Investigating the growth kinetics of gram-positive and gram-negative bacteria in the presence of zinc oxide nanoparticles and curcumin Çinko oksit nanopartiküller ve kurkumin varlığında gram pozitif ve gram negatif bakterilerin büyüme kinetiğinin incelenmesi

xiv, 44 sayfa29 cm. 1 CDAntimikrobiyal direnç, Dünya Sağlık Örgütü'ne (DSÖ) göre önde gelen küresel sağlık sorunlarından birisidir. Antibiyotiklerin bilinçsiz ve fazla kullanımı, dirençli mikroorganizma türlerinin oluşmasına neden olmuştur. Antibiyotiklerin dirençli suşlara karşı etkinliğinin düşük olması nedeniyle araştırmalar geleneksel antibiyotiklerin yerine geçebilecek alternatif yaklaşımlara yönelmiştir. Nanotıbbın hızlı gelişimi ile birlikte, araştırmacılar nanopartikülleri kullanarak çözümler üretmeyi amaçlamışlardır. Metal oksit nanoparçacıklar, yüksek stabilite ve mikroorganizmalara karşı gösterdiği çoklu etki nedeniyle öne çıkmaktadırlar. Bunların en öne çıkanlarından biri çinko oksit nanoparçacıklardır (ZnO NP).ABSTRACTAntimicrobial resistance is one of the leading global health threats for human health according to World Health Organization (WHO). The excess or misuse of antibiotics to combat microorganisms causes the generation of a resistant strain of microorganisms. Because of the low efficiency of antibiotics against resistant strains, researchers have leaned to alternative approaches despite conventional antibiotics. With the rapid development of nanomedicine, diverse approaches were investigated to solve antimicrobial resistance problems using nanoparticles. Metal oxide nanoparticles with their high stability and multi-action mechanisms against microorganisms make them efficient for antimicrobial therapy. One of the most outstanding metal oxide nanoparticles is zinc oxide nanoparticles (ZnO NPs)

Synthesis and crystal structure of a chiral lactam and three amino alcohols as potential protein tyrosine phosphates 1B inhibitors

Chiral lactam 2 and three chiral 3-amino alcohols 3-5 have been synthesized and characterized by Sspectroscopic techniques. Regioselective ring opening reaction of chiral styrene oxide by an amine nucle-ophile was confirmed by X-ray diffraction data. Ligand 2-4 crystallizes in the tetragonal, orthorhombic and tetragonal crystal lattice system respectively. Ligands 2-6 have been used as potential inhibitors for protein tyrosine phosphatase 1B enzyme (PTP1B). The potential inhibitor effect of these molecules to the target protein was investigated by Dock and molecular dynamics calculations. Dock score analysis and Lipinski parameters suggested that ligands 1,2,4-6 are potential inhibitors towards PTP1B, thus indicating that the residues Arg24, Arg254 and Met258, Asp29 in the second active site of PTP1B are essential for the high selectivity of inhibitors. The results indicate that the polar hydrogen bonding interacts with Asp29, Gln102, and the amino acid residues of PTP1B are responsible for governing inhibitory potency of ligands 1-6. (C) 2017 Elsevier Ltd. All rights reserved

Pseudoaneurysm discovered during reverse radial forearm flap after a gunshot injury: a case report

Gunshots cause injury on the vascular wall by phsical forces and thermal effect. These injuries are minor intimal damage, complete or partial transaction of the vessel, arteriovenoous fistula and pseudoaneurysm. In this article we report a pseudoaneursym case, at a gunshot wound on right hand planned to repair by reverse radial forearm flap for to cover the defect occured at the ipsilateral dorsum of the right hand, which was suspected on CT angiography but missed out preoperatively and seen in surgery during exploration and reparied. [Med-Science 2013; 2(1.000): 414-22

