McNair Andrew - Callison College One Pager

https://scholarlycommons.pacific.edu/callison-college-sis/1022/thumbnail.jp

Visualizing Software Architecture Evolution Using Change-Sets

When trying to understand the evolution of a software system it can be useful to visualize the evolution of the sys-tem’s architecture. Existing tools for viewing architectural evolution assume that what a user is interested in can be described in an unbroken sequence of time, for example the changes over the last six months. We present an alternative approach that provides a lightweight method for examining the net effect of any set of changes on a system’s architec-ture. We also present Motive, a prototype tool that imple-ments this approach, and demonstrate how it can be used to answer questions about software evolution by describing case studies we conducted on two Java systems.

The Similkameen Batholith of North-Central Washington and South-Central British Columbia: The Petrotectonic Significance of an Alkaline/Calc-Alkaline Magmatic Complex

The Similkameen batholith is a 170 Ma plutonic complex that contains coeval mafic alkaline and granitic calc-alkaline assemblages. The marginal mafic alkaline suite is silica-undersaturated, characteristically potassic in composition and comprised of malignite, shonkinite, and mafic syenites (+/- nepheline) with biotite and amphibole-bearing pyroxenite cumulates. The granitic plutons of the core are calc-alkaline, I-type, ranging from monzonite to granodiorite to granite in composition. Structural and petrofabric studies indicate that the mafic alkaline suite was intuded and deformed by the calc-alkaline granitoids. Magmatic fabrics within the mafic rocks are concentric to the lithologic zonations and have been overprinted by sub-magmatic flow deformation induced by diapiric emplacement of the core. There is no evidence within the batholith for regional deformation associated with the collision of Quesnellia and North America. Major and trace element variations as well as Sr-isotopic data indicate that the alkaline and calc-alkaline suites are not related by crystal fractionation. However, crystal fractionation appears to have been the dominant process responsible for major element variations within the mafic alkaline suite. Fractionation of the hydrous assemblage clinopyroxene +/- biotite +/- amphibole + apatite + magnetite accounts for compositional variations within the alkaline suite. Calculated modal abundances of the fractionated mineral phases closely approximates observed modal abundances within the pyroxenites, which supports a crystal accumulation origin for the ultramafic rocks. The alkaline and calc-alkaline suites exhibit a geochemical signature characteristic of subduction-related magmatism. Both suites are enriched in alkali and alkaline earth elements and depleted in high field strength elements. Major and trace element compositions of the mafic alkaline suite are consistent with partial melting of a garnet and phlogopite-bearing peridotite source. However, trace element variations within the alkaline suite demonstrate derivation from a chemically heterogeneous mantle-source. The malignite series contains incompatible element ratios consistent with a depleted MORB-type source, whereas the shonkinite series appears to be enriched, indicative of an OIB-type source. The Ba-enrichments of the malignites relative to the shonkinites probably reflect variations in source mineralogy, i.e., greater amounts of phlogopite in the source, not contamination by pelagic sediments. Furthermore, the low variability of initial-Sr ratios (0.7037-0.7042) indicates contamination of the Similkameen magmas by continental crust was relatively minor. Variable degree partial melting of a lower crustal mafic granulite source could produce the incompatible element, REE, and isotopic abundances observed within the calc-alkaline granitoids. Subduction and plate tectonic processes prior to 170 Ma variably enriched (metasomatized) portions of the lithospheric mantle wedge below the western edge of the North American craton. Derivation from this heterogeneous, metasomatized mantle- source resulted in the variably enriched nature of the mafic rocks. The granitoid magmas were the probable result of partial melting related to ponding of hot, hydrous mafic magmas of the alkaline suite at the lower crust-mantle boundary

The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration

Mitral valve prolapse (MVP) due to myxomatous degeneration is one of the most important chronic degenerative cardiovascular diseases in people and dogs. It is a common cause of heart failure leading to significant morbidity and mortality in both species. Human MVP is usually classified into primary or non-syndromic, including Barlow’s Disease (BD), fibro-elastic deficiency (FED) and Filamin-A mutation, and secondary or syndromic forms (typically familial), such as Marfan syndrome (MFS), Ehlers-Danlos syndrome, and Loeys–Dietz syndrome. Despite different etiologies the diseased valves share pathological features consistent with myxomatous degeneration. To reflect this common pathology the condition is often called myxomatous mitral valve degeneration (disease) (MMVD) and this term is universally used to describe the analogous condition in the dog. MMVD in both species is characterized by leaflet thickening and deformity, disorganized extracellular matrix, increased transformation of the quiescent valve interstitial cell (qVICs) to an activated state (aVICs), also known as activated myofibroblasts. Significant alterations in these cellular activities contribute to the initiation and progression of MMVD due to the increased expression of transforming growth factor-β (TGF-β) superfamily cytokines and the dysregulation of the TGF-β signaling pathways. Further understanding the molecular mechanisms of MMVD is needed to identify pharmacological manipulation strategies of the signaling pathway that might regulate VIC differentiation and so control the disease onset and development. This review briefly summarizes current understanding of the histopathology, cellular activities, molecular mechanisms and pathogenesis of MMVD in dogs and humans, and in more detail reviews the evidence for the role of TGF-β

The effects of experimental knee pain on lower limb corticospinal and motor cortex excitability

Notable weakness of the quadriceps muscles is typically observed as a consequence of knee joint arthritis, knee surgery and knee injury. This is partly due to ongoing neural inhibition that prevents the central nervous system from fully activating the quadriceps, a process known as arthrogenic muscle inhibition (AMI). To investigate the mechanisms underlying AMI, this study explored the effects of experimental knee pain on lower limb corticospinal and motor cortex excitability

Making the News: Digital Creativity Support for Journalists

This paper reports the design and first evaluations of new digital support for journalists to discover and examine creative angles on news stories under development. The support integrated creative news search algorithms, interactive creative sparks and reusable concept cards into one daily work tool of journalists. The first evaluations of INJECT by journalists in their places of work to write published news stories revealed that the journalists generated new angles on existing stories rather than new stories, changed their writing behaviour, and reported evidence that INJECT use had the potential to increase the objectivity and the boldness of journalism methods used