Modeling of electrons and photons beams of linear (planar) accelerator Elekta Synergy in modelling system PLUNC

The article presents the experience of creating a model of beam in the non-commercial 3D Plan-UNC radiation treatment planning system (PLUNC). The results of dosimetry for electron and photon beams of the Elekta Synergy linear accelerator are presented

Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3

Cytochrome P450 ΒΜ-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively using atmospheric dioxygen as an oxidant. BM-3 variant 9-10A-A328V hydroxylates octane at the 2-position to form S-2-octanol (40% ee). Another variant, 1-12G, also hydroxylates alkanes larger than hexane primarily at the 2-position but forms R-2-alcohols (40−55% ee). These biocatalysts are highly active (rates up to 400 min-1) and support thousands of product turnovers. The regio- and enantioselectivities are retained in whole-cell biotransformations with Escherichia coli, where the engineered P450s can be expressed at high levels and the cofactor is supplied endogenously

X-ray lithographic alignment and overlay applied to double-gate MOSFET fabrication

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2003.Includes bibliographical references (leaves 117-118).Double-gate MOSFETs represent a significant solution to transistor scaling problems and promise a dramatic improvement in both performance and power consumption. In this work, a planar lithographic process is presented that is capable of producing double-gate MOSFET (DGFET) gate structures with 50 nm physical gate length and <5 nm alignment between upper and lower gates. Because a self-aligned approach is not taken, the central challenge in fabrication is to define each gate in separate lithographic steps with precision alignment of upper to lower-gate masks. In order to obtain optimum device performance, the position of the lower-gate should be aligned to the upper-gate to better than 10% of the gate length. The gates are defined using X-ray lithography (a close-proximity shadow printing scheme). The associated alignment scheme, Interferometric Broad Band Imaging (IBBI), has been proven to yield nanometer level sensitivity. While the IBBI alignment system offers superior alignment detectivity, it must be complemented by comparably successful mask pattern placement in order to yield structure details within the desired 5 nm tolerances. This work addresses the details of a novel mask design and fabrication scheme as well as its incorporation into the process flow of the DGFET. Additionally, the parasitic effects of strain that result from wafer bonding and thermal effects have been measured and analyzed.by Mitchell W. Meinhold.Ph.D

Aligned T-gate, fabrication using X-ray lithography

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (leaves 55-56).by Mitchell Meinhold.M.S

Technology Evaluation for Environmental Risk Mitigation Compendium

The Technology Evaluation for Environmental Risk Mitigation (TEERM) Principal Center and its predecessor organization the Acquisition Pollution Prevention Program (AP2) supported the National Aeronautics and Space Administration (NASA) in identifying technology solutions to risks and costs to NASA programs driven by environmental regulations and requirements. TEERM researched the commercial and government marketplace to locate viable and available technologies that met NASAs needs. TEERM focused on addressing environmentally-driven risks of direct concern to NASA programs and facilities, including hazardous materials in NASA operations and materials that became obsolescent because of environmental regulations. TEERM projects aimed to reduce cost; ensure the health and safety of people, assets, and the environment; promote efficiency; and minimize duplication. Major TEERM and AP2 projects focused on waste minimization and hazardous waste treatment, recycling, corrosion prevention and control, solvent and ozone depleting substances substitution, and aqueous based cleaners. In 2017, NASA made the decision to terminate the TEERM Principal Center. This Compendium Report documents TEERM and AP2 project successes. The Compendium Report traces the evolution of TEERM based on evolving risks and requirements for NASA and its relationship to the Space Shuttle Program, the United States Department of Defense, the European Space Agency, and other public and private stakeholders. This Compendium Report also documents project details from Project Summaries and Joint Test Plans and describes project stakeholders and collaborative effort results

The Impact of Atmospheric Fluctuations on Degree-scale Imaging of the Cosmic Microwave Background

Fluctuations in the brightness of the Earth's atmosphere originating from water vapor are an important source of noise for ground-based instruments attempting to measure anisotropy in the Cosmic Microwave Background. This paper presents a model for the atmospheric fluctuations and derives simple expressions to predict the contribution of the atmosphere to experimental measurements. Data from the South Pole and from the Atacama Desert in Chile, two of the driest places on Earth, are used to assess the level of fluctuations at each site.Comment: 29 pages, 7 figures, 1 table, appears in The Astrophysical Journa

Determination of Inflationary Observables by Cosmic Microwave Background Anisotropy Experiments

Inflation produces nearly Harrison-Zel'dovich scalar and tensor perturbation spectra which lead to anisotropy in the cosmic microwave background (CMB). The amplitudes and shapes of these spectra can be parametrized by $Q_S^2$, $r\equiv Q_T^2/Q_S^2$, $n_S$ and $n_T$ where $Q_S^2$ and $Q_T^2$ are the scalar and tensor contributions to the square of the CMB quadrupole and $n_S$ and $n_T$ are the power-lawspectral indices. Even if we restrict ourselves to information from angles greater than one third of a degree, three of these observables can be measured with some precision. The combination $130^{1-n_S}Q_S^2$ can be known to better than $\pm 0.3\%$. The scalar index $n_S$ can be determined to better than $\pm 0.02$. The ratio $r$ can be known to about $\pm 0.1$ for $n_S \simeq 1$ and slightly better for smaller $n_S$. The precision with which $n_T$ can be measured depends weakly on $n_S$ and strongly on $r$. For $n_S \simeq 1$ $n_T$ can be determined with a precision of about $\pm 0.056(1.5+r)/r$. A full-sky experiment with a $20'$beam using technology available today, similar to those being planned by several groups, can achieve the above precision. Good angular resolution is more important than high signal-to-noise ratio; for a given detector sensitivity and observing time a smaller beam provides significantly more information than a larger beam. The uncertainties in $n_S$ and $r$ are roughly proportional to the beam size. We briefly discuss the effects of uncertainty in the Hubble constant, baryon density, cosmological constant and ionization history.Comment: 28 pages of uuencoded postscript with 8 included figures. A postscript version is also available by anonymous ftp at ftp://astro.uchicago.edu/pub/astro/knox/fullsim.p