Soil improvement to counter liquefaction using colloidal silica grout injection

Soil liquefaction due to earthquakes is a major reason of damage to buildings and other structures. This study deals with soil improvement against liquefaction by injection of a particular stabiliser, colloidal silica, which is nontoxic and stable. Laboratory experiments were performed to determine the effects of colloidal silica grout injection regarding soil strength and deformations. The experiments involved static and dynamic triaxial tests on untreated and treated soil samples. The variables used in the tests are the relative density (loose - 40%, medium - 60% and dense - 80%), the confining pressure (100 and 300 kPa), and the curing period of silica treated samples (7 and 28 days). The results clearly indicate the significant increase in strength of the soil with colloidal silica injection. Furthermore, the relative increase is the highest in the sand of the lowest relative density which is the most probable candidate for soil improvement. The observations that the increase in the strength of colloidal silica treated sands with curing time is gradual and continuous add to the advantage of this method for use in soil improvement works. By using the dynamic test results, the equivalent Young modulus (or shear modulus) and the hysteretic damping ratio of untreated and treated soils are compared. © 2019, Scibulcom Ltd. All rights Reserved

Synthesis of canthaxanthin from β-carotene and evaluation of both substances in diode construction

© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.First, canthaxanthin was synthesized from β-carotene, and it was confirmed by its FTIR spectrum that the synthesized substance was canthaxanthin. Then, three different diodes (Al/β-carotene/n-Si, Al/canthaxanthin/n-Si, and Al/canthaxanthin/p-Si) were made using these substances for interface layer. The current–voltage curves of the diodes were determined both in the dark and under an illumination of 100 mW/cm2 at 300 K. The ideality factors, barrier heights, and series resistances of the diodes in the dark and 300 K were calculated according to Bethe’s thermionic emission (TE) theory, Norde function, and Cheung and Cheung method. Then, the effect of temperature on the current–voltage curves of the diodes was investigated. The ideality factors and barrier heights of the diodes at these temperatures were calculated only according to the TE theory. Finally, the effect of frequency on the capacitance–voltage and conductance-voltage curves of the diodes was investigated

Complexation and transport of amino acid esters and their salts with synthesised chiral novel aza crown ether derivatives

<div><p>The syntheses of four aza-15-crown-5 ethers bearing phenyl and phenoxymethyl moieties attached to a stereogenic centre on the crown ring were achieved. Macrocycles have exhibited strong binding ability (<i>K</i>_a = 5364–12,969 M^− 1) and modest enantiomeric discrimination towards the enantiomers of amino acid methyl ester salts by UV titration method in CHCl₃ at 25°C. Computer modelling results supported experimental data providing a detailed understanding of the molecular recognition mode between hosts and guests and the likely binding sites involved. Macrocycles were used for chiral discrimination of amino acids in their zwitterionic forms or as potassium and sodium salts in transport experiments across a bulk chloroform membrane with satisfactory selectivity.</p></div

Fat Embolism Syndrome in Two Cases with Multiple Fractures

Fat embolism is a syndrome which is caused by oil particles introduce into the systemic circulation and consists of respiratory distress, altered consciousness and petechial rashes. It may occur following traumatic, surgical and non-traumatic clinical conditions. The most common occurrence develops following the long bone fractures within 24-72 hours. The clinical picture of syndrome may vary slightly condition as well as respiratory failure and coma. The diagnosis is done based on mostly clinical criteria. There is no specific laboratory and radiographic findings. The suggested supportive approaches in the treatment of this syndrome are early fixation of the fracture, maintenance of fluid and electrolyte balance and treatment of hypoxia. We aimed to present two cases of successful diagnosis and treatment process with fat embolism syndrome following multiple fractures due to in-vehicle traffic accidents. (Journal of the Turkish Society Intensive Care 2012; 10: 23-7

The Amputation Endicated Extremity Can Be Recovered by Multidisciplinary Treatment: A Case Report and Review of Literature [Multidisipliner Yaklasimla Amputasyon Endikasyonu Olan Ekstremite Kurtarilabilir: Olgu Sunumu ve Literatur Derlemesi]

With the development of microsurgical techniques and successfull multidisciplinary approach; many injuries that requires amputation can be treated successfully by extremity preventing surgery. We present a case that admitted to our clinic with open fracture and although had amputation endication, treated with extremity reconstruction surgery. [Med-Science 2015; 4(2.000): 2281-8