Pediatric Kennedy Terminal Ulcer

Photograph of Fossett's circus loads, 2 AEC Matadors - KKN412 - and trailers, taken Forest site, 28 September 1959 whole side view

An exploration of the aspects of physical activity and exercise motives that confer risk versus protection from disordered eating outcomes

A long-standing health initiative has been the recommendation for individuals to engage in regular physical activity because of its numerous physical and mental health benefits. However, engaging in “excessive exercise” is a compensatory behavior found in eating disorders. The present study sought to better understand exercise as both a health- and risk-behavior. Undergraduates (N = 1010) completed an online survey assessing disordered eating and exercise behavior. Results revealed that among individuals who engaged in a low level of physical activity, exercising for socializing reasons conferred risk for disordered eating, whereas higher socializing exercise motives were associated with lower disordered eating behavior. Findings suggest that it may be particularly useful to know how often individuals engage in exercise when they have high socializing motives. Future research should examine the Exercise Benefits/Barriers Scale (EBBS) to investigate individuals’ simultaneous reasons for engaging in exercise and barriers to participating in exercise

Experiential learning as preparation for leadership: an exploration of the cognitive and physiological processes

Purpose: The objective of the study was to explore whether challenging experiences on development programmes would simulate leadership challenges and therefore stimulate the body’s autonomic nervous system response. We also aimed to determine whether increase in autonomic arousal would be related to learning, and/or moderated by personality variables. Design/methodology/approach: The research used heart rate monitors to measure heart rate continuously over a two-day simulated learning experience. This was used to calculate autonomic arousal which was taken to be the difference between resting heart rate measured during sleep (HR) and HR during critical incidents (ΔHR). We correlated this with self-reports of learning immediately after, and one month after, the programme to assess the impact of autonomic arousal on perceived learning, as well as with variety of psychometric measures. Findings: The research found significant correlations between (ΔHR) during critical incidents and perceived learning which were not related to personality type. The research also found a significant correlation between (ΔHR) and learning during a control event for individuals with ‘approach’ personalities. Research limitations/implications: Whilst a significant result was found, the sample size of 28 was small. The research also did not empirically assess the valence or intensity of the emotions experienced, and used only a self-report measure of learning. Future research should replicate the findings with a larger sample size, attempt to measure these emotional dimensions, as well as obtain perceptions of learning from direct reports and line managers. Practical implications: The findings from the research help clarify the mechanisms involved in the effectiveness of experiential learning, and contribute to our understanding of the influence of personality type on perceived learning from experiential methodologies. Such understanding has implications for Business Schools and learning and development professionals, suggesting that development experiences that challenge leaders are likely to result in learning that is longer-lasting. Originality/value: The research extends the literature regarding the value of learning through experience, the role of autonomic arousal on learning, and the impact of negative emotions on cognition. The research makes a unique contribution by exploring the impact of experience on arousal and learning in a simulated learning experience and over time, by demonstrating that simulated experiences induce emotional and physiological responses, and that these experiences are associated with increased learning

Testing the temporal ability of landsat imagery and precision agriculture technology to provide high resolution historical estimates of wheat yield at the farm scale

The long term archiving of both Landsat imagery and wheat yield mapping datasets sensed by precision agriculture technology has the potential through the development of statistical relationships to predict high resolution estimates of wheat yield over large areas for multiple seasons. Quantifying past yield performance over different growing seasons can inform agricultural management decisions ranging from fertilizer applications at the sub-paddock scale to changes in land use at a landscape scale. However, an understanding of the magnitude of prediction errors is needed. In this study, we examine the predictive wheat yield relationships developed from Normalised Difference Vegetation Index (NDVI) acquired Landsat imagery and combine-mounted yield monitors for three Western Australian farms over different growing seasons. We further analysed their predictive capability when these relationships are used to extrapolate yield from one farm to another. Over all seasons, the best predictions were achieved with imagery acquired in September. Of the five seasons reviewed, three showed very reasonable prediction accuracies, with the low and high rainfall years providing good predictions. Medium rainfall years showed the greatest variation in prediction accuracy with marginal to poor predictions resulting from narrow ranges of measured wheat yield and NDVI values. These results demonstrate the potential benefit of fusing together two high resolution datasets to create robust wheat yield prediction models over different growing seasons, the outputs of which can be used to inform agricultural decision making.Greg Lyle, Megan Lewis and Bertram Ostendor

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants

INTRODUCTION: There is increasing interest in plasma amyloid beta (Aβ) as an endophenotype of Alzheimer's disease (AD). Identifying the genetic determinants of plasma Aβ levels may elucidate important biological processes that determine plasma Aβ measures. METHODS: We included 12,369 non-demented participants from eight population-based studies. Imputed genetic data and measured plasma Aβ1-40, Aβ1-42 levels and Aβ1-42/Aβ1-40 ratio were used to perform genome-wide association studies, and gene-based and pathway analyses. Significant variants and genes were followed up for their association with brain positron emission tomography Aβ deposition and AD risk. RESULTS: Single-variant analysis identified associations with apolipoprotein E (APOE) for Aβ1-42 and Aβ1-42/Aβ1-40 ratio, and BACE1 for Aβ1-40. Gene-based analysis of Aβ1-40 additionally identified associations for APP, PSEN2, CCK, and ZNF397. There was suggestive evidence for interaction between a BACE1 variant and APOE ε4 on brain Aβ deposition. DISCUSSION: Identification of variants near/in known major Aβ-processing genes strengthens the relevance of plasma-Aβ levels as an endophenotype of AD

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development

How does Martin Buber's concept of I-Thou dialogue inform the theory and practice of relational leadership?

This thesis explores the possibility of dialogue between leader and follower in order to further develop the theory and practice of relational leadership. It draws from and contributes to Relational Leadership Theory (Uhl-Bien 2006) and Buber’s concept of ‘I- Thou’ dialogue (Buber 1958). Using first-person and co-operative inquiry methods (Reason and Bradbury 2008b) the ‘space between’ (Bradbury and Lichtenstein 2000, Buber 1958) leader and follower is explored in order to reveal the complexities inherent within leadership relations. Four main findings are detailed which enrich our understanding of how leadership relations operate from ‘within living involvement’ (Shotter 2006). Firstly, the quality of leader-follower encounter could be affected by levels of ‘busyness’ and the ensuing assessment and prioritising process. Secondly, the pressure to ‘seem’ rather than ‘be’ may strengthen the construction of a façade which might be dismantled, in part, through disclosure, though this may feel extremely risky given organisational ‘rules’. Thirdly, mutuality between leader and follower may be crucially influenced by the way in which ‘leader’, ‘leadership’ and ‘power’ are constructed in the between space. Finally, ineffable dialogic moments may occur through sensing a particular quality of encounter amidst and despite the complexity of a myriad of micro-processes vying for attention in the between space. This thesis contributes a further strand to RLT constructionist work focused on the quality of leader-follower encounter which has not been previously revealed. Leadership constructs and macro-discourses relating to power, ‘busyness’ and the need for ‘worthwhile meetings’ encourages transactional relating. Consequently, opportunities for genuinely encountering others in organisational settings are suffocated. This holds important implications for ‘leaders’ and ‘followers’ who wish to creatively address pressing organisational issues in the 21st century through dialogue. Fundamentally this thesis suggests we pause to consider the implications that the nature of our encounters in our work-life have upon us as human beings wishing to know what it is to be fully human