Foramen Scapulae Osseum

We determined that anomaly of foramen scapula osseum on a skeleton of left scapula which has been in Department of Anatomy in Medical Faculty of Dicle University. Incisura scapulae, just medial to the basis of the coracoid process, we observed that the superior transverse scapular ligament ossifies, resulting in a complete osseous passage which is named foramen scapula osseum. A very narrow scapular foramen can produce a complete peripheral compression syndrome of the suprascapular nerve (paresis of supraspinatus and infraspinatus muscles). That variation may an important role for determining in paresis of suprascapular nerve

Resveratrol showed anti-inflammatory effects on hippocampus via suppressing NFκB

Background: Traumatic brain injury (TBI) is the damage to the brain caused by external blow or jolt to the head or body. TBI secondarily induces cell damage in the hippocampus. This study aimed to investigate effects of resveratrol treatment histological examination and nuclear factor kappa B (NFκB) expression in hippocampus after TBI. Materials and methods: Twenty-four rats were assigned to three groups: sham, TBI and TBI+Resveratol. TBI was conducted by dropping a 50-g weight from a 1-meter height from a tube to the head of animals. 20 mg/kg resveratrol was orally administered to rats after TBI. Blood was collected to measure malondialdehyde (MDA) and glutathione (GSH) contents. Cerebral tissues were processed for histopathology and furtherly for immunohistochemical analysis. Results: MDA content was significantly increased and GSH value were significantly decreased in TBI group compared to sham group. Resveratrol treatment significantly improved biochemical scores in TBI+Resveratrol group. Normal histological appearance was observed in hippocampal sections of sham group. In TBI group, neurons in hippocampus were degenerated. Their nuclei were pyknotic. Other neurons and supportive neuroglial cells in hippocampal proper and dentate gyrus were also disrupted. Hippocampal proper integrity was lost with vascular dilatation. NFκB was upregulated in hippocampal neurons of TBI group. Conclusions: Resveratrol treatment alleviated pathologies and downregulated NFκB expression in hippocampus. TBI caused adverse alterations in free radicals’ balance system and histological structures of hippocampus. Resveratrol with its antioxidant and anti-inflammatory effects reduced the damage caused by TBI

Scanning electron microscopy assessment of the load-bearing capacity of cad/cam-fabricated molar crowns

Although fiber-reinforced composites are commonly used in dental practice, whether fiber-reinforced crowns and fixed partial dentures can be used as definitive prostheses remains to be determined. This study used scanning electron microscopy to evaluate the load-bearing capacity of non-reinforced and fiber-reinforced composite (FRC) molar crowns prepared by computer-aided design/computer-aided manufacturing (CAD/CAM). The crowns were fabricated from three empirical FRC blocks, one empirical composite block, and one commercial ceramic block. The FRC resin was prepared by mixing BaO silicate particles, E-glass fiber, and dimethacrylate resin. Specimens were divided into five groups (n = 10), differing in the amounts of filler, resin, and fiber. Crowns were statically loaded until fracture. One-way analysis of variance and Tukey’s post hoc multiple comparison tests were used for statistical analyses. The groups showed significant differences in load-bearing capacity; empirical bidirectional FRC resin blocks had the highest capacity, while commercial ceramic blocks had the lowest capacity. Molar crowns formed from FRC resin blocks had higher load-bearing capacity compared to non-reinforced composite resin and ceramic blocks. These results show that fiber reinforcement increased the load-bearing capacity of molar crowns</p

