In-vitro synergistic effect of fluconazole with nonsteroidal anti-inflammatory agents against Candida albicans strains

The in-vitro interaction and synergistic activity of the combination of fluconazole with some nonsteroidal anti-inflammatory drugs (sodium salicylate, piroxicam, tenoxicam and diclofenac sodium) were investigated in Candida albicans strains (n = 7) by the microdilution checkerboard assay. The results were evaluated visually and by a spectrophotometric microplate reader at 492 nm wavelength. Fractional inhibitory index was calculated for every strain and combination according to the minimal inhibitory concentration (MICs). The combination of fluconazole with sodium salicylate, tenoxicam and diclofenac sodium showed synergy against 5, 5 and 3 of the C. albicans strains, respectively. The effect of fluconazole with piroxicam was synergistic against one strain but indifferent/additive against the others. These data suggest that combinations of sodium salicylate, tenoxicam and diclofenac sodium with fluconazole may prove to be useful as chemotherapeutic agents for the treatment of C. albicans infections caused by especially fluconazole-resistant strains. However, additional preclinical work and in vivo studies are necessary to determine their definite clinical use

Evaluation Of Pregnancies In 25 Families With Balanced/Unbalanced Chromosomal Translocations

The researchers evaluated pregnancies in families with balanced/unbalanced translocations. This clinical cohort consisted of 25 pregnancies with balanced/unbalanced chromosomal translocations in family member(s) (maternal, paternal, fetal, abortion material, and/or previous fetus(es)) who underwent prenatal diagnosis. Translocations were observed in 18 cases (14 balanced and 4 unbalanced translocations). The researchers found 2 and 12 cases among the chromosomal translocations were paternal and maternal in origin, respectively. The researchers demonstrated that parent karyotypes were normal in 4 cases, while only maternal karyotypes were normal in 3 cases with unknown paternal karyotypes. Five of the prenatally diagnosed chromosomal abnormalities were Robertsonian and 13 were reciprocal translocations, Among the Robertsonian translocations, 2 were unbalanced. Early fetal loss or recurrent miscarriages were observed in previous history of 10(40%) and 6(24%) respectively. Prenatal diagnosis is critical in pregnancies with balanced/unbalanced chromosomal translocations in a member(s) of the family or those with poor gestational histories.Wo

Advanced oxidation protein products - A novel marker of oxidative stress in ulcerative colitis

Background/Goals: The etiology and pathogenesis of chronic inflammatory bowel diseases are still poorly understood. Oxidative stress takes place in the pathogenesis of ulcerative colitis (UC) and advanced oxidation protein products (AOPP) are accepted as a novel marker of oxidative stress. There are no data concerning whether AOPP may be used as a simple serum marker to assess the disease activity, predict severity of the disease course in UC

ACUTE ADRENOCORTICAL FAILURE DUE TO TUBERCULOSIS

A 55-year-old woman presented with acute adrenal failure, active pulmonary tuberculosis and an enlarged adrenal mass which was subsequently removed surgically. Histopathologic examination disclosed adrenal tuberculoma. It was concluded that tuberculosis might result not only in chronic adrenocortical insufficiency but also in acute adrenal failure

Serum paraoxonase 1 activity and malondialdehyde levels in patients with ulcerative colitis

This study was designed to evaluate the oxidative and antioxidative status in patients with ulcerative colitis by detecting antioxidant enzyme paraoxonase I activity together with the level of a well-known marker of oxidative stress, malondialdehvde. Serum paraoxonase 1 activity and malondialdehyde levels were analysed in 30 patients with ulcerative colitis and 30 controls using a spectrophotometric method; correlation analysis was made between these variables. Serum malondialdehyde levels were higher in the ulcerative colitis group (median: 2.5, range: 0.5-9.4 nmol ml(-1)) than among the controls (median:1.1. range: 0.5-2.3 nmol/ml(-1); p < 0.001) whereas paraoxonase I activities were lower in the ulcerative colitis group (median: 158.4, range: 61.6 -264.1Ul(-1)) than in the control group (median: 233.3, range: 114.4-431.0 Ul(-1); p < 0.001). There was no correlation between serum malondialdehyde level, paraoxonase 1 activity and disease activity. (1) Increased reactive oxygen metabolites levels in ulcerative colitis may result in a pro-oxidation environment, which in turn could result in decreased antioxidant paraoxonase 1 activity and increased malondialdehyde levels, (2) increased cytokines may be a possible cause of decreased paraoxonase 1 activity and (3) decreased serum paraoxonase 1 activity may be a part of an inflammatory response. Copyright (c) 2005 John Wiley & Sons, Ltd

Prolonged cholestatic jaundice associated with flurbiprofen

© The Author(s) 2013.Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed drugs throughout the world for pain relief. Although the adverse effects of NSAIDs to the liver are well known, flurbiprofen-induced liver cholestasis is extremely rare. Herein, we present a patient with prolonged icterus that is associated with the use of flurbiprofen without causing ductopenia