A Case of Saethre-Chotzen Syndrome

Saethre-Chotzen syndrome was described independently by the Norwegian psychiatrist, Saethre, and the German psychiatrist, Chotzen, in the 1930s; since that time many cases have been reported, some using the terms acrocephalosyndactyly, type III, and craniooculodental syndrome. Clinically, the syndrome is characterized by premature closure of the cranial sutures, low-set hairline, nasal septum deviation, brachydactyly, and ptosis. It is inherited as an autosomal dominant with complete penetrance and great variability in expression. Because of this variable in expressivity, the syndrome is difficult to diagnose in the less severe form without a positive family history

Experimental control of natural perturbations in channel flow

International audienceA combined approach using system identification and feed-forward control design has been applied to experimental laminar channel flow in an effort to reduce the naturally occurring disturbance level. A simple blowing/suction strategy was capable of reducing the standard deviation of the measured sensor signal by 45 %, which markedly exceeds previously obtained results under comparable conditions. A comparable reduction could be verified over a significant streamwise extent, implying an improvement over previous, more localized disturbance control. The technique is effective, flexible, and robust, and the obtained results encourage further explorations of experimental control of convection-dominated flows

Objective `Safe' Grazing Capacities for South-West Queensland Australia: Development of a Model for Individual Properties

Few tools are available to assist graziers, land administrators and financiers in making objective grazing capacity decisions on Australian rangelands, despite existing knowledge regarding stocking rate theory and the impact of stocking rates on land condition. To address this issue a model for objectively estimating 'safe' grazing capacities on individual grazing properties in south-west Queensland was developed. The method is based on 'safe' levels of utilisation (15%-20%) by domestic livestock of average annual forage grown for each land system on a property. Average annual forage grown (kglha) was calculated as the product of the rainfall use efficiency (kglhdmm) and average annual rainfall (mm) for a land system. This estimate included the impact of tree and shrub cover on forage production. The 'safe' levels of forage utilisation for south- west Queensland pastures were derived from the combined experience of (1) re-analysis of the results of grazing trials, (2) reaching a consensus on local knowledge and (3) examination of existing grazing practice on 'benchmark' grazing properties. We recognise the problems in defining, determining and using grazing capacity values, but consider that the model offers decision makers a tool that can be used to assess the grazing capacity of individual properties

Experimental control of natural perturbations in channel flow

A combined approach using system identification and feed-forward control design has been applied to experimental laminar channel flow in an effort to reduce the naturally occurring disturbance level. A simple blowing/suction strategy was capable of reducing the standard deviation of the measured sensor signal by 45 %, which markedly exceeds previously obtained results under comparable conditions. A comparable reduction could be verified over a significant streamwise extent, implying an improvement over previous, more localized disturbance control. The technique is effective, flexible, and robust, and the obtained results encourage further explorations of experimental control of convection-dominated flows

Differential effects of repeated inspiratory and limb muscle loading on effort perception in patients with obstructive sleep apnea and healthy males

Abstract Obstructive sleep apnea (OSA) is characterized by collapse of the upper airways during sleep. The contribution of alterations in effort perception is not understood. This study investigated the response of inspiratory and quadriceps muscles to repetitive loading on effort perception in OSA patients, pre and post continuous positive airway pressure (CPAP) treatment, and in healthy individuals. Twenty‐one OSA patients and 40 healthy participants completed protocols for repetitive inspiratory and leg muscle loading combined with intermittent rating of perceived exertion (RPE 14—somewhat hard/hard) to assess effort sensitivity. Electromyography, inspiratory pressure and isometric force were measured. OSA patients reported higher fatiguability of respiratory and leg muscles than controls. OSA patients revealed lower effort sensitivity in the leg muscles compared with controls, while repetitive loading led to a decline in force production. In the respiratory system, OSA patients revealed similar effort sensitivity at baseline compared with controls, but a large reduction in effort sensitivity after loading. Baseline effort sensitivity was correlated with apnea‐hypopnea index (AHI). After CPAP treatment, OSA patients revealed a decreased baseline effort sensitivity with a missing loading response. Effort sensitivity was differentially affected in the respiratory and leg systems with outcomes of CPAP treatment suggesting a full reversibility. Outcomes suggest that reversible adaptive response of effort perception in the respiratory system might contribute to the severity of OSA

Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region

Between January 2005 and December 2005, 199 meticillin-resistant Staphylococcus aureus (MRSA) isolates were obtained from nonhospitalised patients presenting skin and soft tissue infections to local general practitioners. The study area incorporated 57 surgeries from three Primary Care Trusts in the Lichfield, Tamworth, Burntwood, North and East Birmingham regions of Central England, UK. Following antibiotic susceptibility testing, pulsed-field gel electrophoresis, Panton-Valentine leukocidin gene detection and SCCmec element assignment, 95% of the isolates were shown to be related to hospital epidemic strains EMRSA-15 and EMRSA-16. In total 87% of the isolate population harboured SCCmec IV, 9% had SCCmec II and 4% were identified as carrying novel SCCmec IIIa-mecI. When mapped to patient home postcode, a diverse distribution of isolates harbouring SCCmec II and SCCmec IV was observed; however, the majority of isolates harbouring SCCmec IIIa-mecI were from patients residing in the north-west of the study region, highlighting a possible localised clonal group. Transmission of MRSA from the hospital setting into the surrounding community population, as demonstrated by this study, warrants the need for targeted patient screening and decolonisation in both the clinical and community environments

Climate Change in Queensland's Grazing Lands: II. An Assessment of the Impact on Animal Production From Native Pastures

The 160 million ha of grazing land in Queensland support approximately 10 million beef equivalents (9.8 million cattle and 10.7 million sheep) with treed and cleared native pastures as the major forage source. The complexity of these biophysical systems and their interaction with pasture and stock management, economic and social forces limits our ability to easily calculate the impact of climate change scenarios. We report the application of a systems approach in simulating the flow of plant dry matter and utilisation of forage by animals. Our review of available models highlighted the lack of suitable mechanistic models and the potential role of simple empirical relationships of utilisation and animal production derived from climatic and soil indices. Plausible climate change scenarios were evaluated by using a factorial of rainfall (f 10%) * 3260C temperature increase * doubling CO, in sensitivity studies at property, regional and State scales. Simulation of beef cattle liveweight gain at three locations in the Queensland black speargrass zone showed that a *lo% change in rainfall was magnified to be a f 15% change in animal production (liveweight gain per ha) depending on location, temperature and CO, change. Models of 'safe' carrying capacity were developed from property data and expert opinion. Climate change impacts on 'safe' carrying capacity varied considerably across the State depending on whether moisture, temperature or nutrients were the limiting factors. Without the effect of doubling CO,, warmer temperatures and +lo% changes in rainfall resulted in -35 to +70% changes in 'safe' carrying capacity depending on location. With the effect of doubling CO, included, the changes in 'safe' carrying capacity ranged from -12 to +115% across scenarios and locations. When aggregated to a whole-of-State carrying capacity, the combined effects of warmer temperature, doubling CO, and +lo% changes in rainfall resulted in 'safe' carrying capacity changes of +3 to +45% depending on rainfall scenario and location. A major finding of the sensitivity study was the potential importance of doubling CO, in mitigating or amplifying the effects of warmer temperatures and changes in rainfall. Field studies on the impact of CO, are therefore a high research priority. Keywords: climate change, Queensland, simulation, rangelands, beef production, cattle, carrying capacity, CO,, utilisatio