Indoor Positioning by LED Visible Light Communication and Image Sensors

High power white LEDs are expected to replace the existing lighting technologies in near future which are also suggested for visible light communication (VLC). We proposed an algorithm for high precision indoor positioning using lighting LEDs, VLC and image sensors. In the proposed algorithm, four LEDs transmitted their three-dimensional coordinate information which were received and demodulated by two image sensors near the unknown position. The unknown position was then calculated from the geometrical relations of the LED images created on the image sensors. We described the algorithm in details. Simulation of the proposed algorithm was done and presented in this paper. This technique did not require any angular measurement which was needed in contemporary positioning algorithms using LED and image sensor. Simulation results showed that the proposed system could estimate the unknown position within the accuracy of few centimeters. Positioning accuracy could be increased by using high resolution image sensors or by increasing the separation between the image sensors.DOI:http://dx.doi.org/10.11591/ijece.v1i2.16

Activation of the Renin–Angiotensin System Disrupts the Cytoskeletal Architecture of Human Urine-Derived Podocytes

High blood pressure is one of the major public health problems that causes severe disorders in several tissues including the human kidney. One of the most important signaling pathways associated with the regulation of blood pressure is the renin–angiotensin system (RAS), with its main mediator angiotensin II (ANGII). Elevated levels of circulating and intracellular ANGII and aldosterone lead to pro-fibrotic, -inflammatory, and -hypertrophic milieu that causes remodeling and dysfunction in cardiovascular and renal tissues. Furthermore, ANGII has been recognized as a major risk factor for the induction of apoptosis in podocytes, ultimately leading to chronic kidney disease (CKD). In the past, disease modeling of kidney-associated diseases was extremely difficult, as the derivation of kidney originated cells is very challenging. Here we describe a differentiation protocol for reproducible differentiation of sine oculis homeobox homolog 2 (SIX2)-positive urine-derived renal progenitor cells (UdRPCs) into podocytes bearing typical cellular processes. The UdRPCs-derived podocytes show the activation of the renin–angiotensin system by being responsive to ANGII stimulation. Our data reveal the ANGII-dependent downregulation of nephrin (NPHS1) and synaptopodin (SYNPO), resulting in the disruption of the podocyte cytoskeletal architecture, as shown by immunofluorescence-based detection of α-Actinin. Furthermore, we show that the cytoskeletal disruption is mainly mediated through angiotensin II receptor type 1 (AGTR1) signaling and can be rescued by AGTR1 inhibition with the selective, competitive angiotensin II receptor type 1 antagonist, losartan. In the present manuscript we confirm and propose UdRPCs differentiated to podocytes as a unique cell type useful for studying nephrogenesis and associated diseases. Furthermore, the responsiveness of UdRPCs-derived podocytes to ANGII implies potential applications in nephrotoxicity studies and drug screening

The illusion of creation of the text

Is it really possible to create a (literary) text? It is actually impossible as to create an authentic text we need an authentic context which is impossible to create. So all the literary txets we have are not authentic and are not created authentically

The illusion of creation of the text

Is it really possible to create a (literary) text? It is actually impossible as to create an authentic text we need an authentic context which is impossible to create. So all the literary txets we have are not authentic and are not created authentically

Balancing Ethics and Profitability : Strategies for Nestle to Overcome Ethical Scandals and Enhance Reputation

The thesis "Balancing Ethics and Profitability: Strategies for Nestle to Overcome Ethical Scandals and Enhance Reputation" explores the importance of ethical practices in business, with a focus on Nestle's sustainability efforts and ethical conduct. It analyzes the impact of ethical scandals on Nestle's reputation and consumer trust, providing strategic solutions for enhancing corporate ethics. The thesis aims to guide Nestle in balancing profitability with ethical considerations to overcome ethical dilemmas and improve its overall reputation

Molecular biology and riddle of cancer: the ‘Tom & Jerry’ show

From the conventional Bird’s eye, cancer initiation and metastasis are generally intended to be understood beneath the light of classical clonal genetic, epigenetic and cancer stem cell model. But inspite decades of investigation, molecular biology has shown hard success to give Eagle’s eye in unraveling the riddle of cancer. And it seems, tiring Tom runs in vague behind naughty Jerry