Habilidades directivas y el desempeño docente en los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho 2016

Para las variables: V1 habilidades directivas, V2 desempeño docente, el estudio se abordó desde el enfoque cuantitativo ya que se centra en una investigación social. Según Hernández, Fernández y Batista (2010, p. 4) dijeron: “Enfoque cuantitativo usa la recolección de datos para probar hipótesis, con base en la medición numérica y el análisis estadístico, para establecer patrones de comportamiento y probar teorías”. Tal enfoque parte de un paradigma positivista cuyo objetivo es explicar y describir casualmente, así como generalizar, extrapolar, y universalizar, siendo el objeto de esa investigación hechos objetivos existentes sometidos a leyes y patrones generales. Se ha formulado la hipótesis general: Existe relación significativa entre las habilidades directivas y el desempeño docente en los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho. Metodológicamente se enmarcó en el tipo básico, nivel correlacional con un diseño no experimental transversal, el método es hipotético- deductivo, porque se observó el problema, se formuló hipótesis y se realizó la prueba oportuna. La población general fue 138 docentes de los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho, y se tomó una muestra de 107 docentes. En relación a la instrumentalización, se han formulado dos instrumentos de recolección de datos y ambos han pasado por los filtros correspondientes, cada uno de ellos con 20 ítems y con cinco alternativas de respuestas. Los resultados de la investigación se han realizado mediante el análisis descriptivo de las variables y el análisis inferencial para conocer el nivel de correlación mediante la prueba de Rho Spearman, contestando de esta manera al problema, verificando el cumplimiento de los objetivos y rechazando la hipótesis nula. Se llegó a la conclusión que existe una correlación significativa de 0,847** puntos entre las variables habilidades directivas y desempeño docente

Conferencia internacional. Desafíos de la Investigación e innovación en tiempos de Covid-19

En 2018, Treinta y nueve estudiantes femeninas del X ciclo del periodo 2018-1 de la escuela de Psicología de una universidad particular del cono norte de Lima, ellas han descrito el romance de su personas cercanas a ellas. Se analizaron los 266 casos de parejas de enamorados estaban el rango de 17 a 25 años. El instrumento que se usó fue una CUESTIONARIO CUPIDO que es una escala nominal de conductas donde las estudiantes de psicología clasificaban los comportamientos en categorías preestablecidas, claramente definidas y mutuamente excluyentes. La conclusión más importante del estudio observacional fue que las parejas analizadas en un 64.4 % la mujer ero atrajo al varón y después el varón emo conectó con la mujer. También han observado otro estilo de romance cuando el varón ero atrajo a la mujer por su cuerpo atracción y después la mujer fue la que emo conectó con el varón y observaron este hecho en un 35.6 % de los casos

Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children <18 years old, newly diagnosed with ALL and residents of GMC were included. Controls were patients without leukemia recruited from second-level public hospitals, frequency-matched by sex, age, and health institution with the cases. The residence address where the patients lived during the last year before diagnosis (cases) or the interview (controls) was used for geolocation. Kulldorff’s spatial scan statistic was used to detect spatial clusters (SCs). Relative risks (RR), associated p-value and number of cases included for each cluster were obtained.ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (p<0.0001) was observed for the main cluster. Similar results were noted for the remaining seven ones. Additionally, a proximity between SCs, electrical installations and petrochemical facilities was observed.ConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL

Habilidades directivas y el desempeño docente en los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho 2016

Para las variables: V1 habilidades directivas, V2 desempeño docente, el estudio se abordó desde el enfoque cuantitativo ya que se centra en una investigación social. Según Hernández, Fernández y Batista (2010, p. 4) dijeron: “Enfoque cuantitativo usa la recolección de datos para probar hipótesis, con base en la medición numérica y el análisis estadístico, para establecer patrones de comportamiento y probar teorías”. Tal enfoque parte de un paradigma positivista cuyo objetivo es explicar y describir casualmente, así como generalizar, extrapolar, y universalizar, siendo el objeto de esa investigación hechos objetivos existentes sometidos a leyes y patrones generales. Se ha formulado la hipótesis general: Existe relación significativa entre las habilidades directivas y el desempeño docente en los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho. Metodológicamente se enmarcó en el tipo básico, nivel correlacional con un diseño no experimental transversal, el método es hipotético- deductivo, porque se observó el problema, se formuló hipótesis y se realizó la prueba oportuna. La población general fue 138 docentes de los centros técnicos productivos de la UGEL Nº 05 San Juan de Lurigancho, y se tomó una muestra de 107 docentes. En relación a la instrumentalización, se han formulado dos instrumentos de recolección de datos y ambos han pasado por los filtros correspondientes, cada uno de ellos con 20 ítems y con cinco alternativas de respuestas. Los resultados de la investigación se han realizado mediante el análisis descriptivo de las variables y el análisis inferencial para conocer el nivel de correlación mediante la prueba de Rho Spearman, contestando de esta manera al problema, verificando el cumplimiento de los objetivos y rechazando la hipótesis nula. Se llegó a la conclusión que existe una correlación significativa de 0,847** puntos entre las variables habilidades directivas y desempeño docente

Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets

Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia

Evidence showing the role of long non-coding RNAs (lncRNAs) in leukemogenesis have emerged in the last decade. It has been proposed that these genes can be used as diagnosis and/or prognosis biomarkers in childhood acute lymphoblastic leukemia (ALL). To know if lncRNAs are associated with early relapse and early mortality, a microarray-based gene expression analysis in children with B-lineage ALL (B-ALL) was conducted. Cox regression analyses were performed. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated. LINC00152 and LINC01013 were among the most differentially expressed genes in patients with early relapse and early mortality. For LINC00152 high expression, the risks of relapse and death were HR: 4.16 (95% CI: 1.46–11.86) and HR: 1.99 (95% CI: 0.66–6.02), respectively; for LINC01013 low expression, the risks of relapse and death were HR: 3.03 (95% CI: 1.14–8.05) and HR: 6.87 (95% CI: 1.50–31.48), respectively. These results were adjusted by NCI risk criteria and chemotherapy regimen. The lncRNA–mRNA co-expression analysis showed that LINC00152 potentially regulates genes involved in cell substrate adhesion and peptidyl–tyrosine autophosphorylation biological processes. The results of the present study point out that LINC00152 could be a potential biomarker of relapse in children with B-ALL

DataSheet_2_NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia.docx

NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell function may result from an aberrant expression of such receptors, a condition often seen in patients with hematological cancers. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer worldwide and NK cells have emerged as crucial targets for developing immunotherapies. However, there are important gaps concerning the phenotype and behavior of NK cells during emergence of ALL. In this study we analyze the phenotype and function of NK cells from peripheral blood in pediatric patients with ALL at diagnosis. Our results showed that NK cells exhibited an altered phenotype highlighted by a significant reduction in the overall expression and percent representation of activating receptors compared to age-matched controls. No significant differences were found for the expression of inhibitory receptors. Moreover, NK cells with a concurrent reduced expression in various activating receptors, was the dominant phenotype among patients. An alteration in the relative frequencies of NK cells expressing NKG2A and CD57 within the mature NK cell pool was also observed. In addition, NK cells from patients displayed a significant reduction in the ability to sustain antibody-dependent cellular cytotoxicity (ADCC). Finally, an aberrant expression of activating receptors is associated with the phenomenon of leukemia during childhood.</p

DataSheet_1_NK cells with decreased expression of multiple activating receptors is a dominant phenotype in pediatric patients with acute lymphoblastic leukemia.pdf

NK cells have unique attributes to react towards cells undergoing malignant transformation or viral infection. This reactivity is regulated by activating or inhibitory germline encoded receptors. An impaired NK cell function may result from an aberrant expression of such receptors, a condition often seen in patients with hematological cancers. Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer worldwide and NK cells have emerged as crucial targets for developing immunotherapies. However, there are important gaps concerning the phenotype and behavior of NK cells during emergence of ALL. In this study we analyze the phenotype and function of NK cells from peripheral blood in pediatric patients with ALL at diagnosis. Our results showed that NK cells exhibited an altered phenotype highlighted by a significant reduction in the overall expression and percent representation of activating receptors compared to age-matched controls. No significant differences were found for the expression of inhibitory receptors. Moreover, NK cells with a concurrent reduced expression in various activating receptors, was the dominant phenotype among patients. An alteration in the relative frequencies of NK cells expressing NKG2A and CD57 within the mature NK cell pool was also observed. In addition, NK cells from patients displayed a significant reduction in the ability to sustain antibody-dependent cellular cytotoxicity (ADCC). Finally, an aberrant expression of activating receptors is associated with the phenomenon of leukemia during childhood.</p

Table_1_Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.xlsx

BackgroundA heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).MethodsA population-based case-control study was conducted. Children ResultsA total of 1054 cases with ALL were analyzed. Of these, 408 (38.7%) were distributed across eight SCs detected. A relative risk of 1.61 (pConclusionsThe identification of SCs in certain regions of GMC suggest the possible role of environmental factors in the etiology of childhood ALL.</p