2,229 research outputs found
Planet Four: Terrains - Discovery of Araneiforms Outside of the South Polar Layered Deposits
We present the results of a systematic mapping of seasonally sculpted
terrains on the South Polar region of Mars with the Planet Four: Terrains (P4T)
online citizen science project. P4T enlists members of the general public to
visually identify features in the publicly released Mars Reconnaissance Orbiter
CTX images. In particular, P4T volunteers are asked to identify: 1) araneiforms
(including features with a central pit and radiating channels known as
'spiders'); 2) erosional depressions, troughs, mesas, ridges, and
quasi-circular pits characteristic of the South Polar Residual Cap (SPRC) which
we collectively refer to as 'Swiss cheese terrain', and 3) craters. In this
work we present the distributions of our high confidence classic spider
araneiforms and Swiss cheese terrain identifications. We find no locations
within our high confidence spider sample that also have confident Swiss cheese
terrain identifications. Previously spiders were reported as being confined to
the South Polar Layered Deposits (SPLD). Our work has provided the first
identification of spiders at locations outside of the SPLD, confirmed with high
resolution HiRISE imaging. We find araneiforms on the Amazonian and Hesperian
polar units and the Early Noachian highland units, with 75% of the identified
araneiform locations in our high confidence sample residing on the SPLD. With
our current coverage, we cannot confirm whether these are the only geologic
units conducive to araneiform formation on the Martian South Polar region. Our
results are consistent with the current CO2 jet formation scenario with the
process exploiting weaknesses in the surface below the seasonal CO2 ice sheet
to carve araneiform channels into the regolith over many seasons. These new
regions serve as additional probes of the conditions required for channel
creation in the CO2 jet process. (Abridged)Comment: accepted to Icarus - Supplemental data files are available at
https://www.zooniverse.org/projects/mschwamb/planet-four-terrains/about/results
- Icarus print version available at
http://www.sciencedirect.com/science/article/pii/S001910351730055
Recommended from our members
VeSPA: The SuperWASP Variable Star Photometry Archive
SuperWASP Variable Stars is a Zooniverse citizen science project in which the public label photometric light curve plots showing potential variations in stellar brightness. The volunteers label each plot as one of several types of variable star, or as âunknownâ or âjunkâ. Their labels are combined to produce an aggregated classification. We are publishing the first data release from the project via an interactive website called VeSPA. The results can be searched, filtered, and exported in CSV format. Raw FITS data is available to download
Recommended from our members
A SuperWASP Light Curve Displaying a Single Long-duration Transit: A Jupiter Size Exoplanet in a Very Distant Orbit?
We present the SuperWASP light curve of a 10th magnitude A7V star containing a single, well-defined U-shaped transit-like event lasting around 11âdays with a depth of 1.1%. The star is otherwise non-variable throughout the 8 yr duration of the observations. If the event is modeled as an exoplanet transit, it is compatible with a 1.8âRJ exoplanet in a âŒ205âau orbit with a period of âŒ2200âyr
Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension
Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic reticulum (ER) stress have been implicated in hypertension. However, relationships between these processes are unclear. We hypothesized that Nox isoforms localize in a subcellular compartment-specific manner, contributing to oxidative and ER stress, which influence the oxidative proteome and vascular function in hypertension. Nox compartmentalization (cell fractionation), O2â (lucigenin), H2O2 (amplex red), reversible protein oxidation (sulfenylation), irreversible protein oxidation (protein tyrosine phosphatase, peroxiredoxin oxidation), and ER stress (PERK [protein kinase RNA-like endoplasmic reticulum kinase], IRE1α [inositol-requiring enzyme 1], and phosphorylation/oxidation) were studied in spontaneously hypertensive rat (SHR) vascular smooth muscle cells (VSMCs). VSMC proliferation was measured by fluorescence-activated cell sorting, and vascular reactivity assessed in stroke-prone SHR arteries by myography. Noxs were downregulated by short interfering RNA and pharmacologically. In SHR, Noxs were localized in specific subcellular regions: Nox1 in plasma membrane and Nox4 in ER. In SHR, oxidative stress was associated with increased protein sulfenylation and hyperoxidation of protein tyrosine phosphatases and peroxiredoxins. Inhibition of Nox1 (NoxA1ds), Nox1/4 (GKT137831), and ER stress (4-phenylbutyric acid/tauroursodeoxycholic acid) normalized SHR vascular reactive oxygen species generation. GKT137831 reduced IRE1α sulfenylation and XBP1 (X-box binding protein 1) splicing in SHR. Increased VSMC proliferation in SHR was normalized by GKT137831, 4-phenylbutyric acid, and STF083010 (IRE1âXBP1 disruptor). Hypercontractility in the stroke-prone SHR was attenuated by 4-phenylbutyric acid. We demonstrate that protein hyperoxidation in hypertension is associated with oxidative and ER stress through upregulation of plasmalemmal-Nox1 and ER-Nox4. The IRE1âXBP1 pathway of the ER stress response is regulated by Nox4/reactive oxygen species and plays a role in the hyperproliferative VSMC phenotype in SHR. Our study highlights the importance of Nox subcellular compartmentalization and interplay between cytoplasmic reactive oxygen species and ER stress response, which contribute to the VSMC oxidative proteome and vascular dysfunction in hypertensio
