Models for the Effects of G-seat Cuing on Roll-axis Tracking Performance

Including whole-body motion in a flight simulator improves performance for a variety of tasks requiring a pilot to compensate for the effects of unexpected disturbances. A possible mechanism for this improvement is that whole-body motion provides high derivative vehicle state information whic allows the pilot to generate more lead in responding to the external disturbances. During development of motion simulating algorithms for an advanced g-cuing system it was discovered that an algorithm based on aircraft roll acceleration producted little or no performance improvement. On the other hand, algorithms based on roll position or roll velocity produced performance equivalent to whole-body motion. The analysis and modeling conducted at both the sensory system and manual control performance levels to explain the above results are described

Impracticable, inhospitable, and dismal country : An examination of the environmental impact on Civil War military operations in West Virginia

“Impracticable, Inhospitable, and Dismal Country” examines the role of the natural environment in the campaign fought along Tygart’s Valley River in West Virginia during the summer and early fall of 1861. In the weeks following the capitulation of Fort Sumter, it became clear that hostilities would break out in present-day West Virginia. Divided political sentiments between secessionists and Unionists, combined with vital transportation avenues including turnpikes, the Ohio River, and the critical Baltimore and Ohio Railroad, forced the region into the crosshairs of regular military operations. As soldiers from both Union and Confederate armies mobilized in West Virginia, they soon began to understand the natural environment would play a critical role in determining the fight there. More than an arena of combat, the natural environment was a third participant in the fight for the Mountain State. This thesis contributes to the subfield of environmental Civil War studies by analyzing the intersection of environment and war in a unique theater of the Civil War. As the role of the natural environment on military operations in West Virginia has not received thorough scholarly attention, this thesis also helps to push forward the historiography of the Civil War in Appalachia. Topography, weather, and disease were all environmental factors that affected command decisions and impacted the common soldier experience. Both sides could alter the landscape into a natural ally, but the Federals were more proficient in adapting to and overcoming the natural environment. Union victories enabled the unimpeded progress of the Reorganized Government of Virginia and the eventual formation of the state of West Virginia

An integrated approach to the interpretation of Single Amino Acid Polymorphisms within the framework of CATH and Gene3D

Background: The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stability. In order better to understand the mechanisms behind known mutant phenotypes, and predict the effects of novel variations, biologists need tools to gauge the impacts of DNA mutations in terms of their structural manifestation. Although many mutations occur within domains whose structure has been solved, many more occur within genes whose protein products have not been structurally characterized.Results: Here we present 3DSim (3D Structural Implication of Mutations), a database and web application facilitating the localization and visualization of single amino acid polymorphisms (SAAPs) mapped to protein structures even where the structure of the protein of interest is unknown. The server displays information on 6514 point mutations, 4865 of them known to be associated with disease. These polymorphisms are drawn from SAAPdb, which aggregates data from various sources including dbSNP and several pathogenic mutation databases. While the SAAPdb interface displays mutations on known structures, 3DSim projects mutations onto known sequence domains in Gene3D. This resource contains sequences annotated with domains predicted to belong to structural families in the CATH database. Mappings between domain sequences in Gene3D and known structures in CATH are obtained using a MUSCLE alignment. 1210 three-dimensional structures corresponding to CATH structural domains are currently included in 3DSim; these domains are distributed across 396 CATH superfamilies, and provide a comprehensive overview of the distribution of mutations in structural space.Conclusion: The server is publicly available at http://3DSim.bioinfo.cnio.es/. In addition, the database containing the mapping between SAAPdb, Gene3D and CATH is available on request and most of the functionality is available through programmatic web service access

How men and women learn about sex: multi-generational perspectives on insufficient preparedness and prevailing gender norms in Scotland

Attitudes towards sexual health and relationships are learned from a young age, and there is an ongoing need for innovative and comprehensive approaches to sex education that keep pace with rapidly changing contexts of people’s lives. We used thematic analysis of data from two qualitative studies in Scotland to explore learning contexts from a multi-generational perspective, as well as the influence of different socio-cultural factors on provision, access to and experience of sex education. The importance, but inadequacy, of school as a source of learning, was a persistent theme over time. Participants’ strategies to address perceived gaps in knowledge included experience, conversations, vicarious and online learning. Gender and age differences emerged, with younger participants more likely to go online for information, and prevailing gender norms shaping attitudes and behaviours across both study groups. Participants who identified as gay, lesbian or bisexual described feeling particularly unprepared for sex and relationships due to the narrow, heteronormative content received. Although schools continue to be a common source of information, it appears that they fail to equip young people for their post-school sexual life-course. We recommend the mandatory provision of comprehensive, positive, inclusive and skills-based learning to improve people’s chances of forming and building healthy, positive relationships across the lifespan

Structural studies and polymorphism in amorphous solids and liquids at high pressure

When amorphous materials are compressed their structures are expected to change in response to densification. In some cases, the changes in amorphous structure can be discontinuous and they can even have the character of first-order phase transitions. This is a phenomenon referred to as polyamorphism. Most evidence for polyamorphic transitions between low and high density liquids or analogous transformations between amorphous forms of the same substance to date has been indirect and based on the changes in thermodynamic and other structure-related properties with pressure. Recent studies using advanced X-ray and neutron scattering methods combined with molecular dynamics simulations are now revealing the details of structural changes in polyamorphic systems as a function of pressure. Various "two state'' or "two species'' models are used to understand the anomalous densification behaviour of liquids with melting curve maxima or regions of negative melting slope. Thermodynamic analysis of the two state model leads to the possibility of low- to high-density liquid transitions caused by differences in bulk thermodynamic properties between different amorphous forms and on the degree of cooperativity between low- and high-density structural configurations. The potential occurrence of first-order transitions between supercooled liquids is identified as a critical-like phenomenon. In this tutorial review we discuss the background to polyamorphism, incorporating the experimental observations, simulation studies and the two-state models. We also describe work carried on several systems that are considered to be polyamorphic

