McMannis Family History

This is the story of the McMannis Family with its history and stories written by Jeremy McManni

The McMannis Family Fan Chart

The McMannis Family Fan Chart showing 7 generations By: J. McMannis 2016 This Family Fan Chart was created as a graduate project detailing the 7 generations of my family I can locate. https://familysearch.org

The McMannis Family Pedigree Chart

The Family Pedigree of the McMannis Family By: J. McMannis This Family Pedigree was started as a class requirement to trace your family\u27s history back through time. https://familysearch.org

2: Donor-Recipient Host-Versus-Graft Human Leukocyte Antigen Mismatches and Outcome of Cord Blood Transplants

Digitalitzat per Artypla

Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans

Background: Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of–function genetic abnormalities. We report the first in-human systemic gene therapy clinical trial of tumor suppressor gene TUSC2. Methods: Patients with recurrent and/or metastatic lung cancer previously treated with platinum-based chemotherapy were treated with escalating doses of intravenous N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP):cholesterol nanoparticles encapsulating a TUSC2 expression plasmid (DOTAP:chol-TUSC2) every 3 weeks. Results: Thirty-one patients were treated at 6 dose levels (range 0.01 to 0.09 milligrams per kilogram). The MTD was determined to be 0.06 mg/kg. Five patients achieved stable disease (2.6–10.8 months, including 2 minor responses). One patient had a metabolic response on positron emission tomography (PET) imaging. RT-PCR analysis detected TUSC2 plasmid expression in 7 of 8 post-treatment tumor specimens but not in pretreatment specimens and peripheral blood lymphocyte controls. Proximity ligation assay, performed on paired biopsies from 3 patients, demonstrated low background TUSC2 protein staining in pretreatment tissues compared with intense (10–25 fold increase) TUSC2 protein staining in posttreatment tissues. RT-PCR gene expression profiling analysis of apoptotic pathway genes in two patients with high posttreatmen

Fruit-feeding in European cold season noctuid moths increases fecundity, but not longevity

Feeding on rotting fruits, rather than nectar, is linked to high adult life-expectancy in certain butterflies, notably tropical Nymphalidae. We experimentally tested whether cold-season central European noctuid moths may also derive longevity and fecundity benefits from feeding on fruits. Many cold-season noctuid moths avidly feed on such resources. We expected fitness benefits to be especially pronounced in moths which overwinter as adults, in relation to their unusually long and thus nutrient-demanding imaginal life (6–9 months). Field-caught female individuals representing four genera (Allophyes Tams, 1942; Agrochola Hübner, 1821; Conistra Hübner, 1821; Eupsilia Hübner, 1821) were offered sucrose solution, sucrose solution enriched with vitamins, or moisturized banana slices plus sucrose solution, respectively, under greenhouse conditions. These moths represented two life-cycle types (autumn species vs. adult hibernators). Life span differed between moth genera, but we did not observe any enhancement of life span through fruit-feeding. Rather, in some cases moths kept with access to banana slices experienced a minor reduction in life span, compared to moths fed sucrose solution only. We observed no benefits in terms of enhanced fecundity through fruit-feeding in autumn species. Among adult hibernators, in contrast, potential fecundity increased by over 50% in banana-fed females, when observed over their full lifetime. Yet, if kept in the lab only after completing their hibernation in the wild, fitness benefits no longer accrued to moths from supplementing their diet with fruits. We conclude that noctuids that hibernate as adults are indeed income breeders which potentially increase their fecundity by feeding on fruits