Coastal sea level response to the tropical cyclonic forcing in the northern Indian Ocean

The study examines the observed storm-generated sea level variation due to deep depression (event 1: E1) in the Arabian Sea from 26 November to 1 December 2011 and a cyclonic storm "THANE" (event 2: E2) over the Bay of Bengal during 25–31 December 2011. The sea level and surface meteorological measurements collected during these extreme events exhibit strong synoptic disturbances leading to storm surges of up to 43 cm on the west coast and 29 cm on the east coast of India due to E1 and E2. E1 generated sea level oscillations at the measuring stations on the west coast (Ratnagiri, Verem and Karwar) and east coast (Mandapam and Tuticorin) of India with significant energy bands centred at periods of 92, 43 and 23 min. The storm surge is a well-defined peak with a half-amplitude width of 20, 28 and 26 h at Ratnagiri, Verem and Karwar, respectively. However, on the east coast, the sea level oscillations during Thane were similar to those during calm period except for more energy in bands centred at periods of ~ 100, 42 and 24 min at Gopalpur, Gangavaram and Kakinada, respectively. The residual sea levels from tide gauge stations in Arabian Sea have been identified as Kelvin-type surges propagating northwards at a speed of ~ 6.5 m s−1 with a surge peak of almost constant amplitude. Multi-linear regression analysis shows that the local surface meteorological data (daily mean wind and atmospheric pressure) is able to account for ~ 57 and ~ 69% of daily mean sea level variability along the east and west coasts of India. The remaining part of the variability observed in the sea level may be attributed to local coastal currents and remote forcin

Status and future of global and regional ocean prediction systems

Operational evolution of global and regional ocean forecasting systems has been extremely significant in recent years. GODAE (Global Ocean Data Assimilation Experiment) Oceanview supports the national research groups providing them with coordination and sharing expertise among the partners. Several systems have been set up and developed pre-operationally and the majority of these are now fully operational; at the present time, they provide medium- and long-term forecasts of the most relevant ocean physical variables. These systems are based on ocean general circulation models (OGCMs) and data assimilation techniques that are able to correct the model with the information inferred from different types of observations. A few systems also incorporate a biogeochemical component coupled with the physical system while others are based on coupled ocean-wave-ice-atmosphere models. The products are routinely validated with observations in order to assess their quality. Data and products implementation and organization, as well as service for the users has been well tried and tested and most of the products are now available  to the users. The interaction with different users is an important factor in the development process. This paper provides a synthetic overview of the GODAE Oceanview prediction systems

Status and future of global and regional ocean prediction systems

Operational evolution of global and regional ocean forecasting systems has been extremely significant in recent years. GODAE (Global Ocean Data Assimilation Experiment) Oceanview supports the national research groups providing them with coordination and sharing expertise among the partners. Several systems have been set up and developed pre-operationally and the majority of these are now fully operational; at the present time, they provide medium- and long-term forecasts of the most relevant ocean physical variables. These systems are based on ocean general circulation models (OGCMs) and data assimilation techniques that are able to correct the model with the information inferred from different types of observations. A few systems also incorporate a biogeochemical component coupled with the physical system while others are based on coupled ocean-wave-ice-atmosphere models. The products are routinely validated with observations in order to assess their quality. Data and products implementation and organization, as well as service for the users has been well tried and tested and most of the products are now available  to the users. The interaction with different users is an important factor in the development process. This paper provides a synthetic overview of the GODAE Oceanview prediction systems.Publisheds201-s2204A. Clima e OceaniJCR Journalope

A review of Monte Carlo simulations of polymers with PERM

In this review, we describe applications of the pruned-enriched Rosenbluth method (PERM), a sequential Monte Carlo algorithm with resampling, to various problems in polymer physics. PERM produces samples according to any given prescribed weight distribution, by growing configurations step by step with controlled bias, and correcting "bad" configurations by "population control". The latter is implemented, in contrast to other population based algorithms like e.g. genetic algorithms, by depth-first recursion which avoids storing all members of the population at the same time in computer memory. The problems we discuss all concern single polymers (with one exception), but under various conditions: Homopolymers in good solvents and at the $\Theta$ point, semi-stiff polymers, polymers in confining geometries, stretched polymers undergoing a forced globule-linear transition, star polymers, bottle brushes, lattice animals as a model for randomly branched polymers, DNA melting, and finally -- as the only system at low temperatures, lattice heteropolymers as simple models for protein folding. PERM is for some of these problems the method of choice, but it can also fail. We discuss how to recognize when a result is reliable, and we discuss also some types of bias that can be crucial in guiding the growth into the right directions.Comment: 29 pages, 26 figures, to be published in J. Stat. Phys. (2011

