Clearing Safe Spaces for Drought Affected Communities in Somaliland

Governments and nongovernmental organizations (NGO) working in the Horn of Africa consistently identify conflict and climate change as two primary drivers of insecurity in the region. The HALO Trust’s landmine and explosive remnants of war (ERW) clearance in the Republic of Somaliland over the last 19 years has been at the intersection of these two issues

The Border of Lights Reader

Border of Lights, a volunteer collective, returns each October to Dominican-Haitian border towns to bear witness to the 1937 Haitian Massacre ordered by Dominican dictator Rafael Leónidas Trujillo. This crime against humanity has never been acknowledged by the Dominican government and no memorial exists for its victims. A multimodal, multi-vocal space for activists, artists, scholars, and others connected to the BOL movement, The Border of Lights Reader provides an alternative to the dominant narrative that positions Dominicans and Haitians as eternal adversaries and ignores cross-border and collaborative histories. This innovative anthology asks large-scale, universal questions regarding historical memory and revisionism that countries around the world grapple with today

Emergency medicine resident anesthesia training in a private vs. academic setting

pre-printAirway management is an essential part of any Emergency Medicine (EM) training program. Academic centers typically provide training to many learners at various training levels in a number of medical specialties during anesthesiology rotations. This potentially creates competition for intubation procedures that may negatively impact individual experiences. Objectives: We hypothesized that residents would report higher numbers of intubations and improved educational value in a private practice, rather than an academic, anesthesiology rotation. Methods: EM residents' anesthesiology training was evaluated pre and post a change in training setting from an academic institution to a private practice institution. Outcome measures included the number of self-reported intubations, resident ratings of the rotation, and the number of positive comments. Residents' evaluation was measured with: a 14-item evaluation; subjective comments, which two blinded reviewers rated as positive, negative, or neutral; and transcripts from structured interviews to identify themes related to training settings. Results: The number of intubations increased significantly in the private practice setting (4.6 intubations/day vs. 1.5 intubations/day, p < 0.001). Resident evaluations improved significantly with the private practice experience (mean scores of 3.83 vs. 2.23, p-values <0.05). Residents' impressions were also significantly higher for the private practice setting with respect to increased educational value, greater use of adjunct airway devices, and directed teaching. Conclusions: Number of intubations performed and residents' rating of the educational value were more favorable for a private practice anesthesiology rotation. Alternative settings may provide benefit for training in areas that have competition among trainees

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness

Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. The increasing range of parasite strains resistant to frontline therapeutics makes the identification of novel drug targets and the development of corresponding inhibitors vital. Post-translational modifications (PTMs) are important modulators of biology and inhibition of protein lipidation has emerged as a promising therapeutic strategy for treatment of parasitic diseases. In this review we summarize the latest insights into protein lipidation in protozoan parasites. We discuss how recent chemical proteomic approaches have delivered the first global overviews of protein lipidation in these organisms, contributing to our understanding of the role of this PTM in critical metabolic and cellular functions. Additionally, we highlight the development of new small molecule inhibitors to target parasite acyl transferases

Measuring 3D indoor air velocity via an inexpensive low-power ultrasonic anemometer

The ability to inexpensively monitor indoor air speed and direction on a continuous basis would transform the control of environmental quality and energy use in buildings. Air motion transports energy, ventilation air, and pollutants around building interiors and their occupants, and measured feedback about it could be used in numerous ways to improve building operation. However indoor air movement is rarely monitored because of the expense and fragility of sensors. This paper describes a unique anemometer developed by the authors, that measures 3-dimensional air velocity for indoor environmental applications, leveraging new microelectromechanical systems (MEMS) technology for ultrasonic range-finding. The anemometer uses a tetrahedral arrangement of four transceivers, the smallest number able to capture a 3-dimensional flow, that provides greater measurement redundancy than in existing anemometry. We describe the theory, hardware, and software of the anemometer, including algorithms that detect and eliminate shielding errors caused by the wakes from anemometer support struts. The anemometer has a resolution and starting threshold of 0.01 m/s, an absolute air speed error of 0.05 m/s at a given orientation with minimal filtering, 3.1° angle- and 0.11 m/s velocity errors over 360° azimuthal rotation, and 3.5° angle- and 0.07 m/s velocity errors over 135° vertical declination. It includes radio connection to internet and is able to operate standalone for multiple years on a standard battery. The anemometer also measures temperature and has a compass and tilt sensor so that flow direction is globally referenced regardless of anemometer orientation. The retail cost of parts is $100 USD, and all parts snap together for ease of assembly

