without affecting the mammalian cells viability and decreasing the number of intracellular L. braziliensis amastigotes on BMDM macrophages. The mechanism of action studied for the selected compound consisted in: (1) alteration of parasite bioenergetics, by disrupting mitochondrial electrochemical potential and alkalinisation of acidocalcisomes, and (2) inhibition of ergosterol biosynthetic pathway in promastigote forms. These results validate the efficiency of quinoline molecules as leishmanicide compounds.Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias5507-543-31904Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombianan
Democracia en la región andina
La oscilación violenta y frecuente entre regímenes democráticos y autoritarios caracterizó la historia latinoamericana hasta la década de 1980. Este patrón histórico fue al parecer superado luego de una serie de transiciones democráticas que probaron ser notablemente estables. Con el objetivo de contribuir a fortalecer la estabilidad democrática y de prevenir retrocesos hacia el autoritarismo, la Organización de Estados Americanos adoptó en 1991 una resolución que establecía la presencia de un régimen democráticos como condición para ser miembro de ella.
En este libro se presenta un diagnóstico comparado de las fortalezas y debilidades de la democracia en los países de la región, sobre la base de un enfoque integral respecto de las características del régimen político vigente en cada uno de ellos
Recomendaciones para mejorar la atención en enfermería
Nurse personnel performs a fundamental activity in health
services, with strong attach at scientific and ethical principles,
whose interventions can fortify the services of health quality,
through interdisciplinary actions.
We analyzed the compliants related to nursing attention
that were received in CONAMED since June 1996 to
December 2001. We devised recommendations directed
to prevent patient-health care professionals conflicts, improve
the practice of nursing and favor adequate communication
with the patient, family and interprofessional health care
team. Those recommendations were presented to the more
prestigious and recognized educational and professional
groups of nursing, for their external validation.
In this manner, CONAMED and the external group of
validation, propose to nurses to attend the following
recommendations: 1) Maintain an effective communication
with the patients that provides attention; 2) Recognize the
holistic concept in the person; 3) Provide cares that guarantee
free-risk attention and prevent unnecessary damages;
4) Establish an effective coordination with the health care
interprofessional team and 5) Act based on ethical principles
that govern the professional practice of nursing.El personal de enfermería desempeña una actividad fundamental
en los servicios de salud, con fuerte apego a principios
científicos y éticos, cuyas intervenciones permiten
fortalecer la calidad en los servicios de salud, a través de
acciones interdisciplinarias.
Se analizaron las inconformidades relacionadas con atención
de enfermería que recibió la CONAMED de junio de 1996
a diciembre de 2001, y se elaboraron recomendaciones dirigidas
a prevenir el conflicto, mejorar la práctica de enfermería
y propiciar la adecuada comunicación con el paciente, familiares
y equipo interprofesional de salud, que se presentaron a
las agrupaciones educativas y gremiales de enfermería más
prestigiadas y reconocidas, para su validación externa.
De esta manera, la CONAMED y el grupo de validación
externa, proponen al personal de enfermería atender las
siguientes recomendaciones: 1) Mantener una comunicación
efectiva con las personas a las que proporciona atención;
2) Reconocer en la persona su concepción holística;
3) Proporcionar cuidados que garanticen la atención libre
de riesgos y daños innecesarios; 4) Establecer una coordinación
efectiva con el equipo interprofesional de salud;
5) Actuar con base en los principios éticos que rigen la práctica
profesional de enfermería
How do energy balance-related behaviors cluster in adolescents?
BJECTIVES: To delineate the clustering of energy balance-related behaviors in adolescents and investigate whether these behaviors are associated with the household socioeconomic status and parental education level.
METHODS: Two cross-sectional studies assessed information on sedentary behavior, physical activity, sugar-sweetened beverages and fruit and vegetable consumption, and sleep duration by self-reported questionnaires in adolescents (12.5-17.5years old) from Maringa/Brazil (BRACAH Study; n=682) and ten European cities (HELENA Study; n=1252) from nine different countries. Gender-specific cluster analyses were performed separately for each study, applying a combination of hierarchical and non-hierarchical methods.
RESULTS: Girls showed equivalent behaviors: Sedentary; Active; Unhealthy Eating; Healthy Eating; while boys differed (Brazilian: Sedentary; Active; Healthy Eating; European: Sedentary; Healthy; Unhealthy Eating). In Brazil, we found no association between socioeconomic status and parental education. In European girls, the high socioeconomic status and both parents' university degree were associated with Healthy Eating. In European boys, the high socioeconomic status was associated with Unhealthy Eating, and the mothers' university degree was associated with the Healthy cluster.
CONCLUSIONS: Adolescents show Sedentary behavior, regardless of their sex, country of origin, or socioeconomic condition
Correlates of ideal cardiovascular health in European adolescents: The HELENA study
The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents.
METHODS AND RESULTS:
The study comprised 637 European adolescents with complete iCVH data. Participants were part of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional, multicenter study conducted in 9 different European countries. Correlates investigated were sex and age, family affluence scale, maternal education, geographic location, sleep time, television viewing, duration of pregnancy, birth weight and breastfeeding. Younger adolescents, those whose mothers had medium/high education or those who watched television less than 2 h per day had a greater number of iCVH components compared to those who were older, had a mother with low education or watched television 2 h or more daily (P ≤ 0.01).
CONCLUSION:
Since in our study older adolescents had worse iCVH than younger adolescents, early promotion of cardiovascular health may be important. Future studies may also investigate the usefulness of limiting television viewing to promote iCVH. Finally, since adolescents of mothers with low education had poorer iCVH, it may be of special interest to tailor public health promotion to adolescents from families with low socioeconomic status
Influence of parental socio-economic status on diet quality of European adolescents: Results from the HELENA study
3er. Coloquio: Fortalecimiento de los Colectivos de Docencia
Las memorias del 3er. Coloquio de Fortalecimiento de Colectivos de Docencia
deben ser entendidas como un esfuerzo colectivo de la comunidad de académicos de la División de Ciencias y Artes para el Diseño, en medio de la pandemia COVID-19, con el fin de:
• Analizar y proponer acciones concretas que promuevan el mejoramiento de la calidad docente en la División.
• Proponer acciones que permitan continuar fortaleciendo los cursos con modalidad a distancia (remotos).
• Ante un escenario que probablemente demandará en el mediano plazo, transitar del modelo remoto a un modelo híbrido, proponer acciones a considerar para la transición de los cursos.
• Planear y preparar cursos de nivelación de conocimientos, para cuando se transite a la impartición de la docencia de manera mixta o presencial, dirigidos a los alumnos que no hayan tenido oportunidad de desarrollar actividades relevantes para su formación, como prácticas de talleres y laboratorios, visitas, o alguna otra actividad relevante