Trapped and excited w modes of stars with a phase transition and R>=5M

The trapped $w$-modes of stars with a first order phase transition (a density discontinuity) are computed and the excitation of some of the modes of these stars by a perturbing shell is investigated. Attention is restricted to odd parity (``axial'') $w$-modes. With $R$ the radius of the star, $M$ its mass, $R_{i}$ the radius of the inner core and $M_{i}$ the mass of such core, it is shown that stars with $R/M\geq 5$ can have several trapped $w$-modes, as long as $R_{i}/M_{i}<2.6$. Excitation of the least damped $w$-mode is confirmed for a few models. All of these stars can only exist however, for values of the ratio between the densities of the two phases, greater than $\sim 46$. We also show that stars with a phase transition and a given value of $R/M$ can have far more trapped modes than a homogeneous single density star with the same value of $R/M$, provided both $R/M$ and $R_{i}/M_{i}$ are smaller than 3. If the phase transition is very fast, most of the stars with trapped modes are unstable to radial oscillations. We compute the time of instability, and find it to be comparable to the damping of the $w$-mode excited in most cases where $w$-mode excitation is likely. If on the other hand the phase transition is slow, all the stars are stable to radial oscillations.Comment: To appear in Physical Review

Template-stripped gold surfaces with 0.4 nm rms roughness suitable for force measurements. Application to the Casimir force in the 20-100 nm range

Using a template-stripping method, macroscopic gold surfaces with root-mean-square (rms) roughness less than 0.4 nm have been prepared, making them useful for studies of surface interactions in the nanometer range. The utility of such substrates is demonstrated by measurements of the Casimir force at surface separations between 20 and 100 nm, resulting in good agreement with theory. The significance and quantification of this agreement is addressed, as well as some methodological aspects regarding the measurement of the Casimir force with high accuracy.Comment: 7 figure

IRAK4 gene polymorphism and odontogenic maxillary sinusitis

Objectives This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin.Materials and methods The study population included 153 Portuguese Caucasians that were selected from a database of 504 retrospectively analysed computed tomography (CT) scans. A genetic test was performed, and a model was created through logistic analysis and regression coefficients. The statistical methodologies included were the independent Chi test, Fisher's exact test, binary logistic regression and the receiver operating characteristic (ROC) curve.Results The estimated prevalence of IRAK4 gene polymorphism found in a Portuguese Caucasian population was 26.8 % (CI 95 %) [20.1, 34.7 %]. A model to predict the inflammatory response in the maxillary sinus in the presence etiological factors of dental origin was constructed. This model had the following as variables: previously diagnosed sinusitis, sinus pressure symptoms, cortical bone loss observed on CT, positive genetic test result and radiographic examination that revealed the roots of the teeth communication with the maxillary sinus, which are interpreted as risk factors.Conclusions The constructed model should be considered an initial clinical tool. The area under the ROC curve found, AUC=0.91, revealed that the model correctly predicts the outcome in 91.1 % of cases.info:eu-repo/semantics/publishedVersio

Important pharmacogenetic information for drugs prescribed during the SARS-CoV-2 infection (COVID-19)

In December 2019, the severe acute respiratory syndrome virus-2 pandemic began, causing the coronavirus disease 2019. A vast variety of drugs is being used off-label as potential therapies. Many of the repurposed drugs have clinical pharmacogenetic guidelines available with therapeutic recommendations when prescribed as indicated on the drug label. The aim of this review is to provide a comprehensive summary of pharmacogenetic biomarkers available for these drugs, which may help to prescribe them more safelyM.N.-G. is co-financed by the European Social Fund and the Youth European Initiative; grant number PEJ-2018-TL/BMD-1108