Genetically selected alcohol preferring rats to model human alcoholism.

Animal models have been successfully developed to mimic and study alcoholism. These models have the unique feature of allowing the researcher to control for the genetic characteristics of the animal, alcohol exposure and environment. Moreover, these animal models allow pharmacological, neurochemical and behavioral manipulations otherwise impossible. Unquestionably, one of the major contributions to the understanding of the neurobiological basis of alcoholism comes from data that have been obtained from the study of genetically selected alcohol preferring rat lines and from the consequences that alcohol drinking and environmental manipulations, (i.e., protracted alcohol drinking, intoxication, exposure to stress, etc.) have on them. In fact, if on the one hand genetic factors may account for about 50-60% of the risk of developing alcohol dependence, on the other hand protracted alcohol exposure is a necessary precondition to actually develop the disease, while environmental vulnerability factors may be crucial for disease progression. The present article will offer an overview of the different genetically selected alcohol preferring rat lines developed and used to study alcoholism. The predictive, face and construct validity of these animal models and the translational significance of findings achieved through their use will be critically discussed

Disentangling flow and signals of Chiral Magnetic Effect in U plus U, Au plus Au and p plus Au collisions

We present STAR measurements of the charge-dependent three-particle correlator gamma(a,b) = /v(2){2} and elliptic flow v(2){2} in U+U, Au+Au and p+Au collisions at RHIC. The difference Delta gamma = gamma(opposite sign)-gamma(same sign) measures charge separation across the reaction plane, a predicted signal of the Chiral Magnetic Effect (CME). Although charge separation has been observed, it has been argued that the measured separation can also be explained by elliptic flow related backgrounds. In order to separate the two effects we perform measurements of the gamma-correlator where background expectations differ from magnetic field driven effects. A differential measurement of gamma with the relative pseudorapidity (Delta eta)) between the first and second particles indicate that Delta gamma in peripheral A+A and p+A collisions are dominated by short-range correlations in A. However, a relatively wider component of the correlation in Delta eta tends to vanish the same way as projected magnetic field as predicted by MC-Glauber simulations

Measurement of elliptic flow of light nuclei at sNN\sqrt{s_{NN}} = 200, 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV at RHIC

We present measurements of 2$^{nd}$ order azimuthal anisotropy ($v_{2}$) at mid-rapidity $(|y|<1.0)$ for light nuclei d, t, $^{3}$He (for $\sqrt{s_{NN}}$ = 200, 62.4, 39, 27, 19.6, 11.5, and 7.7 GeV) and anti-nuclei $\bar{\rm d}$ ($\sqrt{s_{NN}}$ = 200, 62.4, 39, 27, and 19.6 GeV) and $^{3}\bar{\rm He}$ ($\sqrt{s_{NN}}$ = 200 GeV) in the STAR (Solenoidal Tracker at RHIC) experiment. The $v_{2}$ for these light nuclei produced in heavy-ion collisions is compared with those for p and $\bar{\rm p}$. We observe mass ordering in nuclei $v_{2}(p_{T})$ at low transverse momenta ($p_{T}<2.0$ GeV/$c$). We also find a centrality dependence of $v_{2}$ for d and $\bar{\rm d}$. The magnitude of $v_{2}$ for t and $^{3}$He agree within statistical errors. Light-nuclei $v_{2}$ are compared with predictions from a blast wave model. Atomic mass number ($A$) scaling of light-nuclei $v_{2}(p_{T})$ seems to hold for $p_{T}/A < 1.5$ GeV/$c$. Results on light-nuclei $v_{2}$ from a transport-plus-coalescence model are consistent with the experimental measurements

Observation of Global Hyperon Polarization in Ultrarelativistic Heavy-Ion Collisions

Collisions between heavy nuclei at ultra-relativistic energies form a color-deconfined state of matter known as the quark-gluon plasma. This state is well described by hydrodynamics, and non-central collisions are expected to produce a fluid characterized by strong vorticity in the presence of strong external magnetic fields. The STAR Collaboration at Brookhaven National Laboratory's Relativistic Heavy Ion Collider (RHIC) has measured collisions between gold nuclei at center of mass energies root S-NN = 7.7 200 GeV. We report the first observation of globally polarized A and A hyperons, aligned with the angular momentum of the colliding system. These measurements provide important information on partonic spin-orbit coupling, the vorticity of the quark-gluon plasma, and the magnetic field generated in the collision