Planet Four: Probing springtime winds on Mars by mapping the southern polar CO2 jet deposits
The springtime sublimation process of Marsâ southern seasonal polar CO2 ice cap features dark fan-shaped de- posits appearing on the top of the thawing ice sheet. The fan material likely originates from the surface below the ice sheet, brought up via CO2 jets breaking through the seasonal ice cap. Once the dust and dirt is released into the atmosphere, the material may be blown by the surface winds into the dark streaks visible from orbit. The location, size and direction of these fans record a number of parameters important to quantifying seasonal winds and sublimation activity, the most important agent of geological change extant on Mars. We present results of a systematic mapping of these south polar seasonal fans with the Planet Four online citizen science project. Planet Four enlists the general public to map the shapes, directions, and sizes of the seasonal fans visible in orbital images. Over 80,000 volunteers have contributed to the Planet Four project, reviewing 221 images, from Mars Reconnaissance Orbiterâs HiRISE (High Resolution Imaging Science Experiment) camera, taken in southern spring during Mars Years 29 and 30. We provide an overview of Planet Four and detail the processes of combining multiple volunteer assessments together to generate a high delity catalog of ⌠400000 south polar seasonal fans. We present the results from analyzing the wind directions at several locations monitored by HiRISE over two Mars years, providing new insights into polar surface winds
Formation of a copper(II)-tyrosyl complex at the active site of lytic polysaccharide monooxygenases following oxidation by H2O2
Hydrogen peroxide is a cosubstrate for the oxidative cleavage of saccharidic substrates by copper-containing lytic polysaccharide monooxygenases (LPMOs). The rate of reaction of LPMOs with hydrogen peroxide is high, but it is accompanied by rapid inactivation of the enzymes, presumably through protein oxidation. Herein, we use UVâ vis, CD, XAS, EPR, VT/VH-MCD, and resonance Raman spectroscopies, augmented with mass spectrometry and DFT calculations, to show that the product of reaction of an AA9 LPMO with H2O2 at higher pHs is a singlet Cu(II)âtyrosyl radical species, which is inactive for the oxidation of saccharidic substrates. The Cu(II)âtyrosyl radical center entails the formation of signiïŹcant Cu(II)â(âOTyr) overlap, which in turn requires that the plane of the d(x2ây2) SOMO of the Cu(II) is orientated toward the tyrosyl radical. We propose from the Marcus cross-relation that the active site tyrosine is part of a âhole-hoppingâ charge-transfer mechanism formed of a pathway of conserved tyrosine and tryptophan residues, which can protect the protein active site from inactivation during uncoupled turnover
Recommended from our members
Disaster, Infrastructure and Participatory Knowledge:The Planetary Response Network
There are many challenges involved in online participatory humanitarian response. We evaluate the Planetary Response Network (PRN), a collaboration between researchers, humanitarian organizations, and the online citizen science platform Zooniverse. The PRN uses satellite and aerial image analysis to provide stakeholders with high-level situational awareness during and after humanitarian crises. During past deployments, thousands of online volunteers have compared pre- and post-event satellite images to identify damage to infrastructure and buildings, access blockages, and signs of people in distress. In addition to collectively producing aggregated âheat mapsâ of features that are shared with responders and decision makers, individual volunteers may also flag novel features directly using integrated community discussion software. The online infrastructure facilitates worldwide participation even for geographically focused disasters; this widespread public participation means that high-value information can be delivered rapidly and uniformly even for large-scale crises. We discuss lessons learned from deployments, place the PRNâs distributed online approach in the context of more localized efforts, and identify future needs for the PRN and similar online crisis-mapping projects. The successes of the PRN demonstrate that effective online crisis mapping is possible on a generalized citizen science platform such as the Zooniverse
- âŠ