36 research outputs found

    Feasibility study of mitigation and suppression strategies for controlling COVID-19 outbreaks in London and Wuhan

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    Recent outbreaks of coronavirus disease 2019 (COVID-19) has led a global pandemic cross the world. Most countries took two main interventions: suppression like immediate lockdown cities at epicenter or mitigation that slows down but not stopping epidemic for reducing peak healthcare demand. Both strategies have their apparent merits and limitations; it becomes extremely hard to conduct one intervention as the most feasible way to all countries. Targeting at this problem, this paper conducted a feasibility study by defining a mathematical model named SEMCR, it extended traditional SEIR (Susceptible-Exposed-Infectious-Recovered) model by adding two key features: a direct connection between Exposed and Recovered populations, and separating infections into mild and critical cases. It defined parameters to classify two stages of COVID-19 control: active contain by isolation of cases and contacts, passive contain by suppression or mitigation. The model was fitted and evaluated with public dataset containing daily number of confirmed active cases including Wuhan and London during January 2020 and March 2020. The simulated results showed that 1) Immediate suppression taken in Wuhan significantly reduced the total exposed and infectious populations, but it has to be consistently maintained at least 90 days (by the middle of April 2020). Its success heavily relied on sufficiently external support from other places of China. This mode was not suitable to other countries that have no sufficient health resources. 2) In London, it is possible to take a hybrid intervention of suppression and mitigation for every 2 or 3 weeks over a longer period to balance the total infections and economic loss. While the total infectious populations in this scenario would be possibly 2 times than the one taking suppression, economic loss and recovery of London would be less affected. 3) Both in Wuhan and London cases, one important issue of fitting practical data was that there were a large portion (probably 62.9% in Wuhan) of self-recovered populations that were asymptomatic or mild symptomatic. These people might think they have been healthy at home and did not go to hospital for COVID-19 tests. Early release of intervention intensity potentially increased a risk of the second outbreak

    Enhancement strategies for transdermal drug delivery systems: current trends and applications

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    An exploratory study on the use of information sources by consumers to select Australian regional travel agencies

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    [Abstract]: This research investigates the information sources consumers used to select regional travel agencies to make their travel arrangements. The research design involves two stages, in-depth interviews with 13 participants and a mail-out survey of 400. The in-depth interviews highlighted the need to remove three particular information sources (travel guidebooks, travel or automotive clubs and local tourist offices) for inclusion in the mail-out survey and replaced with two other information sources (television lifestyle programs and travel consultants) worthy of investigation. The mail-out survey revealed that personal experience was the most important information source used in the selection of a regional travel agency whilst yellow pages were identified as the least influential. The findings highlighted the relative importance of the 11 information sources investigated and also suggested that informal sources were more important than formal sources when consumers search for information sources to assist them with their selection of the travel agencies to patronise
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