Structural transformations and disordering in zirconolite (CaZrTi2O7) at high pressure

There is interest in identifying novel materials for use in radioactive waste applications and studying their behavior under high pressure conditions. The mineral zirconolite (CaZrTi2O7) exists naturally in trace amounts in diamond-bearing deep-seated metamorphic/igneous environments, and it is also identified as a potential ceramic phase for radionuclide sequestration. However, it has been shown to undergo radiation-induced metamictization resulting in amorphous forms. In this study we probed the high pressure structural properties of this pyrochlore-like structure to study its phase transformations and possible amorphization behavior. Combined synchrotron X-ray diffraction and Raman spectroscopy studies reveal a series of high pressure phase transformations. Starting from the ambient pressure monoclinic structure, an intermediate phase with P21/m symmetry is produced above 15.6 GPa via a first order transformation resulting in a wide coexistence range. Upon compression to above 56 GPa a disordered metastable phase III with a cotunnite-related structure appears that is recoverable to ambient conditions. We examine the similarity between the zirconolite behavior and the structural evolution of analogous pyrochlore systems under pressure.<br/

Phase diagram of silicon from atomistic simulations

In this letter we present a calculation of the temperature-pressure phase diagram of Si in a range of pressures covering from -5 to 20 GPa and temperatures up to the melting point. The phase boundaries and triple points between the diamond, liquid, $\beta$-Sn and ${Si}_{34}$ clathrate phases are reported. We have employed efficient simulation techniques to calculate free energies and to numerically integrate the Clausius-Clapeyron equation, combined with a tight binding model capable of an accuracy comparable to that of first-principles methods. The resulting phase diagram agrees well with the available experimental data.Comment: 5 pages, 1 figure, accepted in PR

Two-photon interference between disparate sources for quantum networking

Quantum networks involve entanglement sharing between multiple users. Ideally, any two users would be able to connect regardless of the type of photon source they employ, provided they fulfill the requirements for two-photon interference. From a theoretical perspective, photons coming from different origins can interfere with a perfect visibility, provided they are made indistinguishable in all degrees of freedom. Previous experimental demonstrations of such a scenario have been limited to photon wavelengths below 900 nm, unsuitable for long distance communication, and suffered from low interference visibility. We report two-photon interference using two disparate heralded single photon sources, which involve different nonlinear effects, operating in the telecom wavelength range. The measured visibility of the two-photon interference is 80+/-4%, which paves the way to hybrid universal quantum networks

Offshore wind turbine sub-assembly failure rates through time

O&M costs can make up to 30% of the lifetime CoE of an offshore wind farm [1]. As a means of reducing this cost operators and O&M providers need a greater understanding of what is driving that O&M cost. Failure rates of wind turbines and their components are a key driver of O&M costs. Past papers have modelled O&M costs assuming a fixed average failure rate for wind turbine subsystems [2]. This work aims to determine if it is accurate to assume a fixed failure rate or if a failure rate distribution through time can be provided to allow for more accurate O&M cost modelling and in turn CoE modelling. This paper shows the results of an analysis of offshore wind turbine annual failure rates over an 8 year period. The analysis is based on around 350 modern multi MW offshore turbines located in 5-10 offshore wind farms throughout Europe. The literature review for this paper indicated that a constant average failure rate should only be used if the shape parameter of the failure distribution is around 1. However results from the failure rate analysis in this paper have shown that in many cases a constant failure rate is not correct for O&M Modelling

Goodness-of-fit and generalized estimating equation methods for ordinal responses based on the stereotype model

Background: Data with ordinal categories occur in many diverse areas, but methodologies for modeling ordinal data lag severely behind equivalent methodologies for continuous data. There are advantages to using a model specifically developed for ordinal data, such as making fewer assumptions and having greater power for inference. Methods: The ordered stereotype model (OSM) is an ordinal regression model that is more flexible than the popular proportional odds ordinal model. The primary benefit of the OSM is that it uses numeric encoding of the ordinal response categories without assuming the categories are equally-spaced. Results: This article summarizes two recent advances in the OSM: (1) three novel tests to assess goodness-of-fit; (2) a new Generalized Estimating Equations approach to estimate the model for longitudinal studies. These methods use the new spacing of the ordinal categories indicated by the estimated score parameters of the OSM. Conclusions: The recent advances presented can be applied to several fields. We illustrate their use with the well-known arthritis clinical trial dataset. These advances fill a gap in methodologies available for ordinal responses and may be useful for practitioners in many applied fieldsThis research has been supported by Marsden grant E2987-3648 administrated by the Royal Society of New Zealand, by grant 2017 SGR 622 (GRBIO) administrated by the Departament d’Economia i Coneixement de la Generalitat de Catalunya (Spain) and by the Ministerio de Ciencia e Innovación (Spain) [PID2019-104830RB-I00/ DOI (AEI): 10.13039/501100011033].Peer ReviewedPostprint (published version