Children\u27s Folklore

A collection of original essays by scholars from a variety of fields—including American studies, folklore, anthropology, psychology, sociology, and education—Children\u27s Folklore: A Source Book moves beyond traditional social-science views of child development. It reveals the complexity and artistry of interactions among children, challenging stereotypes of simple childhood innocence and conventional explanations of development that privilege sober and sensible adult outcomes. Instead, the play and lore of children is shown to be often disruptive, wayward, and irrational. The contributors variably con-sider and demonstrate contextual and textual ways of studying the folklore of children. Avoiding a narrow definition of the subject, they examine a variety of resources and approaches for studying, researching, and teaching it. These range from surveys of the history and literature of children\u27s folklore to methods of field research, studies of genres of lore, and attempts to capture children\u27s play and games.https://digitalcommons.usu.edu/usupress_pubs/1059/thumbnail.jp

Teriparatide and Pelvic Fracture Healing: A Phase 2 Randomized Controlled Trial

Purpose: To determine if teriparatide (20 ug/day; TPTD) results in improved radiologic healing, reduced pain and improved functional outcome vs. placebo over 3 months in pelvic fracture patients. Methods: This randomized-placebo-controlled study enrolled 35 patients (women and men ≥50 years old) within 4 weeks of pelvic fracture and evaluated the effect of blinded TPTD versus placebo over 3 months on fracture healing. Fracture healing from CT images at 0 and 3 months was assessed as cortical bridging using a 5-point scale. The numeric rating scale (NRS) for pain was administered monthly. Physical performance was assessed monthly by Continuous Summary Physical Performance Score (based on 4m walk speed, timed repeated chair stands, and balance) and the Timed Up and Go (TUG) test. Results: The mean age was 82 and >80% were female. The intention to treat analysis showed no group difference in cortical bridging score and 50% of fractures in TPTD-treated and 53% of fractures in placebo-treated patients were healed at 3 months, unchanged after adjustment for age, sacral fracture, and fracture displacement. Median pain score dropped significantly in both groups with no group differences. Both CSPPS and TUG improved in the teriparatide group, whereas there was no improvement in the placebo group (group difference p<0.03 for CSPPS at 2 and 3 months). Conclusion: In this small randomized, blinded study, there was no improvement in radiographic healing (CT at 3 months) or pain with TPTD vs placebo, however, there was improved physical performance in TPTD-treated subjects that was not evident in the placebo group

Children's Folklore

A collection of original essays by scholars from a variety of field

Osteotropic Cancers: From Primary Tumor to Bone

Tumour-induced bone disease is a common clinical feature of hematological and metastatic solid cancer. Thus, numerous scientists have gained a better understanding of the mechanisms by which certain tumor types tend to invade specifically the bone. Firstly, Stephen Paget recognized the ‘seed and soil’ hypothesis, stating that cancer cells (the ‘seeds’) can only develop in secondary organs where the microenvironment (the ‘soil’- the bone) is permissive for their growth. Today, this theory has been enlarged to the metastatic process in general, because in order to grow in distant organs, tumor cells need special properties that suit them to those organs. Specifically, in order to metastasize to bone, cancer cells firstly detach from their tissue of origin, subsequently transit through circulation, reside in the bone marrow and acquire a bone cell-like phenotype responsible for bone establishment and invasion. Each step in the metastatic cascade is rich in biological targets and mechanistic pathways, which are summarized in this review

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts. We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. Combined analysis identified 8 additional associated loci. The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56). We also confirmed previously reported associations with GJD2 and RASGRF1. Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load. Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia

Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (Nature Genetics (2013) 45 (314-318))

Link_to_subscribed_fulltex