Evaluation of the effects of Momordica charantia on tibial defect injury in rats

We aimed to examine the histological and immunohistochemical effects of Momordica charantia on bone repair, which provides positive regulation such as blood sugar, blood pressure, antilipidemic, anticarcinogenic, antibacterial, antioxidant, anti-inflammatory, wound healing, and tissue regeneration in rats with tibial bone defect. Momordica charantia (MC) (commonly called bitter melon; Goya; bitter apple; bitter gourd; bitter squash; balsam-pear; with many more names listed below) is a tropical and subtropical vine of the family Cucurbitaceae, widely grown in Asia, Africa, and the Caribbean for its edible fruit. Its many varieties differ substantially in the shape and bitterness of the fruit. &nbsp;In this study, 32 male Sprague Dawley rats, 12 weeks old and weighing 250-300gr, were used. 8 rats in each group randomly, 1st group control, 2nd group defect (Sham), 3rd group defect + MC group (14 days), 4th group defect + MC group (28 days) separated into the group. In this experimental study, 600 mg/kg/day MC (bitter melon) extract was mixed into the drinking water of groups 3 and 4 and administered to rats by oral tube. One 6 mm diameter cylindrical defects were created in the body of the right tibia bone. No action was taken in Group 1. In Group 2, only tibial defect was made. For 14 days in group 3 and 28 days in group 4, 600 mg/kg/day MC extract was mixed with drinking water and given by oral gavage. Elevated Malondialdehyde (MDA) levels and Myeloperoxidase (MPO) decreased. In groups 3 and 4, osteoblastic activity and osteocyte development increased, while osteopontin and osteonectin expression were found to be positive, while osteoclastic activity decreased compared to the sham group. It is a good antioxidant in the groups where MC is applied. It has been observed that it can have a positive effect on bone repair. Keywords: Momordica charantia; Tibial defect; Fracture healing; Bone repair; Antioxidan

Investigation of the Effect of Quercetin in Experimental Ischemia-Reperfusion Injury Model in Rat Testicle

Testicular torsion (TT) is the most important cause of acute scrotum in childhood. It is an emergency surgical problem that can lead to loss of organ if left untreated. The aim of treatment is to reduce or eliminate the torsion/detorsion damage. The affect of antioxidants is one of the methods to be used for this reason. In this study, a special bioflavonoid and quercetin, an antioxidant known to protect against oxidative damage, were used to avoid experimentally caused torsion/detorsion damage in rats. 32 male Sprague Dawley rats, 12 weeks old, weighing 250–300 g, were used in the study.Rats were randomized into 4 groups. No surgical procedure was performed in the control group. 5-hour ischemia was achived by applying torsion to the left testicle in the torsion group. After 5 hours of ischemia, a 2-hour reperfusion was applied in the torsion/detorsion group. In the torsion/detorsion+quercetin group, 2 hours of reperfusion was applied after 5 hours of ischemia and i.p. quercetin was injected. &nbsp;A significant decrease was observed in the quercetin-administered group in terms of spermatocyte degeneration and inflamation. There was a decrease in dilatation data in the quercetin group, but it was not statistically significant. Quercetin, which has a strong antioxidant effect, has been shown to have positive effects on experimentally induced torsion/detorsion damage. Keywords: Testicular torsion, ischemia-reperfusion, antioxidan, quercetin, Inflammation&nbsp

The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats

H, Ozturk/0000-0001-5608-5742; Tuncer, Mehmet Cudi/0000-0001-7317-5467;WOS: 000263508000016PubMed: 18787973This study was designed to determine the effect of molsidomine (MO), a precursor of nitric oxide (NO) donor, on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of testes ischemia/reperfusion (I-R) injury. Torsions were created by rotating ipsilateral testes 720A degrees in a clockwise direction for 6 h and 1-h detorsion of the testis was performed. A sham operation was performed in group 1 (control, n = 7). In group 2 (I-R/Untreated, n = 7), following 6 h of unilateral testicular torsion, 1-h detorsion of the testis was performed. No drug was given. In group 3 (I-R/MO), after performing the same surgical procedure as in group 2, a NO donor MO was given at the starting time of reperfusion. In group 4 (I-R/L-NAME), after performing the same surgical procedure as in group 2, L-NAME was given at the starting time of reperfusion. Testes malondialdehyde (MDA) levels were determined as well as examining the testes histologically. Treatment of rats with MO produced a significant reduction in the levels of MDA and histopathological score compared to testes I-R groups. The Sonic hedgehog (Shh) expression in the basement membrane of the tubuli seminiferi, and sertoli and germinal cells in testicular tissue, were greatly increased in the I-R/MO group compared to groups 1, 2 and 4. Additionally, the HIF-1 alpha expression in the interstitial spaces in testicular tissue were greatly increased in the I-R/MO group. The results suggest that MO has a protective effect against ischemia/reperfusion injury in rat testes and may affect Shh and HIF-1 alpha signaling pathway

Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study

In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200-250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue