Early-time Spitzer observations of the type II-Plateau supernova, 2004dj

We present mid-infrared observations with the Spitzer Space Telescope of the nearby type II-P supernova, SN 2004dj, at epochs of 89 to 129 days. We have obtained the first mid-IR spectra of any supernova apart from SN 1987A. A prominent [NiII] 6.64 micron line is observed, from which we deduce that the mass of stable nickel must be at least 2.2e10(-4) Msun. We also observe the red wing of the CO-fundamental band. We relate our findings to possible progenitors and favour an evolved star, most likely a red supergiant, with a probable initial mass between ~10 and 15 Msun.Comment: ApJ Letters (accepted

The Rise Times of High and Low Redshift Type Ia Supernovae are Consistent

We present a self-consistent comparison of the rise times for low- and high-redshift Type Ia supernovae. Following previous studies, the early light curve is modeled using a t-squared law, which is then mated with a modified Leibundgut template light curve. The best-fit t-squared law is determined for ensemble samples of low- and high-redshift supernovae by fitting simultaneously for all light curve parameters for all supernovae in each sample. Our method fully accounts for the non-negligible covariance amongst the light curve fitting parameters, which previous analyses have neglected. Contrary to Riess et al. (1999), we find fair to good agreement between the rise times of the low- and high-redshift Type Ia supernovae. The uncertainty in the rise time of the high-redshift Type Ia supernovae is presently quite large (roughly +/- 1.2 days statistical), making any search for evidence of evolution based on a comparison of rise times premature. Furthermore, systematic effects on rise time determinations from the high-redshift observations, due to the form of the late-time light curve and the manner in which the light curves of these supernovae were sampled, can bias the high-redshift rise time determinations by up to +3.6/-1.9 days under extreme situations. The peak brightnesses - used for cosmology - do not suffer any significant bias, nor any significant increase in uncertainty.Comment: 18 pages, 4 figures, Accepted for publication in the Astronomical Journal. Also available at http://www.lbl.gov/~nugent/papers.html Typos were corrected and a few sentences were added for improved clarit

The dusty type IIn Supernova 1998S

The type IIn SN 1998S is one of the most remarkable core-collapse supernovae ever observed. It underwent a complex interaction with a substantial circumstellar medium, resulting in radiation at wavelengths from radio to X-rays. IR and optical observations have revealed a wide variety of broad and narrow emission lines. Examination of the SN/CSM interaction and of the ejecta spectra has allowed us to deduce that the supernova probably arose from a massive, RSG progenitor having a large (>3200 AU radius), dusty circumstellar disk. SN 1998S also developed one of the strongest, most persistent infrared excesses ever seen in a supernova. IR/optical monitoring of SN 1998S has been carried out to nearly 1200 days post-explosion. This includes coverage to wavelengths as long as 4.7 microns, making SN 1998S only the second supernova (after SN 1987A) to be observed in this spectral region. Fading of the central and redshifted components of the late-time H I and He I line profiles suggests strongly that dust condensed in the ejecta. However, it is less clear whether the strong late-time IR emission arose from this dust, or from an IR echo in the dusty CSM. One interesting possibility is that dust condensed in the cool dense shell between the outer and reverse shocks, thus simultaneously producing both the line obscuration and the IR emission.Comment: 9 pages. {Invited talk given at ESO/MPA/MPE Workshop "From Twilight to Highlight: The Physics of Supernovae", Garching, Germany, 29-31 July 2002. To appear in the Proceedings, eds. W. Hillebrandt & B. Leibundgut (pub. Springer-Verlag series ``ESO Astrophysics Symposia'

Abundances and density structure of the inner circumstellar ring around SN 1987A

We present optical spectroscopic data of the inner circumstellar ring around SN 1987A from the Anglo-Australian Telescope (AAT) and the Very Large Telescope (VLT) between ~1400 and ~5000 days post-explosion. We also assembled the available optical and near-infrared line fluxes from the literature between ~300 and ~2000 days. These line light curves were fitted with a photoionization model to determine the density structure and the elemental abundances for the inner ring. We found densities ranging from 1x10^3 to 3x10^4 atoms cm^-3 and a total mass of the ionized gas of ~0.058 Msun within the inner ring. Abundances inferred from the optical and near-infrared data were also complemented with estimates of Lundqvist & Fransson (1996) based on ultraviolet lines. This way we found an He/H-ratio (by number of atoms) of 0.17+-0.06 which is roughly 30% lower than previously estimated and twice the solar and the Large Magellanic Cloud (LMC) value. We found an N/O-ratio of 1.5+-0.7, and the total (C+N+O)/(H+He) abundance about 1.6 times its LMC value or roughly 0.6 times the most recent solar value. An iron abundance of 0.20+-0.11 times solar was found which is within the range of the estimates for the LMC. We also present late time (~5000 - 7500 days) line light curves of [O III], [Ne III], [Ne IV], [Ar III], [Ar IV], and [Fe VII] from observations with the VLT. We compared these with model fluxes and found that an additional 10^2 atoms cm^-3 component was required to explain the data of the highest ionization lines. Such low density gas is expected in the H II-region interior to the inner ring which likely extends also to larger radii at higher latitudes (out of the ring plane). At epochs later than ~5000 days our models underproduce the emission of most of these lines as expected due to the contribution from the interaction of the supernova ejecta with the ring.Comment: 17 pages, 8 figures, accepted for publication in Ap

