Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: Prevalence and metabolic consequences

Lipoatrophy and metabolic complications of treatment of human immunodeficiency virus (HIV) infection may share common associations with adipose tissue pathology and inflammation. To investigate these relationships, we undertook a large-scale study of adipose tissue, body composition, and metabolic outcomes among HIV-infected adult men at a tertiary hospital HIV cohort during the period 2001-2007. Methods. Assessments included adipose biopsies (np211) for investigation of adipocyte mitochondrial DNA content, adipocytokine expression, and adipose macrophage content; and whole-body dual-energy X-ray absorptiometry (DEXA) scans (np225) for objective body composition changes; 138 individuals contributed both biopsy and DEXA data. Results. Compared with 78 treatment-naive control subjects, 98 zidovudine recipients (48%) and 49 stavudine recipients (67%) had leg fat measures <10% threshold value. Adipose samples associated with current stavudine or zidovudine (np99) revealed significant adipocyte mitochondrial DNA depletion, adipose tissue macrophage infiltration, and elevated proinflammatory cytokine levels, compared with samples from control subjects and nonthymidine nucleoside reverse-transcriptase inhibitor (NRTI) recipients (all P<.05). Improvements in adipose pathology after NRTI switching (np21 longitudinal samples) correlated with increased preswitch adipose inflammation and less severe fat loss (both P<.05). Elevated ratios of total to high-density lipoprotein cholesterol levels and Homeostatic Metabolic Assessment scores correlated independently with lipoatrophy severity (P<.05) and increased body mass index (P<.05) in thymidine NRTI-experienced individuals. No effect of demographic or HIV-related variables, or HIV protease inhibitor therapy exposure was detected. Conclusions. Adipose tissue pathology and lipoatrophic fat loss are highly prevalent among recipients of stavudine- or zidovudine-based HIV treatment and are associated with adverse metabolic outcomes. Restoring adipose tissue health appears to be an important issue in the long-term treatment of this patient population

Intersectionality, Resistance, and History-Making: A Conversation Between Carolyn D'Cruz, Ruth DeSouza, Samia Khatun, and Crystal McKinnon, Facilitated by Jordana Silverstein

A good, solid, history-writing practice is one which, I think, shakes people's ideas of the world and their place in it, compelling them to imagine new social, cultural and political formations which can provide an account of life. Kimberle Crenshaw's development of the term 'intersectionality', and the ways it has been taken up by people of colour within the academy internationally, as well as by activists, provides one example of such imaginative work. Because when you spend some time in the Australian History academic scene, at conferences, in departments, talking to other academics, it's quickly noticeable that one of its key features is its hegemonic whiteness. Even in those spaces that aspire to avoid whiteness, it's inescapable, visible daily, as well as in the themes at conferences, the keynote speakers chosen, the food served, the knowledge shared. When it came time for the Australian Women's History Network conference in 2016, which carried the theme of 'Intersections in History', it felt like this could provide a way of modelling a different kind of Australian academic History space. What would a conversation look like that skipped over the presence of white Anglo Australians, I wondered? What if we just left them to the side? What if we gathered together some of the smartest, sharpest thinkers in Melbourne academia, and spoke amongst ourselves, coming up with new formations of knowledge? And so we did: Crystal, Samia, Ruth and Carolyn gathered together, I asked them some questions, and we had a conversation that, in numerous ways, challenged white hegemonies. We've recreated some of that conversation below, as a way of continuing to think together, and to find new ways of making this thinking public

Duty Versus Proximate Cause in the Law of Negligence - A Comparative Study

Duty Versus Proximate Cause in the Law of Negligence - A Comparative Stud

Flight and tunnel test results of the MDC mechanical jet noise suppressor nozzle

The flight and wind tunnel tests to determine the acoustic and performance effects of a mechanical jet noise suppressor nozzle mounted on a Viper engine of an HS-125 airplane are discussed. Flyover noise measurements were made with microphones mounted on top of a 137.5 m bridge tower. Seven nozzle configurations including two references nozzles, two suppressors, and three ejector inlets were tested. The suppressor nozzle of interest for an advanced supersonic transport, the suppressor/treated ejector, achieved a measured noise reduction of 14 EPNdB relative to a conventional conical reference nozzle at the highest pressure ratio tested (approximately 2.5). The unique engine nacelle, flight hardware, and nacelles from the HS-125 flight test program, combined with a simulated HS-125 fuselage were windtunnel tested. Both propulsion and acoustic data were recorded. Preliminary thrust data results from the wind tunnel tests are summarized and compared to other mechanical suppressor test results. The test results indicate that a noise reduction of at least 16 EPNdB would be possible for the suppressor/ejector nozzle scaled to typical AST engine size with a 5% thrust loss at a typical takeoff climb speed

Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study

Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701–negative recipients

On the Excess Dispersion in the Polarization Position Angle of Pulsar Radio Emission

The polarization position angles (PA) of pulsar radio emission occupy a distribution that can be much wider than what is expected from the average linear polarization and the off-pulse instrumental noise. Contrary to our limited understanding of the emission mechanism, the excess dispersion in PA implies that pulsar PAs vary in a random fashion. An eigenvalue analysis of the measured Stokes parameters is developed to determine the origin of the excess PA dispersion. The analysis is applied to sensitive, well-calibrated polarization observations of PSR B1929+10 and PSR B2020+28. The analysis clarifies the origin of polarization fluctuations in the emission and reveals that the excess PA dispersion is caused by the isotropic inflation of the data point cluster formed by the measured Stokes parameters. The inflation of the cluster is not consistent with random fluctuations in PA, as might be expected from random changes in the orientation of the magnetic field lines in the emission region or from stochastic Faraday rotation in either the pulsar magnetosphere or the interstellar medium. The inflation of the cluster, and thus the excess PA dispersion, is attributed to randomly polarized radiation in the received pulsar signal. The analysis also indicates that orthogonal polarization modes (OPM) occur where the radio emission is heavily modulated. In fact, OPM may only occur where the modulation index exceeds a critical value of about 0.3.Comment: Accepted for publication in Ap

Association between low 25(OH) vitamin D levels, antiretroviral therapy and metabolic profile in a cohort of treated ahd therapy naive HIV positive patients in Western Australia

See Attache

Eucalyptus cordata Subsp. quadrangulosa (Myrtaceae), a new taxon of restricted distribution from southern Tasmania

Eucalyptus cordata subsp. quadrangulosa is described to accommodate western populations of the species, and differs from the typical subspecies most conspicuously in the quadrangular branchlets, and also in the larger and more pointed juvenile leaves, the more flattened peduncles, the larger bi-ribbed flower buds, and the larger fruits. The quadrangular branchlets of the new subspecies are unique in E. ser. Orbiculares. The new subspecies occurs to the west of, and largely disjunct from, eastern E. cordata, and tends to occupy cooler and wetter sites. Some morphologically and geographically intermediate populations are known. Both subspecies of E. cordata are of restricted distribution and are known from relatively few, disjunct and generally numerically small populations, and as such are under threat from various natural and human-induced influences. The newly described subsp. quadrangulosa is commonly cultivated in cool climates as an ornamental tree for its silvery foliage. A key to E. ser. Orbiculares, and a distribution map and photographs of representative types of E. cordata are presented