Centrifuge modeling of rocking-isolated inelastic RC bridge piers

Experimental proof is provided of an unconventional seismic design concept, which is based on deliberately underdesigning shallow foundations to promote intense rocking oscillations and thereby to dramatically improve the seismic resilience of structures. Termed rocking isolation, this new seismic design philosophy is investigated through a series of dynamic centrifuge experiments on properly scaled models of a modern reinforced concrete (RC) bridge pier. The experimental method reproduces the nonlinear and inelastic response of both the soil-footing interface and the structure. To this end, a novel scale model RC (1:50 scale) that simulates reasonably well the elastic response and the failure of prototype RC elements is utilized, along with realistic representation of the soil behavior in a geotechnical centrifuge. A variety of seismic ground motions are considered as excitations. They result in consistent demonstrably beneficial performance of the rocking-isolated pier in comparison with the one designed conventionally. Seismic demand is reduced in terms of both inertial load and deck drift. Furthermore, foundation uplifting has a self-centering potential, whereas soil yielding is shown to provide a particularly effective energy dissipation mechanism, exhibiting significant resistance to cumulative damage. Thanks to such mechanisms, the rocking pier survived, with no signs of structural distress, a deleterious sequence of seismic motions that caused collapse of the conventionally designed pier. © 2014 The Authors Earthquake Engineering & Structural Dynamics Published by John Wiley & Sons Ltd

Bulk Density of a Sandy Loam: Traffic, Tillage, and Irrigation-Method Effects

Modern crop production creates a cycle between soil compaction caused by traffic and alleviation of this condition by tillage or natural processes such as freezing and thawing. The objective of this study was to evaluate important management practices as they relate to changes in bulk density of a tilled sandy loam soil. Practices evaluated were irrigation method, time between tillage and traffic, tire pressure and wheel load of applied traffic, and controlled traffic. Relationships among bulk density, penetration resistance, and infiltration rate were determined. Experiments were conducted in the San Joaquin Valley of California, on a sandy loam soil (Entisol) with an organic-matter content of <1%. After tillage, settling and trafficking of a soil resulted in rapid changes in its bulk density until a new equilibrium was reached. Tire pressure of 408 kPa and wheel weight of 2724 kg applied at moisture contents near field capacity resulted in a bulk density of 1.92 Mg m-3 , compared with a value of 1.67 for no traffic. The time interval between tillage and traffic did not affect final bulk density. Drip irrigation, which did not saturate the soil, resulted in a bulk density of ≈0.1 Mg m-3 lower than flood irrigation, which saturated the soil surface. Wheel traffic in the furrow resulted in only small changes in the bulk density within the row. When tillage did not occur between cropping seasons, traffic caused high bulk densities in the furrow but only small changes in the row. An increase in bulk density from 1.7 to 1.89 Mg m-3 decreased the infiltration rate by four times and increased resistance to penetration at the end of the season by three times. Knowledge of how management practices affect bulk density can aid growers in reducing recompaction following tillage

Traveling wave deceleration of heavy polar molecules in low-field seeking states

We demonstrate the deceleration of heavy polar molecules in low-field seeking states by combining a cryogenic source and a travelling-wave Stark decelerator. The cryogenic source provides a high intensity beam with low speed and temperature, and the travelling-wave decelerator provides large deceleration forces and high phase-space acceptance. We prove these techniques using YbF molecules and find the experimental data to be in excellent agreement with numerical simulations. These methods extend the scope of Stark deceleration to a very wide range of molecules.Comment: 5 pages, 4 figure

Errors in Heat Flux Measurement by Flux Plates of Contrasting Design and Thermal Conductivity

The thermal conductivity (λ) of soils may vary by a factor of about 4 for a range of field soil water contents. Measurement of soil heat flux (G) using a heat flux plate with a fixed λ distorts heat flow through the plates and in the adjacent soil. The objectives of this research were to quantify heat flow distortion errors for soil heat flux plates of widely contrasting designs and to evaluate the accuracy of a previously reported correction. Six types of commercially available heat flux plates with varying thickness, face area, and thermal conductivity (λm) were evaluated. Steady-state laboratory experiments at flux densities from 20 to 175 W m−2 were completed in a large box filled with dry or saturated sand having λ of 0.36 and 2.25 W m−1K−1 A field experiment compared G measured with pairs of four plate types buried at 6 cm in a clay soil with G determined using the gradient technique. The flux plates underestimated G in the dry sand by 2.4 to 38.5% and by 13.1 to 73.2% in saturated sand while in moist clay plate performance ranged from a 6.2% overestimate to a 71.4% underestimate. Application of the correction generally improved agreement between plate estimates and independent Gmeasurements, especially when λ \u3e λm, although most plate estimates were still significantly lower than the actual G Limitations of the correction procedure indicate that renewed effort should be placed on innovative sensor designs that avoid or minimize heat flow distortion and/or provide direct, in situ calibration capability

A method for comparing the impact on carcinogenicity of tobacco products : a case study on heated tobacco versus cigarettes

This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose‐response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose‐response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10‐ to 25‐fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose‐response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures.Publisher PDFPeer reviewe

Evaluating Bioinformatic Pipeline Performance for Forensic Microbiome Analysis*,†,‡

Microbial communities have potential evidential utility for forensic applications. However, bioinformatic analysis of high‐throughput sequencing data varies widely among laboratories. These differences can potentially affect microbial community composition and downstream analyses. To illustrate the importance of standardizing methodology, we compared analyses of postmortem microbiome samples using several bioinformatic pipelines, varying minimum library size or minimum number of sequences per sample, and sample size. Using the same input sequence data, we found that three open‐source bioinformatic pipelines, MG‐RAST, mothur, and QIIME2, had significant differences in relative abundance, alpha‐diversity, and beta‐diversity, despite the same input data. Increasing minimum library size and sample size increased the number of low‐abundant and infrequent taxa detected. Our results show that bioinformatic pipeline and parameter choice affect results in important ways. Given the growing potential application of forensic microbiology to the criminal justice system, continued research on standardizing computational methodology will be important for downstream applications.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154468/1/jfo14213_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154468/2/jfo14213.pd

Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological evidence of joint damage. Mice heterozygous for PAR-2 gene disruption showed an intermediate phenotype. PAR-2 expression, normally limited to endothelial cells in small arterioles, was substantially upregulated 2 weeks after induction of inflammation, both in synovium and in other periarticular tissues. PAR-2 agonists showed potent proinflammatory effects as intra-articular injection of ASKH95, a novel synthetic PAR-2 agonist, induced prolonged joint swelling and synovial hyperemia. Given the absence of the chronic inflammatory response in the PAR-2-deficient mice, our findings demonstrate a key role for PAR-2 in mediating chronic inflammation, thereby identifying a novel and important therapeutic target for the management of chronic inflammatory diseases such as rheumatoid arthritis