On the Spectroscopic Diversity of Type Ia Supernovae

A comparison of the ratio of the depths of two absorption features in the spectra of TypeIa supernovae (SNe Ia) near the time of maximum brightness with the blueshift of the deep red Si II absorption feature 10 days after maximum shows that the spectroscopic diversity of SNe Ia is multi-dimensional. There is a substantial range of blueshifts at a given value of the depth ratio. We also find that the spectra of a sample of SNe Ia obtained a week before maximum brightness can be arranged in a ``blueshift sequence'' that mimics the time evolution of the pre-maximum-light spectra of an individual SN Ia, the well observed SN 1994D. Within the context of current SN Ia explosion models, we suggest that some of the SNe Ia in our sample were delayed-detonations while others were plain deflagrations.Comment: accepted for publication in ApJ

Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis

The early mechanisms regulating progression towards beta cell failure in type 1 diabetes (T1D) are poorly understood, but it is generally acknowledged that genetic and environmental components are involved. The metabolomic phenotype is sensitive to minor variations in both, and accordingly reflects changes that may lead to the development of T1D. We used two different extraction methods in combination with both liquid- and gas chromatographic techniques coupled to mass spectrometry to profile the metabolites in a transgenic non-diabetes prone C57BL/6 mouse expressing CD154 under the control of the rat insulin promoter (RIP) crossed into the immuno-deficient recombination-activating gene (RAG) knockout (−/−) C57BL/6 mouse, resembling the early stages of human T1D. We hypothesized that alterations in the metabolomic phenotype would characterize the early pathogenesis of T1D, thus metabolomic profiling could provide new insight to the development of T1D. Comparison of the metabolome of the RIP CD154 × RAG(−/−) mice to RAG(−/−) mice and C57BL/6 mice revealed alterations of >100 different lipids and metabolites in serum. Low lysophosphatidylcholine levels, accumulation of ceramides as well as methionine deficits were detected in the pre-type 1 diabetic mice. Additionally higher lysophosphatidylinositol levels and low phosphatidylglycerol levels where novel findings in the pre-type 1 diabetic mice. These observations suggest that metabolomic disturbances precede the onset of T1D. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11306-015-0889-1) contains supplementary material, which is available to authorized users

Spitzer measurements of atomic and molecular abundances in the Type IIP SN 2005af

We present results based on Spitzer Space Telescope mid-infrared (3.6-30 micron) observations of the nearby IIP supernova 2005af. We report the first ever detection of the SiO molecule in a Type IIP supernova. Together with the detection of the CO fundamental, this is an exciting finding as it may signal the onset of dust condensation in the ejecta. From a wealth of fine-structure lines we provide abundance estimates for stable Ni, Ar, and Ne which, via spectral synthesis, may be used to constrain nucleosynthesis models.Comment: ApJ Letters (accepted

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Aims/hypothesis: Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anaplerotic pathways, driving citrate export and cytosolic malonyl-CoA production by the acetyl-CoA carboxylase 1 (ACC1) enzyme. This pathway has been proposed as an alternative glucose-sensing mechanism, supported mainly by in vitro data. Here, we sought to address the role of the beta cell ACC1-coupled pathway in insulin secretion and glucose homeostasis in vivo. Methods: Acaca, encoding ACC1 (the principal ACC isoform in islets), was deleted in beta cells of mice using the Cre/loxP system. Acaca floxed mice were crossed with Ins2cre mice (βACC1KO; life-long beta cell gene deletion) or Pdx1creER mice (tmx-βACC1KO; inducible gene deletion in adult beta cells). Beta cell function was assessed using in vivo metabolic physiology and ex vivo islet experiments. Beta cell mass was analysed using histological techniques. Results: βACC1KO and tmx-βACC1KO mice were glucose intolerant and had defective insulin secretion in vivo. Isolated islet studies identified impaired insulin secretion from beta cells, independent of changes in the abundance of neutral lipids previously implicated as amplification signals. Pancreatic morphometry unexpectedly revealed reduced beta cell size in βACC1KO mice but not in tmx-βACC1KO mice, with decreased levels of proteins involved in the mechanistic target of rapamycin kinase (mTOR)-dependent protein translation pathway underpinning this effect. Conclusions/interpretation: Our study demonstrates that the beta cell ACC1-coupled pathway is critical for insulin secretion in vivo and ex vivo and that it is indispensable for glucose homeostasis. We further reveal a role for ACC1 in controlling beta cell growth prior to adulthood.</p