Catatonia in Older Adult Individuals with Intellectual Disabilities

Catatonia has been described in children with intellectual disabilities (IDs). These are the first three published cases of catatonia in adults older than 50 years of age with IDs. They were followed using the KANNER scale and, in one case, creatinine phosphokinase (CPK) monitoring. Case 1 is a 67-year-old Caucasian who probably had been having intermittent episodes of undiagnosed catatonia withdrawal for many years. His episodes of agitation and withdrawal behavior responded to lorazepam up to 8 mg/day. Case 2 is a 63-year-old Caucasian male who had probably had undiagnosed catatonic episodes since age 25. An agitation episode that rated 88 on Part 2 of the KANNER scale ended within minutes after he received 1 mg of intramuscular lorazepam. He had no symptom relapses for 4 years after getting stable oral lorazepam doses (3-8.5 mg/day). Case 3 is a 55-year-old African-American male with severe ID and bradycardia (with a pacemaker). He had been institutionalized since age 22 and his undiagnosed catatonic episodes appeared to have been intermittently present for at least the last ten years. As he became tolerant and experienced symptom relapse, oral lorazepam was slowly increased (1.5-18 mg/day). Electroconvulsive therapy was ruled out due to his pacemaker

The nanoSIMS as a tool to study zonation around/in melt inclusions

Melt inclusions preserve geochemical records of magmatic processes and can provide windows into melt composition prior to near-surface fractionation processes such as degassing, crystal fractionation, and mixing that can influence the compositions of erupted magmas. The compositions of melt inclusions are usually measured near their centers using in-situ analytical techniques such as electron microprobe, ion probe, or LA-ICPMS. However, melt inclusions can experience post-entrapment modifications through crystallization or exchange with the host mineral or the outside melt via diffusion through the host mineral. For example, water loss (or gain) can occur by diffusion of H-bearing species through the host mineral toward (or from) the enclosing melt. Zonation in melt inclusions and their host minerals provide information on such post-entrapment modifications. We present a new approach to the study of such zonation using the nanoSIMS Cameca 50L high-resolution ion microprobe. Our data document mechanisms of chemical evolution of melt inclusion after entrapment and can constrain the nature and timescales of syn-eruptive processes

Unproceedings of the Fourth .Astronomy Conference (.Astronomy 4), Heidelberg, Germany, July 9-11 2012

The goal of the .Astronomy conference series is to bring together astronomers, educators, developers and others interested in using the Internet as a medium for astronomy. Attendance at the event is limited to approximately 50 participants, and days are split into mornings of scheduled talks, followed by 'unconference' afternoons, where sessions are defined by participants during the course of the event. Participants in unconference sessions are discouraged from formal presentations, with discussion, workshop-style formats or informal practical tutorials encouraged. The conference also designates one day as a 'hack day', in which attendees collaborate in groups on day-long projects for presentation the following morning. These hacks are often a way of concentrating effort, learning new skills, and exploring ideas in a practical fashion. The emphasis on informal, focused interaction makes recording proceedings more difficult than for a normal meeting. While the first .Astronomy conference is preserved formally in a book, more recent iterations are not documented. We therefore, in the spirit of .Astronomy, report 'unproceedings' from .Astronomy 4, which was held in Heidelberg in July 2012.Comment: 11 pages, 1 figure, .Astronomy 4, #dotastr